motif
[용어속성] Term
The m 6 A methylome of SARS-CoV-2 in host cells
Article
[키워드] Analysis
cells
Cluster
Combined
coronavirus 2
Epidemic
exhibiting
experiment
functional
Genome
genomic RNA
health emergency
high mortality
Host
host cell
identify
increase in
indicated
Interaction
Mechanisms of disease
Methylation
miCLIP
molecular mechanism
motif
mRNAs
Mutation
Phylogenetic analysis
regulate
respiratory
RNA
RNA modification
SARS-CoV-2
SARS-COV-2 infection
Spread
strain
triggered
unique
[DOI] 10.1038/s41422-020-00465-7 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41422-020-00465-7 PMC 바로가기 [Article Type] Article
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
SARS-CoV-2 스파이크의 푸린 절단은 감염 및 세포-세포 융합을 촉진하지만 필수적이지는 않습니다
Research Article
[키워드] ACE2
ACE2 receptor
activate
activated
acute respiratory syndrome coronavirus
Amino acid
Antiviral
antiviral therapies
attachment
binding
Cell
cell-cell fusion
cells
cellular protease
cellular proteases
cleavage
cleaved
cocktail
coronavirus
COVID-19 pandemic
CRISPR
CRISPR-Cas9
Donor
drug
focus
furin
furin cleavage
furin inhibitor
furin inhibitors
furin knockout cell
furin knockout cells
furin protease
fusion
fusion peptide
host cell
host cell membrane
host cell receptor
infect
infected cell
Infection
inhibitor
inhibitors
motif
multibasic site
multinucleated cells
mutant
Mutation
peptide
pre-activation
Prevent
promote
protease
protease TMPRSS2
Protein
reduce
reduces
required
Research
respiratory
responsible
reveal
S protein
S-mediated cell-cell fusion
SARS-CoV-2
SARS-CoV-2 antiviral therapy
SARS-COV-2 infection
SARS-CoV-2 infections
SARS-CoV-2 S
SARS-CoV-2 S protein
SARS-CoV-2 virus
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
spike
Spread
syncytia formation
target cell
the S protein
the SARS-CoV-2
thought
TMPRSS2
TMPRSS2 protease
treat
triggered
triggering
unique
Viral
viral infection
Viral protein
viral spread
virus
virus entry
virus entry process
virus-host membrane fusion
[DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
S1/S2 절단 부위에 돌연변이가 있는 SARS-CoV-2 변이체는 TMPRSS2 결핍 세포에서 증식하는 동안 시험관 내에서 생성됩니다
Research Article
[키워드] alteration
antivirals
bind
Cell
cell lines
cell tropism
cleavage
cleavage site
cleaved
Coronaviruses
Critical
de novo
demonstrated
direct fusion
dominant
entry pathway
exhibited
experiments
facilitate
generate
Host
host cell
host cell receptor
host protease
in vitro
inefficient
infect
motif
mutant
mutants
Mutation
performed
plaque
plaques
polybasic
Protein
proteolytic cleavage
researcher
respiratory
S gene
S protein
S1/S2 cleavage site
SARS-CoV-2
SARS-CoV-2 entry
SARS-CoV-2 propagation
SARS-CoV-2 S gene
SARS-CoV-2 variant
SARS-CoV-2 variants
screened
Serine
Severe acute respiratory syndrome
severe acute respiratory syndrome-coronavirus-2
shown
target cells
the cell
the S protein
TMPRSS2
transmembrane serine protease
Transmissibility
type strain
undergo
Vaccine
variant
Vero Cell
Vero cells
Viral
viral entry
virus
virus strains
virus variants
viruses
wild-type strain
[DOI] 10.1371/journal.ppat.1009233 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009233 PMC 바로가기 [Article Type] Research Article
Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein
Review
[키워드] ACE2
activate
Activation
aggregation
Alternative pathway
alveolar cell
Amino acid
amplify
Angiogenesis
B.1.1.7
binding
Biological
Blood
Cell
cell entry
clinical
Coagulation
consequence
Consequences
contribute
COVID-19
developmental
domain
dysregulation
endothelial
Endothelial cell
ENhance
enzyme
Factor
Factors
high variability
Host
Hypothesis
Impact
impacts
in viral
include
independent
integrin
integrin-mediated
integrin-mediated signaling
Integrins
Interaction
microthrombi
modulated
motif
Mutation
N501Y
Numerous
pathway
Pathways
Platelet
Platelets
Pneumocytes
procoagulant
receptor
Receptor-binding domain
resulting
RGD motif
SARS CoV-2
sequence
Signaling
signaling pathway
spike
Spike protein
strain
stroke
suggested
susceptibility
the receptor-binding domain
the SARS-CoV-2 virus
the spike protein
thrombosis
thrombotic
tissue
tissue damage
tissue microenvironment
variant
viral entry
virion
virion binding
virus
widespread
[DOI] 10.3390/v13020146 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/v13020146 PMC 바로가기 [Article Type] Review
Structure of the multiple functional domains from coronavirus nonstructural protein 3
