transcriptional – Page 20 – Communicable Diseases Research

Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus

삼투성 항상성의 순환 di-AMP 조절은 B군 연쇄상 구균에서 필수적입니다

Research Article

Published on 2018-04-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans

기능적 다양화는 칸디다 알비칸스에서 MED2 상동체의 유전자 패밀리 확장을 수반합니다

Research Article

Published on 2018-04-092022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 3’ end accompany addressed affected aggregation biological function Biological functions buffer Candida Candida albican Candida albicans Cell Combination commensal complex component conserved contribute contributed correlated did not produce difficulty domain duplication Effect entire gene example expansion expression facilitate family members function functional functions Gene duplication gene families gene family generate Genes genetic diversity greater growth homolog identify INDEL individual gene individual genes induced Infection influence involved killing Macrophage mapped mechanism mediator Mutation natural selection neofunctionalization occurred opportunistic pathogen organism overlap pathogen pathogenic phenotype Phenotypes phenotypic phenotypic effect polymorphic site Positive selection promoter provide question regulate regulated Regulation Regulatory repeated selective pressure sequence sequence similarity Specific strain Strains subfunctionalization subunit sucrose traits transcriptional transcriptional regulator unique Variability variant virulence were assessed yeast
[DOI] 10.1371/journal.pgen.1007326 PMC 바로가기 [Article Type] Research Article

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space

Hsf1 수준을 조정하면 고갈이 Hsp90 기능을 손상시키고 과발현이 대상 공간을 확장하여 독특한 곰팡이 형태 발생 프로그램을 구동합니다.

Research Article

Published on 2018-03-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence bypassing Candida albican Candida albicans cellular changes in chaperone complex conserved Control Critical defend Depletion developmental dose-dependent driving elevated temperature environmental cue environmental cues Fever fluctuation form functional fungal fungal pathogen Gene Expression growth Heat shock highlight Host host response hosts Hsf1 Hsp90 Human impairing induce Infection mammalian mechanism microorganism microorganisms modulate molecular morphogenesis observé overexpression pathogen Pathogens physiological temperature positive provide regulate Regulation required respond survival target temperature transcription factor transcriptional tuning virulence yeast
[DOI] 10.1371/journal.pgen.1007270 PMC 바로가기 [Article Type] Research Article

Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans

Wor1은 Candida albicans에서 일반적인 공동 억제 인자 Tup1의 억제를 통해 불투명한 세포 운명을 설정합니다.

Research Article

Published on 2018-01-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence Affect Affinity purification analyses Analysis approach Author bypass Candida Candida albican Candida albicans carbon carbon source carbon sources Cell cell fate cells colonization colonize commensal complex protein explain expressed facilitate Factor function functions fungal Genetic gut microbiota Host identify individuals induce Loss maintain mass spectrometry mass spectroscopy master regulator mechanism molecular Morphological occur pathogen pathogenic phenotypic plasticity positive feedback promoter Proteins provide Region regulated Regulation regulatory circuit repression repressor serious infection serious infections stability starting switching temperature transcriptional transcriptional repressor undergo white Wor1
[DOI] 10.1371/journal.pgen.1007176 PMC 바로가기 [Article Type] Research Article

PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzae

PKA 활성은 Magnaporthe oryzae에서 MoSfl1에 의한 균사 성장 및 부착기 형성 억제를 완화하는 데 필수적입니다.

Research Article

Published on 2017-08-142022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation affinity Affinity purification Author C-terminal CAMP catalytic subunit cellular processe characterized co-IP conidia conidiation conserved Critical Deletion downstream eukaryotic cell eukaryotic cells Extracellular function functional functions Fusarium growth growth defect hyphal Infection insertion Interaction invasive involved IP assays loss-of-function mutation loss-of-function mutations Magnaporthe mutant mutants Mutation overlapping Pathogenesis pathway penetration Phosphorylation PKA produced purification reduced regulate regulated repressor residue response signaling pathway significantly strain Strains suppress suppressed suppression suppressor suppressors transcription factor transcriptional Treatment was reduced yeast
[DOI] 10.1371/journal.pgen.1006954 PMC 바로가기 [Article Type] Research Article

The nucleoid occlusion protein SlmA is a direct transcriptional activator of chitobiose utilization in Vibrio cholerae

nucleoid occlusion protein SlmA는 Vibrio cholerae에서 키토비오스 활용의 직접적인 전사 활성제입니다.

