interferon – Page 20 – Communicable Diseases Research

A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19

시스템 생물학 접근 방식으로 COVID-19 중증 환자의 사망률을 줄이기 위한 후보 약물 식별

Article

Published on 2022-06-032022-09-11
Journal: Science Advances [Category] COVID19(2023년), SARS, 치료제,

Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types

질병 관련 면역 세포 유형에서 프로모터 중심 Capture-C를 사용하여 COVID-19 GWAS 유전자좌에서 이펙터 유전자 관련

Article

Published on 2022-06-032022-09-11
Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종,

[키워드] Adaptive immune response approach attenuate B cell broad spectrum chromatin condition COVID COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical illness death differentially expressed disease disease severity disease-associated e genes element exacerbate functional GART Genes genetic component Genome-wide association study genomic GWAS High-resolution Hospitalization human genetic variation IFNAR2 Immune cell immune cell type immune cells implicated in viral Inflammation interferon interferon response involved life-threatening limit loci magnitude Mild Moderate COVID-19 no symptom OAS1 OAS3 offer Patient PAXBP1 Replication risk SARS-CoV-2 SARS-COV-2 infection target the interferon Therapeutics TNFAIP8L1 variant viral replication
[DOI] 10.1186/s13059-022-02691-1 PMC 바로가기 [Article Type] Article

Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19

인터페론 경로 루푸스 위험 대립 유전자는 급성 COVID-19로 인한 사망 위험을 조절합니다

Article

Published on 2022-06-012022-09-11
Journal: Translational research : the journal of laboratory [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제,

[키워드] Activation activator acute COVID-19 age allele alleles analyzed antiviral immunity Biomarker Blood BMI = body mass index body mass body mass index C-reactive protein cGMP contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 = coronavirus disease 2019 Critical CRP = C-reactive protein D-dimer death Defense disease domain Effect gain-of-function Genetic genetic information genetic risk factor Genotype groups Haplotype Helicase high risk idea IFIH1 IFIH1 = interferon-induced with helicase c domain 1 IFN IFN = interferon IFN pathway Increased interferon interferon regulatory factor IRF = interferon regulatory factor IRF5 IRF7 IRF8 lupus erythematosus modulate Mortality nucleotide NYU = New York University older subjects OR = odds ratio pathway Patient positive Predictive Primary outcome PRKG1 PRKG1 = protein kinase cGMP-dependent 1 protective effect Protective effects Protein protein kinase Regulatory risk risk allele risk factor risk of death significantly Single nucleotide polymorphism SLE SLE = systemic lupus erythematosus SNP = single nucleotide polymorphism STAT4 STAT4 = signal transducer and activator of transcription 4. subjects Support systemic lupus erythematosus Transcription troponin Type Type I IFN type I interferon variants viral infections York younger patient younger patients
[DOI] 10.1016/j.trsl.2022.01.007 PMC 바로가기 [Article Type] Article

Inflammasome activation in infected macrophages drives COVID-19 pathology

감염된 대식세포의 인플라마좀 활성화는 COVID-19 병리를 유발합니다

Article

Published on 2022-06-012022-09-12
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] ACE2 receptors activate Activation antibody attenuate blockade blocking cascade CD16 characterized contributing to COVID-19 COVID-19 pathology Critical disease downstream host infection Human immune system human macrophage humanized hyperinflammatory state IFN IL-1 IL-18 immune in vivo Infection Infectious virus Inflammasome inflammasome activation inflammasomes Inflammatory cytokine inflammatory cytokine production inflammatory macrophages Inflammatory response interferon Lung inflammation Lung pathology Lungs Macrophage macrophages NLRP3 inflammasome overactive pathology pathway Prevent pyroptosis Remdesivir Replication required SARS-CoV-2 SARS-COV-2 infection Stage sustained undergo viral replication Viral RNA
[DOI] 10.1038/s41586-022-04802-1 PMC 바로가기 [Article Type] Article

A humanized mouse model of chronic COVID-19

만성 COVID-19의 인간화 마우스 모델

Article

Published on 2022-06-012022-09-11
Journal: Nature biotechnology [Category] Fulltext, MERS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome adaptive adeno-associated virus antibody coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease early infection feature fibrosis human ACE2 human immune response humanized immune response immune responses immunological immunopathology Infection Infectious disease Inflammatory inflammatory macrophage inflammatory macrophages Injury interferon interferon-stimulated gene lung Lung pathology Lungs lymphopenia Macrophage macrophages mechanism mice Patient respiratory Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease steroid Steroids sustained T cell T cell lymphopenia Viral Viral RNA weight loss
[DOI] 10.1038/s41587-021-01155-4 PMC 바로가기 [Article Type] Article

