Adapting the design of a Web-based decision support clinical trial during the COVID-19 pandemicRandomized Controlled Trial Published on 2021-10-232022-10-04 Journal: Trials [Category] MERS, SARS, 임상, [키워드] Affair Care changes in clinical care clinical trial concerning conducted COVID-19 COVID-19 pandemic decision Department equity highlight impacted internal and external Intervention knowledge lung cancer Lung cancer screening pandemic primary care protocol public health raised Randomized controlled trial RCT recruitment Regulation Research Screening Shared decision-making significantly Study design Study protocol subsequent Support System unique Validity veteran [DOI] 10.1186/s13063-021-05700-z PMC 바로가기 [Article Type] Randomized Controlled Trial
A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®면역 저하 환자에서 승인된 SARS-CoV-2 백신을 평가하기 위한 시험 플랫폼: mRNA 백신 Comirnaty®와 COVID-19 mRNA를 비교하는 파일럿 시험을 위한 첫 번째 하위 프로토콜 Vaccine Moderna®Study Protocol Published on 2021-10-212022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] Antibody Response approaches approved baseline clinical trial Cohort cohorts collected data confidence interval contagious Controlled trial coronavirus coronavirus SARS-CoV-2 COVID-19 disease Efficacy Efficacy and safety eligible Endpoint endpoints favor feasibility first vaccination flexible foundation Frame groups highest HIV HIV patient HIV patients Immunocompromised Immunocompromised patient Immunocompromised patients information Intervention Medical conditions Missing data mRNA mRNA vaccine multicenter non-inferiority margin Open-label Organ transplant outcome pandemic Patient patient recruitment Pfizer/BioNTech pilot study Platform trial positive antibody response primary clinical outcome Program proportion protocol randomization Randomized Randomized controlled trial Randomized controlled trial, HIV RCT reached reactivity receiving recipients required Sample size SARS-CoV-2 SARS-CoV-2 vaccine Science Statistical power STCS Switzerland Transplant treatment arm Trial trial platform Trial registration two-sided type I type I error Vaccine Wuhan Wuhan, China [DOI] 10.1186/s13063-021-05664-0 PMC 바로가기 [Article Type] Study Protocol
Uses of equipoise in discussions of the ethics of randomized controlled trials of COVID-19 therapiesCOVID-19 요법의 무작위 통제 시험의 윤리에 대한 토론에서 평등의 사용Research Published on 2021-10-212022-09-10 Journal: BMC Medical Ethics [Category] Fulltext, MERS, SARS, 임상, [키워드] analyzed applied article articles barrier categories COVID-19 COVID-19 pandemic COVID-19 RCTs COVID-19 research effective therapy Equipoise evaluated expectation Google Scholar Guidance highlight Patient physician Primary outcome provide question randomised controlled trial randomization Randomized controlled trial Randomized controlled trials RCT RCTs Research Ethics researcher resolved Result screened searched second Seven supplementary material Support Therapeutic benefit Therapies therapy were assessed widespread [DOI] 10.1186/s12910-021-00712-5 PMC 바로가기 [Article Type] Research
Intervening on Trust in Science to Reduce Belief in COVID-19 Misinformation and Increase COVID-19 Preventive Behavioral Intentions: Randomized Controlled TrialRandomized Controlled Trial Published on 2021-10-142022-10-04 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 임상, [키워드] 95% CI adjusted odds ratio Affect age aggregate analyses approach assigned belief collected contribute Controlled covariate COVID-19 develop Evidence examined Gender Identifier increase increase in indirect effect infodemic Intention intervene Intervention intervention effect misinformation objective outcome parallel-group participant pilot study platform Prevent Prolific Randomized controlled trial Randomly RCT recruit reduced Registration report Research Result Science The effect size Trust trust in science turn Two-arm [DOI] 10.2196/32425 PMC 바로가기 [Article Type] Randomized Controlled Trial
Behavioural activation to prevent depression and loneliness among socially isolated older people with long-term conditions: The BASIL COVID-19 pilot randomised controlled trialRandomized Controlled Trial Published on 2021-10-122022-10-04 Journal: PLoS Medicine [Category] MERS, SARS, 임상, [키워드] 1.26 95% CI Activation adjusted Adults adverse events age AMD Anxiety approach approaches assessment baseline behavioural benefit blind collected comparison concealed conditions confidence interval covariate COVID-19 COVID-19 pandemic demonstrated Depression depressive symptom Depressive symptoms Effect effective Effectiveness emotional Evidence examined feasible female Follow-up form GAD groups Health impacted Infection Intervention Isolation limitations loneliness Long-term condition LTC LTCs mean difference median Mental mitigate occurred offered Older outcome pandemic participant PHQ-9 physical pilot study populations preliminary finding Prevent primary care primary clinical outcome Primary outcome PROTECT Psychological psychological Impact Quality of life randomised randomised controlled trial Randomised trial RCT receiving recruited recruitment reduced reduction in remote replicate Replication researcher risk robust scale second secondary outcome severity shown social isolation Standard deviation Statistical power Support tested the median treatment allocation Trial turn Type unlikely was measured white [DOI] 10.1371/journal.pmed.1003779 PMC 바로가기 [Article Type] Randomized Controlled Trial
