Total antioxidant capacity as a marker of severity of COVID-19 infection: Possible prognostic and therapeutic clinical applicationCOVID-19 감염의 중증도 마커로서의 총 항산화 용량 : 가능한 예후 및 치료 임상 적용Article Published on 2022-04-012022-08-31 Journal: Journal of medical virology [Category] 바이오마커, [키워드] activity antioxidant antioxidant enzyme blood sample Blood samples catalase causative pathogen collected Concentration control group COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Defense dismutase Enzymes healthy individual healthy individuals healthy volunteer infected individual infected individuals Infection investigated marker Mild Mild disease nitric oxide oxidative stress Pathogenesis pathogenesis of SARS-CoV-2 Patient patients with COVID-19 Predictive prognostic Research SARS-COV-2 infection sera serum serum levels severe disease severely ill patients severity of COVID-19 statistically significant Superoxide Superoxide Dismutase susceptible TAC therapeutic Total total antioxidant capacity Variation was performed were measured with mild disease [DOI] 10.1002/jmv.27500 PMC 바로가기 [Article Type] Article
Antibody evasion properties of SARS-CoV-2 Omicron sublineagesSARS-CoV-2 오미크론 하위 계통의 항체 회피 특성Article Published on 2022-04-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody antigenic bebtelovimab caused comparable coronavirus Efficacy Evolution except for exhibited include lead monoclonal antibodies monoclonal antibody monoclonal antibody therapy mRNA vaccine Neutralizing activity neutralizing monoclonal antibodies neutralizing monoclonal antibody omicron Omicron variant Patient polyclonal sera Prevalence recipient recipients refs reported respiratory retained S309 SARS-CoV-2 sera severe acute respiratory syndrome Coronavirus Sotrovimab spike glycoprotein Surveillance tested therapy unique Vaccines variant wild-type SARS-CoV-2 [DOI] 10.1038/s41586-022-04594-4 PMC 바로가기 [Article Type] Article
Sensitivity and specificity of 14 SARS-CoV-2 serological assays and their diagnostic potential in RT-PCR negative COVID-19 infections14가지 SARS-CoV-2 혈청학적 분석의 민감도 및 특이성 및 RT-PCR 음성 COVID-19 감염에서의 진단 가능성Case Reports Published on 2022-04-012022-09-11 Journal: Acta clinica Belgica [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] added applied assays calculated Case report complement COVID-19 COVID-19 case COVID-19 diagnosis COVID-19 infection cross-reactive detect diagnose Diagnosis diagnosis of COVID-19 diagnostic evaluate Final gold gold standard help highest IgG illustration Interpretation lack molecular Molecular diagnosis molecular test Patient performance positive presenting remained respiratory respiratory sample Respiratory samples retrospective retrospective cohort RT-PCR SARS-CoV-2 SARS-CoV-2 test selected sensitivity Sensitivity and specificity sera serological Serological assay serology serology testing specificity symptom onset tested Viral viral loads [DOI] 10.1080/17843286.2020.1861885 PMC 바로가기 [Article Type] Case Reports
Evasion of vaccine-induced humoral immunity by emerging sub-variants of SARS-CoV-2SARS-CoV-2의 새로운 하위 변종에 의한 백신 유도 체액 면역 회피Article Published on 2022-04-012022-09-11 Journal: Future Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] accelerate Beta Beta variant contributed COVID-19 dose Effectiveness Efficacy emergence escape mutant evaluate exhibited genomic global public health highest Humoral immunity Imdevimab immune Immune escape material mRNA vaccine Mu variant mutant mutants neutralization neutralization test Neutralizing activity Neutralizing antibodies no decrease omicron Pfizer/BioNTech Phenotypic analysis Receptor-binding domain retained SARS-CoV-2 SARS-CoV-2 variant selection pressure sera shown strain Strains Surveillance tested the receptor-binding domain vaccination Vaccine vaccine effectiveness were used [DOI] 10.2217/fmb-2022-0025 PMC 바로가기 [Article Type] Article
Outbreak of SARS-CoV-2 B.1.617.2 (delta) variant in a nursing home 28 weeks after two doses of mRNA anti-COVID-19 vaccines: evidence of a waning immunitymRNA 항-COVID-19 백신 2회 접종 후 28주 만에 요양원에서 SARS-CoV-2 B.1.617.2(델타) 변종 발생: 면역 약화의 증거Article Published on 2022-04-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 48 hour 48 hours 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Anti-spike anti-Spike IgG Antibody Units B.1.617.2 B.1.617.2 SARS-CoV-2 variant binding antibody unit booster dose collected coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 Delta diagnosed dose Effectiveness Evidence expressed Fisher exact test health worker health workers higher risk IgG Immunity index case Infection Italy Lineage material mRNA mRNA vaccine Neutralizing nursing home nursing home residents outbreak Quantitative Relative risk resident respiratory resulting risk RT-PCR SARS-CoV-2 SARS-COV-2 infection second dose Sequencing sera serum severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 severe disease titre vaccination Vaccine vaccine effectiveness variant waning immunity was determined was measured was performed WHO [DOI] 10.1016/j.cmi.2021.12.013 PMC 바로가기 [Article Type] Article
Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies백신 유도 및 치료 항체에 의한 중화에 대한 SARS-CoV-2 Omicron 변이체의 내성 증가Article Published on 2022-04-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody Antibody neutralization applied benefit BNT162b2 booster concern decrease disease severity Donor donors effective Effectiveness Efficacy Emergency use highlight immunization Increased incubated lentivirus Lilly luciferase luciferase activity luminometer maintain mapped Moderna monoclonal antibodies monoclonal antibody monoclonal antibody therapies monoclonal antibody therapy mutated neutralization Neutralizing NIH obstacle omicron Omicron variant Pfizer preventing infection PROTECT protein structure pseudotype pseudotyped lentiviruses Regeneron Resistance mutation resistance mutations SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant sera serum Sotrovimab Spike protein T cells target cells the vaccine the vaccines therapeutic Therapies therapy titre Vaccine vaccine efficacy variant was measured [DOI] 10.1016/j.ebiom.2022.103944 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Delta and delta derivatives impact on neutralization of Covishield recipient seraSARS-CoV-2 델타 및 델타 파생 상품이 Covishield 수혜자 혈청 중화에 미치는 영향Article Published on 2022-04-012022-09-11 Journal: The Journal of Infection [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Abstract AY.1 Covishield Delta Delta AY.1 derivative neutralization SARS-CoV-2 sera variant variant of concern [DOI] 10.1016/j.jinf.2022.02.018 PMC 바로가기 [Article Type] Article
Assessment of T-cell Reactivity to the SARS-CoV-2 Omicron Variant by Immunized Individuals면역화된 개인에 의한 SARS-CoV-2 오미크론 변이체에 대한 T 세포 반응성 평가Article Published on 2022-04-012022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] age assessment blood sample Blood samples Care CD4+ cell CD4+ cells CD4+ T cell CD4+ T cells CD8+ T cells Cell cellular component cellular immunity cohort study conducted contagious decrease determine enrolled foundation Frequency full-length protein group Health Health care highlight Hospitalization immune immune protection immune system Immunity immunized individual Infection Italy Lymphocytes median mutated Mutation Neutralizing new SARS-CoV-2 no significant differences omicron Omicron variant outcome participant peptide peptides reactive reactivity reduced reduction Region regions Rome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera severe disease significant difference significantly Spike protein Stimulation T cells T-cell T-cell immunity tested the SARS-CoV-2 the spike protein vaccination variant variant of SARS-CoV-2 Volunteer volunteers women [DOI] 10.1001/jamanetworkopen.2022.10871 PMC 바로가기 [Article Type] Article
A Faster, Novel Technique to Detect COVID-19 Neutralizing AntibodiesCOVID-19 중화 항체를 탐지하는 더 빠르고 새로운 기술Article Published on 2022-03-272022-09-11 Journal: Medical science monitor : international medical jo [Category] MERS, SARS, 진단, 치료기술, [키워드] Analysis antibody AZ vaccine collected correlation COVID-19 COVID-19 pandemic criterion Data analysis dataset demonstrated detect develop Efficacy Efficiency ELISA ELISA assay exploration faster first and second dose Healgen indicated lateral flow immunoassay leads LFIA test NAb Neutralizing antibodies neutralizing antibody novel participant Participants Pearson platform predict promoted Research second dose sera specimen spectrometer Spread technique Vaccine vaccine efficacy vaccine trial [DOI] 10.12659/MSM.935812 PMC 바로가기 [Article Type] Article
ACE2 Serum Levels as Predictor of Infectability and Outcome in COVID-19COVID-19의 감염 가능성 및 결과 예측자로서의 ACE2 혈청 수준Article Published on 2022-03-232022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] ACE2 analysed Angiotensin II antibodies antibody Antibody Response Biomarker cellular Cohort COVID-19 COVID-19 disease determinant generate Health care worker high risk IgG antibody infected patient Infection lentivirus Level negative control neutralization neutralize Patient predict PROTECT pseudotyped respiratory symptom risk SARS-COV-2 infection sera seronegative seropositive serum Serum level severity significantly higher soluble ACE2 subject subjects Subtypes Symptoms tested uninfected virus [DOI] 10.3389/fimmu.2022.836516 PMC 바로가기 [Article Type] Article