Clinical and genomic data of sars-cov-2 detected in maternal-fetal interface during the first wave of infection in Brazil

브라질의 첫 번째 감염 파동 동안 산모-태아 경계면에서 검출된 sars-cov-2의 임상 및 게놈 데이터

Article

Published on 2022-06-012022-09-11
Journal: Microbes and infection [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] abortion Americas Apoptosis B.1.1.28 B.1.1.33 Brazil circulating clinical Clinical virology contribute coronavirus fetal Fetal placenta First wave FIVE genomes genomic data gestation Ground-glass opacities ground-glass opacity highest hospital hospital discharge IgM Illumina Miseq in viral indicate induction of apoptosis Infection interferon involved Lineage Lungs Maternal Mild molecular virology mother Mutation Neonatal infection Newborn nonsynonymous mutation Nonsynonymous mutations Nsp12 Nsp3 ORF3 ORF7b outcome Pathways Phylogeny Placenta pregnant women Preterm birth preterm births Protein qPCR Replication reported RT-qPCR SARS-CoV-2 SARS-COV-2 infection secretion Sequencing South spontaneous abortion state stillborn symptomatic symptomatic cases tested treated umbilical Umbilical cord vertical transmission viral replication Virological virus women
[DOI] 10.1016/j.micinf.2022.104949 PMC 바로가기 [Article Type] Article

Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction

감산 단백질체학 보조 치료 표적 마이닝 및 면역 반응 유도를 위한 Candida auris에 대한 앙상블 백신 설계

Article

Published on 2022-06-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] antigenic approach B cell Candida Candida auris candidate caused characterization Co-infection COVID-19 COVID-19 patient CTL demonstrated effective effective therapy Efficacy feature global pandemic HTL IgG IgM IL-6 immune immune response Immune simulation immunogenic peptide in-silico Infection infections interferon Interferon-α molecular docking Multi-epitope vaccine non-allergenic peptides producing proteome proteomics provide SARS-CoV-2 Seven Subtractive proteomics target targets the vaccine therapeutic target therapeutic targets threshold Vaccine vaccine candidate vaccine candidates Vaccines validation variant variants was performed
[DOI] 10.1016/j.compbiomed.2022.105462 PMC 바로가기 [Article Type] Article

Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis

중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석

Clinical Trial

Published on 2022-06-012022-09-11
Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제,

[키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19
[DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial

Long term persistence of SARS-CoV-2 humoral response in multiple sclerosis subjects

다발성 경화증 환자에서 SARS-CoV-2 체액 반응의 장기간 지속

Article

Published on 2022-06-012022-09-11
Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age anti-Spike IgG anti-spike IgG levels appearance benefit BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2-mRNA vaccine booster booster vaccination booster vaccinations Cladribine Cohort comparable coronavirus Coronavirus-19 dimethyl fumarate Disease modifying therapies dose eight evaluated faster fingolimod Fingolimod- Glatiramer Glatiramer acetate groups healthy control healthy controls humoral humoral immune response Humoral persistence Humoral response IgG IgG levels interferon long term mRNA vaccine Multiple multiple sclerosis Natalizumab Ocrelizumab pandemic Patient patients persistence receiving regimen respiratory SARS-CoV-2 SARS-CoV-2 BNT162b2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike Spike protein subject subjects Teriflunomide the SARS-CoV-2 titre variants
[DOI] 10.1016/j.msard.2022.103800 PMC 바로가기 [Article Type] Article

Cytokine response over the course of COVID-19 infection in pregnant women

임산부의 코로나19 감염 과정에서 사이토카인 반응

Article

Published on 2022-06-012022-09-12
Journal: Cytokine [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] Affect Clinical severity cohorts conducted controls coronavirus disease correlated Course COVID-19 COVID-19 infection COVID-19 symptom cytokine level cytokine profile defined elevated ELISA G-CSF HGF IgG antibodies IgM and IgG IgM seroconversion IL-18 IL-8 Infection infections interferon interleukin IP-10 material NIH Patient patients positive positive RT-PCR Pregnancy pregnant pregnant women profile progression remained returned RT-PCR SARS-CoV-2 serology seronegative seropositive severe disease severity significantly specific IgM stratified tested uninfected Vital were measured
[DOI] 10.1016/j.cyto.2022.155894 PMC 바로가기 [Article Type] Article