Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patientsResearch Article Published on 2022-02-102022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), SARS, [키워드] antibody Antibody avidity Antibody Response average BNT162b2 correlated Course Coverage COVID-19 delta variant dialysis dose fraction Hemodialysis IgG antibody immunized Intervention mRNA-1273 mRNA-1273 vaccines neutralization Neutralizing activity neutralizing antibody non-responder of BNT162b2 Patient patients Peritoneal dialysis plasma sample Poor Prophylactic reduced reduction required risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike the antibody response the patient therapeutic therapeutic strategy understanding undetectable vaccination variants [DOI] 10.1371/journal.pone.0263328 PMC 바로가기 [Article Type] Research Article
Molecular and Epidemiological Characterization of Emerging Immune-Escape Variants of SARS-CoV-2Medicine Published on 2022-02-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Analysis antibodies Beta BNT162b2 mRNA vaccine booster vaccination characterization circulating circulating variants conducted coronavirus coronavirus disease COVID-19 COVID-19 vaccine Delta displaying dual antibody cocktail therapy E484K Efficacy emerging variants epidemiological survey exhibited Gamma identify individual management monoclonal antibody mRNA vaccine N501Y mutation neutralization Neutralizing Neutralizing activity Neutralizing antibodies pandemic prevalent SARS-CoV-2 SARS-CoV-2 variant shown significantly Spike protein therapeutic vaccination Vaccine vaccinee variant variants Virus-like particle [DOI] 10.3389/fmed.2022.811004 PMC 바로가기 [Article Type] Medicine
An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variantsArticle Published on 2022-02-092022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] amino acid substitutions antibodies antibody B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 B.1.621 Beta binding epitope Clinical use convalescent patient Delta determine domain Drug development Effectiveness experiment extension fusing Gamma highlight host adaptation human IgG1 Fc identify IMPROVE Lambda Microbiology Mutation mutations nanobody neutralization breadth neutralization potency neutralize Neutralizing activity neutralizing antibody omicron P.1 RBD RBD mutations SARS-CoV-2 SARS-CoV-2 neutralization activity SARS-CoV-2 variant spike stability tested the RBD therapeutic Transmission Vaccine variant virus [DOI] 10.1038/s41392-022-00912-4 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchySARS-CoV-2 변이체는 면역 우세 계층이 이동된 항체 반응을 유발합니다Research Article Published on 2022-02-082022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta 501Y.V2 affected antibodies antibody Antibody Response B.1.351 B.1.351 variant Beta conserved delta variant determine Donor donors elicit elicited epitope Epitopes Frequency Human humans Immunity immunodominance immunodominant infected with SARS-CoV-2 Infection Influenza isolate isolates less mutant mutated Mutation neutralization Neutralizing activity polyclonal antibodies polyclonal antibody produced RBD Region residue SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera serum Specificities specificity spike epitopes spike receptor-binding domain susceptibility the antibody response the RBD vaccination variant variants Viral viral isolates viral spike virus viruses while [DOI] 10.1371/journal.ppat.1010248 PMC 바로가기 [Article Type] Research Article
Multiplexed Lab-on-a-Chip Bioassays for Testing Antibodies against SARS-CoV-2 and Its Variants in Multiple Individuals여러 개인의 SARS-CoV-2 및 그 변이체에 대한 항체 테스트를 위한 다중 랩온어칩 바이오어세이Article Published on 2022-02-082022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody bioassay Concentration coronavirus D614G dose E484K effective ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay exhibit individual L452R less limit of detection Multiple N501Y neutralization assays neutralization test neutralizing activities Neutralizing activity Neutralizing antibodies neutralizing antibody performed plaque reduction neutralization Plaque reduction neutralization test PRNT RBD reagent reagents respiratory SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus target Testing testing antibody throughput Vaccine variants volunteers [DOI] 10.1021/acs.analchem.1c04383 PMC 바로가기 [Article Type] Article
Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection Research Published on 2022-02-072022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Analysis Anti-RBD IgG antibody assays asymptomatic infection asymptomatic infections Beta circulating variant collected convalescent coronavirus disease COVID-19 declined decrease Delta detectable disease illness onset Immunity Infection laboratory confirmation longitudinal majority microneutralization Mild NAb Neutralization assay Neutralizing activity neutralizing antibody neutralizing response pandemic peaked persistent plasma sample pseudotyped reduced response Result reveal SARS-CoV-2 significantly symptomatic tested These data titre titres undetectable vaccination Vaccination strategies variants [DOI] 10.1038/s41564-021-01051-2 [Article Type] Research
