Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumoniaResearch Article Published on 2021-08-232022-10-31 Journal: eLife [Category] COVID-19, MERS, [키워드] Analysis approach caused CD8 Cell Characteristics Cohort community-acquired pneumonia control subjects controls COVID-19 disease dysregulated eight etiology expand feature host response Human immune Influenza lack monocyte mononuclear cell natural killer cell non-infectious Pathogens Patient patients with COVID-19 PBMC performed Peripheral blood peripheral immune response phenotypic Pneumonia proteomic SARS-CoV-2 single-cell transcriptional transcriptomic type I unique [DOI] 10.7554/eLife.69661 PMC 바로가기 [Article Type] Research Article
Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19Medicine Published on 2021-08-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ACE2 expression acid acute respiratory syndrome angiotensin-converting enzyme 2 Barrett's esophagus cell stress Cohort Comorbidities Comorbidity condition coronavirus COVID-19 COVID-19 patient COVID-19 severity death drugs elevated expression Glucose higher risk host receptor Human human tissue hypoxia increase increase in independent individual infect inhibitor lung monocyte Patient pH Proton Pump Inhibitors reduced SARS-CoV-2 SARS-COV-2 infection severe COVID-19 tissue Viral load [DOI] 10.3389/fmed.2021.637885 PMC 바로가기 [Article Type] Medicine
Swab and Sputum SARS-CoV-2 RNA-Negative, CT-Positive, Symptomatic Contacts of COVID-19 Cases: A Hypothesis-Generating Prospective Population-Based Cohort Study of Eight ClustersMedicine Published on 2021-08-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Administered albumin level antibacterial therapy Asymptomatic Bronchoalveolar lavage C-reactive protein case quarantine and contact tracing Characteristics China close contact Cluster confirmed COVID-19 case confirmed COVID-19 cases Confirmed COVID-19 infection Contact Corticosteroid Course COVID-19 COVID-19 case COVID-19 cases COVID-19 patient CT finding CT findings D-dimer level described diagnosing diarrhea discharge eight enrolled eosinophil erythrocyte sedimentation rate feature group had no illness onset laboratory-confirmed less leucocyte monocyte multi-cluster study neutrophil Non-COVID-19 non-COVID-19 pneumonia cases Oxygen therapy Patient patients pneumonia case population-based cohort positive positive COVID-19 Prospective prospective population-based cohort study remained respiratory specimens RNA negative CT positive symptomatic contacts rRT-PCR SARS-CoV-2 SARS-CoV-2 RNA specific antibodies specimen sputum Symptom symptomatic symptomatic contact test negative tested the disease the SARS-CoV-2 three group throat swab total protein Transmission transmitted virus RNA while [DOI] 10.3389/fmed.2021.685544 PMC 바로가기 [Article Type] Medicine
Matrix metalloproteinases are involved in the development of neurological complications in patients with Coronavirus disease 2019Article Published on 2021-08-172022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, SARS, [키워드] Adhesion Molecule caused CCL2 CCL3 CCL4 CCL7 cerebrospinal fluid chemokine chemokines Coronavirus disease 2019 COVID-19 COVID-19 patient CSF CX3CL1 CXCL8 cytokine E-selectin ENhance evaluated expression Frequency help ICAM-1 IL-1β IL-6 Increased infiltration inflammatory cell Inflammatory cytokine Inflammatory cytokines involved Level matrix matrix metalloproteinases metalloproteinase monocyte Monocytes neurological Neurological complication Neurological symptom Patient promote recruitment Result resulting secreted serum significantly increased syndrome the patient TNF-α treated VCAM-1 viral infections [DOI] 10.1016/j.intimp.2021.108076 PMC 바로가기 [Article Type] Article
Development and Validation of an Early Scoring System for Prediction of Disease Severity in COVID-19 Using Complete Blood Count ParametersBiomedical Engineering Published on 2021-08-162022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] age AUC Biomarker Biomarkers Blood CBC Cell China Cohort collected college complete blood count conducted coronavirus disease count COVID-19 COVID-19 patient COVID-19 patients death develop development disease distribution early prediction of mortality risk exhibit group help Hospital admission IMPROVE increasingly Logistic machine machine learning management Medical doctor moderate monocyte Mortality mortality risk neutrophil parameter Patient Platelet prediction predictor Probability prognostic model random reduce mortality resource Retrospective study risk risk of death Scoring scoring system selected severity Spread System the disease the patient Tongji Hospital validation validation cohort was used White blood cell Wuhan [DOI] 10.1109/ACCESS.2021.3105321 PMC 바로가기 [Article Type] Biomedical Engineering