Research Article

Published on 2017-07-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation activity addition aquatic environment bind Catabolism cause Cell cell division ChiS chitin chitobiose cholera cholerae composed Critical disaccharide disease disparate disrupt downstream drinking water Evolution expression function Gene regulation gene transfer horizontal gene Horizontal gene transfer identify implicated in vivo Interaction involved locus mechanism member mutant pathogen persistence Point mutation point mutations promoter Protein Proteins regulated Regulation regulator required TetR the marine transcriptional transcriptional activation transcriptional regulator transfer transposon utilization Vibrio cholerae water
[DOI] 10.1371/journal.pgen.1006877 PMC 바로가기 [Article Type] Research Article

Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses

Research Article

Published on 2017-06-022022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] 24 hours antiviral genes approach can be used caused Cell cellular response changes changes in coronavirus Defense dependent on disease Effect elicited epithelial cell expression Gene Expression Host host gene expression host response hours post-infection in vitro study in vivo Infection influenza A virus lung epithelial cell Lung epithelial cells mechanism mice microarray analysis Mild moderate mounted murine overlapping parameters Pathogenesis peaked respiratory tract respiratory viral infection respiratory viral infections respiratory virus response rhinovirus severity signature tissue remodeling transcription factor transcriptional Treatment type I interferon unique virus virus infection viruses
[DOI] 10.1371/journal.pone.0178408 PMC 바로가기 [Article Type] Research Article

Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans

인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명

Research Article

Published on 2017-04-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type
[DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease

유전 변이는 점막 염증 질환에서 T-bet 결합 및 유전자 발현을 변경합니다

Research Article

Published on 2017-02-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect alleles Alter alteration Arthritis association autoimmune conditions Autoimmune disease Autoimmune diseases Autoimmunity autoinflammatory disease binding binding site Cancer CD4+ T cell CD4+ T cells celiac disease certainty ChIP ChIP-seq condition contribute Crohn’s disease decreased expression disease disease-associated distal DNA elements environmental factors eQTL examined exons expression expression quantitative trait locus Gene Expression Genetic Genetic polymorphism genetic polymorphisms Genetic variant genetic variants Genetic variation Genome-wide association studies helper cell heterozygous identify IL18RAP immune response in vitro in vivo increased risk individual Infection Inflammatory inflammatory disease Inflammatory diseases Lineage locus majority mechanism modulating molecular mechanism mucosal nucleotide Other polarization polymorphism protective immunity Protein psoriasis Quantitative quantitative trait locus Region regulate Regulatory represse reveal rheumatoid arthritis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs subsequent susceptibility susceptibility to infections T cell T cells T helper cell TBX21 Th1 transcription factor transcription factors transcriptional ulcerative colitis underlie variant
[DOI] 10.1371/journal.pgen.1006587 PMC 바로가기 [Article Type] Research Article

Transcription Factors Encoded on Core and Accessory Chromosomes of Fusarium oxysporum Induce Expression of Effector Genes

Fusarium oxysporum의 코어 및 액세서리 염색체에 인코딩된 전사 인자는 이펙터 유전자의 발현을 유도합니다

Research Article

Published on 2016-11-172022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Accessory accessory chromosome accessory chromosomes activate autonomous bind binding site chromatin chromatin condensation chromosome chromosomes colonisation connection conserved constitutive promoter core core genome determine DNA binding effector effectors ENCODE Evolution example expression extreme facilitate Factor FTF1 FTF2 fungal fungi Fusarium GC content Gene Expression Genes Genome genomic genomic region homolog homolog FTF2 homologous Host independent induce Infection Interaction investigated maintain motif motifs nine occurred oligonucleotide oligonucleotide arrays outcome overlapping pathogen Pathogenesis pathogenic pathogenicity Pathogens predicted promoters reference strain Region required RNAseq analysis secreted Sge1 specificity strain Strains tomato Transcription transcription factor transcription factor gene transcription factor genes transcription factors transcriptional transcriptionally transfer transferred transposon up-regulated virulence yeast
[DOI] 10.1371/journal.pgen.1006401 PMC 바로가기 [Article Type] Research Article