Coronaviruses
[키워드] active site
activity
Antiviral
asymmetric unit
catalytic domain
cleavage site
cleave
complex
conducted
conserved
coronavirus
CoV
CoVs
domain
drug design
enzyme activity
exhibit
fluorescent
functional
homodimer
Host
infect
Interaction
macro
Macro domain
mimicking
monomer
motif
Multiple functional domains
mutant
Neurological diseases
nonstructural protein 3
Nsp3
pandemic
Papain-like protease
papain-like protein
pathogen
peptide
PLPro
protease
protein 3
replication mechanism
significantly
stability
stimulated
Structure
substrate
substrates
subunit
targets
ubiquitin-like domain
variety
[DOI] 10.1080/22221751.2020.1865840 PMC 바로가기 [Article Type] Coronaviruses
[DOI] 10.1080/22221751.2020.1865840 PMC 바로가기 [Article Type] Coronaviruses
In silico Analysis Revealed Potential Anti-SARS-CoV-2 Main Protease Activity by the Zonulin Inhibitor Larazotide Acetate
Chemistry
[키워드] activity
acute lung injury
acute respiratory distress
airways
ameliorated
animal model
anti-SARS-CoV-2
anti-viral activity
ARDS
binding
Blood
catalytic domain
characterized
co-crystallized
Combined
component
conformational
COVID-19 infection
Drug repurposing
Efficacy
endothelial
engage
enzyme
epithelial
expand
Gas exchange
infected patient
inhibitor
Interaction
interstitial pneumonia
involved
larazotide
larazotide acetate
lifecycle
ligands
Lungs
M pro
Mpro inhibitor
MM-GBSA
molecular
molecular docking
molecular dynamics
Mortality
motif
Mouse models
mucosal
neutrophil
outcome
pandemic
Pathogenesis
Peptide inhibitor
phase 3 trial
plasma
Potential
profiles
protease
Protein
reported
Respiratory failure
responsible
resulting
Revealed
robust
steric hindrance
Structure
subject
subsequent
syndrome
the SARS-CoV-2
Treatment
turn
variety
[DOI] 10.3389/fchem.2020.628609 PMC 바로가기 [Article Type] Chemistry
[DOI] 10.3389/fchem.2020.628609 PMC 바로가기 [Article Type] Chemistry
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications
Review
[키워드] ACE2
affinity binding
Amino acid sequences
amino acids
angiotensin-converting enzyme 2
assays
autophagic
autophagy
autophagy machinery
binding
bioinformatics
candidate
cause
Cell
cell entry
complex
component
components
conserved
COVID-19
cytoplasmic tail
cytosolic
develop
Disease progression
endocytic
engage
examined
host cell
host cell surface
host-directed therapy
hypothese
identify
implication
integrin
integrin signaling
Integrins
Interaction
interactions
linear
mechanism
membrane
molecular
motif
overlap
peptide
Phosphorylation
predict
predicted
Prevent
Protein
protein domain
Proteins
PTB
receptor
recruit
regulated
Regulatory
Replication
reported
resource
SARS-CoV-2
SARS-CoV-2 entry
sequence
Signaling
subunit
surface receptor
therapeutic
tyrosine
Vertebrate
viral infection
viral spike protein
virus
[DOI] 10.1126/scisignal.abd0334 PMC 바로가기 [Article Type] Review
[DOI] 10.1126/scisignal.abd0334 PMC 바로가기 [Article Type] Review
Low ADAMTS13 Activity Correlates with Increased Mortality in COVID-19 Patients
Original Article
[키워드] Activation
activity
ADAMTS13
Admission
Antigen
association
Biomarker
Biomarkers
cause
Coagulation
Coagulopathy
conducted
coronavirus disease
COVID-19
COVID-19 patient
D-dimer
died
discharged
disease severity
distribution
Efficacy
elevated
elevated lactate dehydrogenase
endothelial
greater
Hemolysis
hospitalized COVID-19 patient
hospitalized patients
Increased
less
metalloproteinase
Mortality
motif
nonsurvivors
organ damage
Patient
Presence
Randomly
Retrospective study
schistocytes
selected
significantly
significantly increased
significantly lower
subset
survived
survivor
Treatment
von Willebrand factor
vWF
[DOI] 10.1055/s-0041-1723784 PMC 바로가기 [Article Type] Original Article
[DOI] 10.1055/s-0041-1723784 PMC 바로가기 [Article Type] Original Article
Stapled ACE2 peptidomimetics designed to target the SARS‐CoV ‐2 spike protein do not prevent virus internalization
Full Paper
[키워드] ACE2
antiviral activity
assays
binding
caused
cell entry
coronavirus
COVID‐19
enzyme
human ACE2 receptor
immunofluorescence
inhibit
Interaction
motif
neutralization
Novel coronavirus
peptide
peptidomimetic
PPI
Prevent
protein‐protein interaction
pseudovirus
RBD
RBD binding
required
SARS‐CoV‐2
SARS‐CoV‐2
Spike protein
stapled peptides
virus
were assessed
[DOI] 10.1002/pep2.24217 PMC 바로가기 [Article Type] Full Paper
[DOI] 10.1002/pep2.24217 PMC 바로가기 [Article Type] Full Paper