Vaccine Refusal in the Czech Republic Is Associated with Being Spiritual but Not Religiously AffiliatedArticle Published on 2021-10-102022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95% confidence interval association being Combination contribute COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine Czech Republic deleterious effect Effectiveness Evidence group help investigated Odds ratio participated Prevent RCT reduction in refusal Religiosity religious conspiracy beliefs significantly Spirituality understanding vaccination Vaccine vaccine intention [DOI] 10.3390/vaccines9101157 PMC 바로가기 [Article Type] Article
Traditional Chinese medicine as an adjunctive therapy for mild and common COVID-19 A systematic review and network meta-analysis온화하고 일반적인 CovID-19에 대한 보조 요법으로서의 전통 중국 의학, 체계적인 검토 및 네트워크 메타 분석Meta-Analysis Published on 2021-10-082022-08-31 Journal: Medicine [Category] MERS, SARS, 임상, 치료제, [키워드] 95%CI adjuvant therapy analyzed best bias risk China Chinese Clinical efficacy clinical symptom Computed tomography conducted confidence confidence interval control group Controlled trial conversion rate coronavirus disease Coronavirus disease 2019 cough country COVID-19 COVID-19 patients curative curative effect disease effective Effectiveness Efficacy and safety evaluate evaluated fatigue Fever IMPROVE Infrastructure Mild Network meta-analysis non-randomized novel coronavirus pneumonia Odds ratio Patient patients present Prevent R software Randomized controlled trial Randomized controlled trials RCT RCTs Registration registration number Research retrospective cohort Science searched sensitivity sensitivity analysis severe disease significantly Stata statistical statistical analysis Symptom Symptoms systematic review TCM technology therapy Traditional Chinese medicine Treatment VIP [DOI] 10.1097/MD.0000000000027372 PMC 바로가기 [Article Type] Meta-Analysis
A Web-Based Intervention (Germ Defence) to Increase Handwashing During a Pandemic: Process Evaluations of a Randomized Controlled Trial and Public Dissemination팬데믹 기간 동안 손 씻기를 늘리기 위한 웹 기반 개입(세균 방어): 무작위 대조 시험 및 공개 배포의 프로세스 평가Randomized Controlled Trial Published on 2021-10-052022-09-10 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 비임상, 임상, [키워드] 95% CI adaptation affected attrition automated Behavior breath Cold colds Controlled coughing COVID-19 digital intervention dissemination dropped Effect Engagement Enrollment enrolment evaluation studies flu framework general practices Germ Guidance hands handwashing health emergency help increase Increases increases in Infection Influenza Intention Internet Intervention ISRCTN registry mean difference Medical Research Council objective Open Access outbreak pandemic participant Prevent prevention Process Public Randomized controlled trial RCT reached Registration replicated reported Research respiratory respiratory tract infection Respiratory tract infections respiratory viruses Result selected sneezing Spread swine flu Transmission Trial Usage user virus washing website [DOI] 10.2196/26104 PMC 바로가기 [Article Type] Randomized Controlled Trial
A Protocol for a Systematic Review and Meta-Analysis of Mind–Body Modalities to Manage the Mental Health of Healthcare Workers during the COVID-19 EraProtocol Published on 2021-10-032022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] Bia conducted Confidence intervals Continuous data Controlled clinical trial coronavirus disease COVID-19 database Effectiveness HCW HCWs Health healthcare personnel healthcare worker homogeneous IMPROVE Intervention intervention study manuscript mean difference mental health Meta-analysis mind–body therapies Mindfulness-based modality pandemic Pandemics peer-reviewed performed physical populations Quality Quality of life Randomized RCT RCTs review risk ratio searched systematic review therapy worker [DOI] 10.3390/healthcare9101320 PMC 바로가기 [Article Type] Protocol
Efficacy and safety of hydroxychloroquine as pre-and post-exposure prophylaxis and treatment of COVID-19: A systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trials.Research article Published on 2021-10-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 신약개발, 임상, 치료법, 치료제, [키워드] 95% CI 95% confidence interval adverse event Anti-inflammatory antiviral activity Antiviral effect blinded clinical benefit clinical study close contact Cochrane guideline continuous variable COVID-19 death demonstrated dichotomous variable Effect Efficacy and safety element eligibility evaluate Evidence finding FIVE fixed funding funding source Gastrointestinal symptom HCQ heterogeneity Hospital stay Hospitalization hospitalized patient Hydroxychloroquine immunomodulatory in vitro incidence increased risk individual Invasive mechanical ventilation lack mean difference medication Meta-analysis moderate outcome Outpatient patients patients with COVID-19 performed Placebo placebo-controlled positive Prevent Prophylactic Prophylaxis random-effects model randomized clinical trial randomized clinical trials RCT RCTs receiving reported risk SARS-CoV-2 SARS-COV-2 infection systematic review to define Treatment Trial was used Web of Science website were used with COVID-19 [DOI] 10.1016/j.lana.2021.100062 [Article Type] Research article