Early COVID-19 therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in outpatient settings significantly improved COVID-19 outcomes compared to known outcomes in untreated patientsResearch article Published on 2021-09-012022-10-05 Journal: New Microbes and New Infections [Category] 신약개발, 임상, 치료기술, [키워드] age Analysis antiandrogen approach article baseline clinical equipoise Clinical outcome Combination Comorbidity confirmed case Control control groups COVID-19 death demonstrated disease disease severity drug combination dutasteride early-stage COVID-19 employment enrolled ethical concern FIVE group groups Hospitalization hospitalizations Hydroxychloroquine improvement in viral Ivermectin manifestation mechanical ventilation nitazoxanide outcome Patient pharmacological Placebo positive result precluded prevented prospective observational study proxalutamide raised randomized clinical trial RCTs reduction Respiratory complications safety profile SARS-CoV-2 Sex significantly spironolactone tested therapy untreated patient untreated patients [DOI] 10.1016/j.nmni.2021.100915 [Article Type] Research article
Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individualsArticle Published on 2021-08-282022-11-01 Journal: Science Immunology [Category] COVID-19, MERS, SARS, [키워드] activated Activation activity Adults Amino acid amino acids CD4 CD8 Cell cell fate complex Control cytosolic deficiency Degradation effector T cell ENhance expression favor follicular Genes Immunity impair in vitro inactivation increased expression independent individual individuals Infection inhibiting late endosome leucine lysosomal lysosome Lysosomes mammalian memory T memory T cells mTORC1 negative feedback loop Older plasma membrane platform prevented proliferative Rapamycin recall reduced response responses resulting SARS-CoV-2 peptide SLC7A5 sustained T cell T cell activation T cell response T helper cell terminally differentiated TFEB transcription factor transfer VPS39 [DOI] 10.1126/sciimmunol.abg0791 PMC 바로가기 [Article Type] Article
How many hospitalizations has the COVID-19 vaccination already prevented in São Paulo?Comments Published on 2021-08-272022-10-31 Journal: Clinics [Category] COVID-19, MERS, SARS, [키워드] COVID-19 vaccination Hospitalization prevented [DOI] 10.6061/clinics/2021/e3250 PMC 바로가기 [Article Type] Comments
Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2: a rare clinical reactionResearch Published on 2021-08-252022-10-31 Journal: European Journal of Medical Research [Category] COVID-19, MERS, [키워드] administration affected collected coronavirus disease COVID-19 COVID‐19 cutaneous manifestation database Delayed dermatitis dose edema Erythema female first dose hospital hospitals individual individuals Inflammation lesions Manifestations mRNA vaccination mRNA-1273 vaccine occurred pathophysiology Patient prevented Rash reaction reported required resolved Result risk factor SARS-CoV-2 second dose Side effect Steroids the vaccine [DOI] 10.1186/s40001-021-00557-z PMC 바로가기 [Article Type] Research
The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension – Study design and challenges during the COVID-19 pandemicRandomized Controlled Trial Published on 2021-08-232022-10-04 Journal: Clinics [Category] SARS, 임상, [키워드] Analysis antihypertensive medication blood pressure brachial calculated co-morbidities co-primary endpoint COVID-19 pandemic CPAP defined Effect evaluate evaluated Final hypertension include kidney male medication multicenter nasal obstructive sleep apnea occur organ damage OSA outcome pandemic parameter Patient Placebo positive airway pressure post-hoc prevented Randomized controlled trial Sample size secondary Study design Treatment Trial uncontrolled uncontrolled hypertension unique [DOI] 10.6061/clinics/2021/e2926 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Improvement of Air Quality and Associated Mortality during the COVID-19 Lockdown in One Megacity of China: An Empirical StrategyArticle Published on 2021-08-182022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Air pollution average caused changed changes China Concentration confounder COVID-19 COVID-19 pandemic death deaths declined Difference-in-differences Effect effort Emissions Government Health Health risk Impact improvement lockdown lockdown policy Measures megacity Mortality prevented Quality reduce reduced resulting risk Strategy [DOI] 10.3390/ijerph18168702 PMC 바로가기 [Article Type] Article
On limits of contact tracing in epidemic controlResearch Article Published on 2021-08-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] applied assumption Contact tracing deterministic model diagnosed early stage Effect Epidemic Evolution fraction limit measure Poland prevented quarantine Reproduction number social distancing measures the epidemic transmission parameters [DOI] 10.1371/journal.pone.0256180 PMC 바로가기 [Article Type] Research Article
The Impact of Structural Inequities on Older Asian Americans During COVID-19Public Health Published on 2021-08-162022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] aging American Americans approach Asian Asian Americans Care Community contribute coronavirus COVID-19 COVID-19 mortality COVID-19 testing eligible greater Health highlight Impact IMPROVE Inclusion intersectionality Older Older adults pandemic Perspective populations prevented racism receiving Region Research rising risk social determinant subpopulation Transmission vaccination [DOI] 10.3389/fpubh.2021.690014 PMC 바로가기 [Article Type] Public Health
The New Generation h DHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human CoronavirusesArticle Published on 2021-08-142022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] hDHODH inhibitor addition Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent biosynthesis pathway broad-spectrum antiviral cells cellular combination treatment contribute coronavirus CoV COVID-19 CoVs de novo develop development DHODH drug effective embryonic enzyme Generation Human in vitro infections inhibited inhibitor kidney organoid lack New organoids Other pandemic Pandemics predicted prevented Probability pyrimidine biosynthesis Replication reversed SARS-CoV-2 stem cells therapeutic intervention Threats uridine zoonotic disease [DOI] 10.3390/microorganisms9081731 PMC 바로가기 [Article Type] Article
How to Reduce the Transmission Risk of COVID-19 More Effectively in New York City: An Age-Structured Model StudyMedicine Published on 2021-08-132022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addressed age age-structured model calibrated the model chain confirmed case Contact COVID-19 COVID-19 epidemic death develop diagnosed effective evaluate group Hospitalized Infection Keeping lockdown restriction Markov mobile cabin hospital Model New York New York City parameter Prevent prevented public health reduce reduced released releasing strategies remained risk of COVID-19 second wave significantly social distancing the epidemic Transmission was reduced [DOI] 10.3389/fmed.2021.641205 PMC 바로가기 [Article Type] Medicine