innate immune response – Page 20 – Communicable Diseases Research

Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly

노인의 잠재적 인 Covid-19 치료제로서 Boswellic acids/Boswellia serrata 추출물

Review

Published on 2021-08-012022-08-31
Journal: Inflammopharmacology [Category] MERS, 유전자 메커니즘, 치료제,

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

인간에서 BNT162b2 mRNA 백신의 시스템 백신학

Observational Study

Published on 2021-08-012022-09-11
Journal: Nature [Category] Fulltext, MERS, 변종, 비임상, 유전자 메커니즘, 임상, 진단,

[키워드] Adaptive immune response Analysis Antigen AP-1 approach B.1.351 B.1.351 variant BNT162b2 BNT162b2 mRNA vaccine booster booster vaccination CD14 CD16 CD4 CD8 T cell CD8 T cells Cluster Concentration demonstrated elicit Emergency use authorization evidenced Frequency greater healthy volunteer Human immune response immune responses immune system immunization increase in Inflammatory inflammatory monocytes innate antiviral immunity innate immune response innate immune system interferon landmark less monocyte Monocytes mRNA vaccination mRNA vaccine mRNA vaccines myeloid cell Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses pathway Pfizer-BioNTech mRNA vaccine plasma protective immune response reduced robust SARS-CoV-2 second dose secondary immunization significant increases in single-cell stimulate stimulated System T cell T cells These data transcription factor transcription factors transcriptional transcriptomics vaccination wild-type SARS-CoV-2
[DOI] 10.1038/s41586-021-03791-x PMC 바로가기 [Article Type] Observational Study

Vitamin D, infections and immunity

비타민 D, 감염 및 면역

Review

Published on 2021-07-292022-09-10
Journal: Reviews in Endocrine & Metabolic Disorders [Category] 유전자 메커니즘,

[키워드] β-defensin 2 25-hydroxyvitamin D accelerate Analysis Antibacterial antimicrobial peptide antimicrobial peptides Antiviral antiviral responses arising autophagy benefit best CAMP caries cascades Cathelicidin characterized condition COVID-19 COVID-19 crisis COVID-19 pandemic Critical CYP27B1 deficiency Dental caries disease severity Diseases downstream dysregulation epidemiological Evidence expression expression of gene greater handling Health identify Immune cell immune cells immune responses Immunity in some induce Infection Infectious diseases Inflammation Inflammatory bowel disease inflammatory bowel diseases innate immune innate immune response innate immune responses innate immune system intestinal flora intracellular pathogens knowledge Laboratory Local macrophages mechanism microbial Mortality NOD2 pathogen Pathogens Pattern recognition Pattern recognition receptors peptide peptides Poor promote provide reduce respiratory respiratory tract severity Signaling signaling cascade signaling cascades skeletal stimulate Strong susceptibility therapeutic intervention therapeutic interventions therapeutic potential Tuberculosis turn upstream Vaccines Viral viral infections Vitamin D vitamin D deficiency Vitamin D status Vitamin D supplementation
[DOI] 10.1007/s11154-021-09679-5 PMC 바로가기 [Article Type] Review

FIP200 restricts RNA virus infection by facilitating RIG-I activation

Article

Published on 2021-07-292022-10-31
Journal: Communications Biology [Category] Coronavirus,

Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19

중증 COVID-19 모델에서 SARS-CoV-2 감염에 대한 반응의 동역학적 다중 오믹 분석

Pathogenesis and Immunity

Published on 2021-07-282022-09-10
Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] absence active viral infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar animal model animal models approach caused changes in chemokines coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 develop disease effort evaluated Extrapulmonary gene transcription hamster heart host response host responses human disease human isolates of SARS-CoV-2 immune in vivo increase in Infection innate immune response interferon interferon-stimulated gene isolate kidney kidneys kinetic kinetic analysis lack Model Monocytes Multiorgan neutrophil pandemic Pathogenesis pathology peaked phosphoproteome Phosphoproteomics Pneumonia protein expression proteome proteomics pulmonary disease respiratory response RNA-Seq SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 severe SARS severe SARS-CoV-2 These data to define Transcription Transcriptome transcriptome changes type I Viral viral infection
[DOI] 10.1128/JVI.01010-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity

Sex Disparities in Efficacy in COVID-19 Vaccines: A Systematic Review and Meta-Analysis

Article

Published on 2021-07-272022-10-28
Journal: Vaccines [Category] COVID-19,

Perspective of the Relationship between the Susceptibility to Initial SARS-CoV-2 Infectivity and Optimal Nasal Conditioning of Inhaled Air

Review

Published on 2021-07-242022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome Affect age available data Conditioning coronavirus coronavirus disease country COVID-19 eliminating epithelial cell epithelial cells Evidence face Gender genetic background genetic factors in SARS-CoV-2 susceptibility Infectivity Influenza virus Inhaled initial innate immune response Innate immunity interferon male Mask nasal nasal conditioning of inspired air nasal epithelium nasopharynx Older promote recent reducing relationship respiratory viral infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 infectivity SARS-CoV-2 transmission severe COVID-19 shown Spread temperature tropical upper respiratory tract upper respiratory tract immunity URT viral infection Viral load virus transmission vulnerable person zone
[DOI] 10.3390/ijms22157919 PMC 바로가기 [Article Type] Review

The Anti-Viral Applications of Marine Resources for COVID-19 Treatment: An Overview

COVID-19 치료를 위한 해양 자원의 항바이러스 응용: 개요

Review

Published on 2021-07-232022-09-10
Journal: Marine Drugs [Category] SARS, 치료제,

[키워드] ACE-2 Algae anionic anti-inflammatory agent Anti-viral anti-viral effect Antiviral application Bacteria bromotyrosines Compound compounds conducted COVID-19 COVID-19 therapy Dexamethasone downregulate drug Drug discovery Efficacy focus Google Scholar highlight induce infected patients inhibit innate immune response inorganic lack leads life cycle M pro marine algae marine protein marine sponge market mechanism metabolite molecular weight organism pandemic phycocyanobilins polyp polysaccharide Prevent protease Protein protein synthesis Remdesivir Replication required resource SARS-CoV-2 SARS-CoV-2 infected patients shown sulfated polysaccharides therapy Treatment Viral viral entry viral life cycle
[DOI] 10.3390/md19080409 PMC 바로가기 [Article Type] Review

SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity

SARS-COV-2 N 단백질은 타고난 면역을 억제하기 위해 TRIM25- 매개 RIG-I 활성화를 표적으로합니다.

Article

Published on 2021-07-232022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료법,

[키워드] accessory proteins Activation Affect affecting antagonistic characterized clinical picture contributing to counteract COVID-19 Cytokines decrease demonstrated domain ENCODE exacerbated expressed feature host immune system IFN Infection Innate innate immune response Innate immunity Interaction involved Mask mechanism molecular mechanism molecular mechanisms N protein novel SARS-CoV-2 virus occurred Pathways Pattern recognition pattern recognition receptor pro-inflammatory cytokine pro-inflammatory cytokines Protein PRR Recognition reported RIG-I RIG-I activation SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 virus secretion signaling pathways suppresse target the N protein the SARS-CoV-2 TRIM25 Viral viral pathogenesis
[DOI] 10.3390/v13081439 PMC 바로가기 [Article Type] Article

Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks

Original Research

Published on 2021-07-222023-06-03
Journal: Frontiers in Immunology [Category] B형 간염, Fulltext,

[키워드] Acute hepatitis B Chronic Hepatitis B Hepatitis B virus innate immune response Pattern recognition receptors Woodchuck
[DOI] 10.3389/fimmu.2021.713420 PMC 바로가기 [Article Type] Original Research