Robust validation and performance comparison of immunogenicity assays assessing IgG and neutralizing antibodies to SARS-CoV-2SARS-COV-2에 대한 IgG 및 중화 항체를 평가하는 면역 원성 분석의 강력한 검증 및 성능 비교Research Article Published on 2022-02-072022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 spike protein antibody Antibody titer Antibody titers approach Benchmarking calibrated convalescent coronavirus coronavirus disease Coronavirus disease 2019 correlation criteria cross-reactivity demonstrated domain donors ECL functional functional immune response human serum IgG immune response immune responses immunogenicity immunogenicity assay immunogenicity assays immunogenicity data Immunoglobulin Immunoglobulin G International international units Meso Scale Discovery microneutralization MNT MSD multiplex Neutralizing activity Neutralizing antibodies neutralizing antibody nucleocapsid outcome Precision Protein Quantitative RBD RBD protein RBD proteins reference standard regimens Reporting respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike SARS-CoV-2 vaccination scale seasonal coronaviruses selectivity sera serologic severe acute respiratory syndrome Coronavirus specificity spike and RBD proteins Spike protein tested the WHO vaccinated individuals vaccination Vaccine Vaccines virus were assessed [DOI] 10.1371/journal.pone.0262922 PMC 바로가기 [Article Type] Research Article
Development and multi-center clinical trials of an up-converting phosphor technology-based point-of-care (UPT-POCT) assay for rapid COVID-19 diagnosis and prediction of protective effects신속한 CovID-19 진단 및 보호 효과의 예측을위한 UPT-POCT (Up-Converting Phosphor Technology-CARE) 분석의 개발 및 다중 센터 임상 시험Clinical Trial Published on 2022-02-032022-09-01 Journal: BMC Microbiology [Category] COVID19(2023년), Fulltext, MERS, SARS, 임상, 진단, 치료기술, 치료제, [키워드] Accuracy antibody Chain Reaction China clinical trial clinically Concentration correlation COVID-19 COVID-19 cases COVID-19 diagnosis COVID-19 patient COVID-19 patients Critical cross-reaction cross-reactions Cutoff defined development ELISA evaluated healthy hospital inactivated indicated intensity lateral flow lateral flow strip microneutralization Microneutralization assay NAb titer NAb titers Neutralizing activity neutralizing antibody OD value OD values Patient performed POCT point-of-care Polymerase chain reaction test positive protective effect Protective effects quantitation Quantitative RBD RBD-specific antibodies RBD-specific antibody RBD-specific total antibodies Reactions Receptor-binding domain recovered patient recovered patients Result reveal reverse transcriptase SARS-CoV-2 SARS-CoV-2 spike protein Sensitivity and specificity serum sample serum samples Seven significantly specific antibodies Spike protein supplementary material test results the antibody the receptor-binding domain total antibodies total antibody Up-conversion phosphor technology vaccinee vaccinees viruses was determined [DOI] 10.1186/s12866-022-02450-z PMC 바로가기 [Article Type] Clinical Trial
Sequentially immune-induced antibodies could cross-neutralize SARS-CoV-2 variants순차적으로 면역 유도된 항체는 SARS-CoV-2 변이체를 교차 중화할 수 있습니다Article Published on 2022-02-012022-09-11 Journal: Animal models and experimental medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody B.1.1.529 collected cross-neutralize cross-neutralize SARS-CoV-2 cross-neutralizing delta variant Delta variants demonstrated dose geometric mean geometric mean titer geometric mean titers GMT GMTs Human human sera Humoral immunity immune Immunity in vitro inactivated Inactivated vaccine lead Mutation neutralization Neutralization antibody neutralization titers Neutralizing activity neutralizing antibody omicron Omicron variant PiCoVacc Protein raised Recombinant protein reduction in SARS-CoV-2 SARS-CoV-2 variant sequentially immune. sera Spike protein target the spike protein vaccination Vaccine variant wild type ZF2001 [DOI] 10.1002/ame2.12216 PMC 바로가기 [Article Type] Article
Aggregation of high‐frequency RBD mutations of SARS‐CoV‐2 with three VOCs did not cause significant antigenic driftResearch Article Published on 2022-01-282022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 293T cell aggregation amino acid change antigenic antigenicity Beta cell–cell fusion convalescent sera convalescent serum decrease E484K Gamma immune immunogens Infectivity K417N mAbs monoclonal antibody MOST multiple mutations Mutation mutations N439K N501Y neutralization Neutralizing activity outbreak Pseudotyped virus pseudovirus RBD RBD mutation receptor‐binding domain reduce SARS‐CoV‐2 SARS‐CoV‐2 sera significantly single mutant the RBD the spike protein V367F Vaccine Vaccine development variant variants variants of concern Vero cells VoC VOCs [DOI] 10.1002/jmv.27596 PMC 바로가기 [Article Type] Research Article