Conformational Reorganization of the SARS Coronavirus Spike Following Receptor Binding: Implications for Membrane FusionResearch Article Published on 2007-10-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 ACE2 binding Analysis angiotensin-converting enzyme 2 Cell culture change conformational change Cryo-electron microscopy domain fusion in viral initial Isolation membrane fusion molecular morphology occur produced Protein Proteins provide purified receptor Receptor binding reorganization SARS Coronavirus SARS-CoV shown spike subsequent transmembrane domains viral spike virion [DOI] 10.1371/journal.pone.0001082 PMC 바로가기 [Article Type] Research Article
Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groupsResearch Article Published on 2006-10-042022-10-28 Journal: BMC Microbiology [Category] Coronavirus, [키워드] acute respiratory syndrome adaptive addition Amino acid changes in characterized contribute coronavirus Course CoV detected different domain Epidemic epidemiological Evolution found greater group groups heptad repeat hosts human host humans membrane fusion occurred outbreak Phylogenetic tree positive Positive selection proportion Protein RBD receptor residue Result reveal S gene S protein SARS-CoV selected selective selective pressure selective sweep spike gene strain subsequent the S protein Transmission two group two groups Variation viral adaptation [DOI] 10.1186/1471-2180-6-88 PMC 바로가기 [Article Type] Research Article
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike proteinArticle Published on 2006-04-172022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] affected Anti-viral antiviral activity Asia Atypical cell cytotoxicity Class I viral fusion protein Concentration concentrations coronavirus CoV domain dose-dependent Effect Europe fusion peptide fusion protein glycoprotein heptad repeat hydrophobicity IC50 identify inhibited inhibition inhibitor membrane membrane fusion MHV murine hepatitis virus N-terminus North America peptide Peptide inhibitor Pneumonia provide recent Receptor binding Region regions responsible S2 subunit SARS-CoV severe Severe acute respiratory syndrome-associated coronavirus six-helix bundle tested the S protein viral infectivity viral spike viral spike protein was used white [DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article
A conditional-lethal murine coronavirus mutant that fails to incorporate the spike glycoprotein into assembled virionsArticle Published on 2000-03-072022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Analysis Cell coronavirus found host cell receptor Infected membrane fusion MHV MHV-A59 mouse hepatitis virus murine mutant phenotype Point mutation receptor responsible resulting S glycoprotein S protein Serine shown spike glycoprotein syncytia formation temperature Temperature-sensitive mutant virion virus virus assembly wild type [DOI] 10.1016/0168-1702(95)00100-X PMC 바로가기 [Article Type] Article