Distribution and reference interval establishment of neutral‐to‐lymphocyte ratio (NLR), lymphocyte‐to‐monocyte ratio (LMR), and platelet‐to‐lymphocyte ratio (PLR) in Chinese healthy adultsResearch Article Published on 2021-08-132022-10-30 Journal: Journal of Clinical Laboratory Analysis [Category] Coronavirus, MERS, SARS, [키워드] age calculated Chinese coronavirus disease COVID‐19 decrease defined Diseases female Gender group healthy limit linear Lymphocyte count lymphocyte‐to‐monocyte ratio male monocyte neutrophil count neutrophil‐to‐lymphocyte ratio NLR Platelet platelet‐to‐lymphocyte ratio promote reference interval Result significant difference significantly higher significantly lower Standardization upper reference limit value were measured [DOI] 10.1002/jcla.23935 PMC 바로가기 [Article Type] Research Article
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19시리아 햄스터의 시간적 omics 분석은 중간 정도의 COVID-19에 대한 세포 효과기 반응을 풉니다.Article Published on 2021-08-112022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] Adaptive immunity alterations Analysis Anti-viral blood sample Blood samples Cell cellular cellular mechanism cellular mechanisms Cellular responses COVID-19 COVID-19 patients COVID19 Cytotoxic T cell Cytotoxic T cells dataset datasets disease severity Endothelial cell endothelial cells epithelial cell epithelial cells Evidence expression functions Genes hamster identify IgM antibodies IgM antibody immune response immune responses Infection inflammatory lung injury Innate immunity longitudinal analysis lung Lung injury Lungs Macrophage macrophages Mechanisms of disease Moderate COVID-19 monocyte Monocyte-derived macrophages Pathomechanism Pathomechanisms post infection pro-inflammatory Pro-inflammatory genes proteomics response SARS-CoV-2 SARS-COV-2 infection scRNA-seq Subtypes T cell T cells Temporal Therapeutic strategies transcriptional response Viral viral clearance viral infection [DOI] 10.1038/s41467-021-25030-7 PMC 바로가기 [Article Type] Article
Triage Modeling for Differential Diagnosis Between COVID-19 and Human Influenza A Pneumonia: Classification and Regression Tree AnalysisMedicine Published on 2021-08-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission Algorithms analyzed assigned can be used classification clinician Complete coronavirus disease COVID-19 COVID-19 patient develop diagnosed differential diagnosis eosinophil hematocrit value highest hospitals Human Influenza influenza A initial screening lack Low-Density Lipoprotein cholesterol modeling monocyte pandemic Patient patients random Randomly rapid triage tools Region Regression regression tree analysis respiratory symptoms robust selected Symptoms temperature tree Triage variable with COVID-19 [DOI] 10.3389/fmed.2021.673253 PMC 바로가기 [Article Type] Medicine
Sustained expression of inflammatory monocytes and activated T cells in COVID‐19 patients and recovered convalescent plasma donorsOriginal Article Published on 2021-08-062022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS, [키워드] activated T cell activated T cells activating acute respiratory syndrome Analysis analyzed B cell B‐cell Biliary CCR2 CD8 cellular response chemotactic convalescent plasma coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 CX3CR1 cytokine cytokine production Cytokines disease Donor endothelial expected expression flow cytometry group growth healthy individual healthy subjects IL‐6 Immune cell immune cells immune response Immunity Infection infiltration Inflammatory marker inflammatory monocyte inflammatory protein inhibitory Leptin Ligand Lung injury Macrophage main mechanism Migration Mild MIP moderate monocyte Monocyte activation Monocytes New Patient patients performed Plasma cytokine positive Protein Proteins proteomics receptor recovered patient recovered patients recruited reduction in Result Saa1 serum significant increase sustained T cells target tissue Vascular [DOI] 10.1002/iid3.476 PMC 바로가기 [Article Type] Original Article
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19Article Published on 2021-08-062023-06-20 Journal: Circulation research [Category] Fulltext, MERS, [키워드] COVID-19 homeostasis Inflammation mediators macrophages monocyte Neutrophils Omega-3 fatty acids phenotype plasma [DOI] 10.1161/CIRCRESAHA.121.319142 PMC 바로가기