Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome as a Presentation of Coronavirus Disease 2019Emergency Medicine Published on 2020-04-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] av nodal blockers blockade bradycardia brash syndrome Coronavirus disease 2019 COVID-19 end-organ damage failure global pandemic hyperkalemia novel coronavirus disease predominant presentation renal renal failure Respiratory failure sars-cov-2 (severe acute respiratory syndrome coronavirus -2) Shock syndrome triggered while [DOI] 10.7759/cureus.7816 PMC 바로가기 [Article Type] Emergency Medicine
A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19)Infectious Disease Published on 2020-04-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE ACE2 Angiotensin-converting enzyme ARDS Basic science Biochemistry can be used candidate CDC center Chloroquine clinical Clinical course Clinical practice clinical trial Comprehensive Control Coronavirus disease 2019 Corticosteroid COVID-19 COVID19 described diagnostic discharge disease course epidemiological evaluate evaluated Evolution experiment explain Factor Frequency global pandemic H1N1 hindrance hospital ibuprofen Infection information inhibitors limitation literature literature review LOPINAVIR AND RITONAVIR management manuscript media MERS Micronutrient mRNA-1273 vaccine multiple parameter nonsteroidal anti-inflammatory drug NSAIDS outbreak pandemic Phylogeny presentation Prophylaxis Public health interventions remdesivir (GS-5734) review risk factor SARS-CoV-2 self-quarantine severe acute respiratory infection Spread statistical Stratification Symptom the SARS-CoV-2 virus the WHO therapy Treatment viral genome virion Vitamin C [DOI] 10.7759/cureus.7560 PMC 바로가기 [Article Type] Infectious Disease
Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY Trial아프리카에서 HIV에 대한 늦은 발표: REALITY 시험의 표현형, 위험 및 위험 계층화Advanced HIV Disease Published on 2018-04-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] Africa age albumin Antiretroviral therapy ART baseline CD4 CD4 count CD4 counts children clinical Cox regression died enrolled Fat mass Fever FIVE Follow-up grip strength group Health Organization hemoglobin high mortality highest HIV Human immunodeficiency virus identify Immunocompromised Immunosuppression individual infected individuals Intensive investigated Kenya laboratory feature median Mobility Mortality neutrophil neutrophil count neutrophil counts Older Older age Participants Patient Phenotypes Platelet poor mobility predictor presentation problem problems Prophylaxis reduced Registration remaining group Result self-care symptom burden Trial Uganda vomiting weight loss white cell World Health Organization Zimbabwe [DOI] 10.1093/cid/cix1142 PMC 바로가기 [Article Type] Advanced HIV Disease
A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other CausesResearch Article Published on 2016-11-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] acute respiratory disease acute respiratory illness Adverse adverse outcome cause city clinical clinical feature Clinical outcome clinically Comparative CoV demographics diabete diarrhoea eight eligible Factor for inclusion HCW Health Health care health care workers hospital illness indicated Infection King laboratory characteristics Laboratory test MERS MERS patient MERS patients MERS-CoV MERS-CoV infection Middle East nine Older age Other outcome Patient PCR positive presentation presenting respiratory risk factor RT-PCR Saudi Arabia significantly syndrome tested variable [DOI] 10.1371/journal.pone.0165978 PMC 바로가기 [Article Type] Research Article
Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patientsResearch Published on 2016-05-072022-11-01 Journal: Critical Care [Category] Coronavirus, MERS, [키워드] Admission age Analysis APACHE II applied bilateral pulmonary infiltrates Clinical data clinical feature coronavirus death Epidemic greater high mortality rate ICU independent risk factor Infection intensive care Invasive mechanical ventilation males mechanical ventilation MERS-CoV MERS-CoV infection Middle East morbidity and mortality observation period Older organ dysfunction outcome Patient patients patients died polymerase chain presentation reported Respiratory failure Respiratory samples respiratory syndrome coronavirus Result reverse transcription risk factor Saudi Arabia severity SOFA score supplementary material syndrome tachypnea therapy Vasopressor [DOI] 10.1186/s13054-016-1303-8 PMC 바로가기 [Article Type] Research
ImmunoChip Study Implicates Antigen Presentation to T Cells in NarcolepsyImmunoChip 연구는 기면증에서 T 세포에 대한 항원 제시를 의미합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Alpha Antigen presentation antigen processing Author Autoimmune autoimmune and inflammatory diseases autoimmune attack Autoimmune disease Cathepsin H chromosome chromosome 6 class compared Consensus Control controls CTSH deficiency disease pathogenesis disease risk encoded protein encoded proteins environmental exposure European Gene Genes genome-wide significance genotyped genotyping high-density genotyping platform HLA HLA class II HLA DQB1*06:02 Human human leukocyte antigen hypocretin cells ImmunoChip immunological synapse implicated in addition to individual inflammatory disease Inflammatory diseases Interaction leukocyte Ligand loci mechanism Narcolepsy narcolepsy-hypocretin deficiency OX40L pathophysiology pathway post-infectious autoimmune presentation progression recent selective significantly study variant Support susceptibility T cell T cell receptor T cell response T cells the disease TNFSF4 TNFSF4/OX40L tumor necrosis tumor necrosis factor unique variant variants while [DOI] 10.1371/journal.pgen.1003270 PMC 바로가기 [Article Type] Research Article
Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다Research Article Published on 2011-06-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type [DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article
The Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike proteinHypothesis Published on 2005-02-102022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition biochemically Cell Coronaviruses cytoplasmic cytoplasmic tail decrease different domain Effect examined expressed expression genetics Genome homologue Hypothesis Impact in vitro in vivo infected cell Infection Interaction mechanism methodology modulate motif Open reading frame other coronaviruses pathway presentation Protein Replication reported respiratory resulting RNA SARS-CoV severe shown significantly Spike protein Testing the spike protein undergo unique viral infection viral pathogenesis Viral protein viral spread [DOI] 10.1186/1743-422X-2-5 PMC 바로가기 [Article Type] Hypothesis