Identification of Persuasive Antiviral Natural Compounds for COVID-19 by Targeting Endoribonuclease NSP15: A Structural-Bioinformatics ApproachArticle Published on 2020-12-012022-10-30 Journal: Molecules [Category] COVID-19, [키워드] active site binding Biosynthesis CDOCKER clinical investigation Combination Compound COVID-19 database docking Ecophysiology effective endoribonuclease Final Genome genomic identification investigated molecular docking molecular dynamics natural natural compounds nonstructural protein Nsp15 performed product replicate Replication residue RNA RNA virus SARS-CoV-2 SARS-CoV-2 treatment targeting viral life cycle virion Virtual screening virus [DOI] 10.3390/molecules25235657 PMC 바로가기 [Article Type] Article
Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to The Treatment of SARS-CoV-2Review Published on 2020-12-012023-07-05 Journal: Microbial pathogenesis [Category] SARS, [키워드] coronavirus glycosylation PTMs Tunicamycin virion [DOI] 10.1016/j.micpath.2020.104586 PMC 바로가기 [Article Type] Review
Analyzing the dominant SARS-CoV-2 transmission routes toward an ab initio disease spread modelARTICLES Published on 2020-12-012022-10-28 Journal: Physics of Fluids [Category] COVID-19, [키워드] analyzed average basic reproduction number calculate calculated caused Combination Combined Contact cough determine Dilution disease spread dominant droplet droplets encapsulate Evolution Frequency highest identifying Infection infection rate infectious dose Inhaled initial molecular nuclei pandemic physical Probability reduce Research SARS-CoV-2 transmission sensitivity shown susceptible the SARS-CoV-2 virus Transmission transmission route Variation Viral load virion virus while [DOI] 10.1063/5.0034032 PMC 바로가기 [Article Type] ARTICLES
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivitySARS-CoV-2 스파이크 단백질 D614G 돌연변이는 비리온 스파이크 밀도와 감염성을 증가시킵니다.Article Published on 2020-11-262022-09-10 Journal: Nature Communications [Category] SARS, 변종, [키워드] ACE2 ACE2-expressing cell ACE2-expressing cells Alter binding Cell D614G D614G mutation D614G variant functional increase less mutated neutralization produced pseudovirus pseudoviruses S protein S proteins S-protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity spike-protein virion Virology Virus-like particle virus-like particles [DOI] 10.1038/s41467-020-19808-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomographyArticle Published on 2020-11-182022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] accumulated acute respiratory syndrome characteristic characterized cisternae complexes conformational change coronavirus COVID19 Critical Cryoelectron microscopy Cryoelectron tomography cylindrical cytoplasm double-stranded RNA Extracellular filament Genome highly pathogenic induce mechanism membrane membrane curvature membranes occur other coronaviruses packaged pandemic recruitment replicate Replication representing ribonucleoprotein RNA RNA secondary structures S trimer SARS-CoV-2 SARS-CoV-2 infected cell steric tomography vesicles viral replication virion virion assembly virus virus replication β-coronavirus [DOI] 10.1038/s41467-020-19619-7 PMC 바로가기 [Article Type] Article
A 3.4-Å cryo-electron microscopy structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particlesResearch Article Published on 2020-11-172022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] ACE2 activating addition antibody binding biochemically cause children coronavirus Cryo-electron microscopy cryo-EM domain drugs ectodomain explain family Coronaviridae glycosylation HCoV-NL63 homologous Human human coronavirus NL63 immunocompromised individuals Mild NL63 Particles pathogen provide purified receptor receptors respiratory diseases Respiratory illness S trimer SARS-CoV-1 SARS-CoV-2 shown Spike protein spike trimer Spread structures trimer upper respiratory symptom viral entry virion virus particle [DOI] 10.1017/qrd.2020.16 PMC 바로가기 [Article Type] Research Article
Static all-atom energetic mappings of the SARS-Cov-2 spike protein and dynamic stability analysis of “Up” versus “Down” protomer statesResearch Article Published on 2020-11-102022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] ACE-2 receptor acting Amino acid Analysis backbone atom binding characteristic conducted conserved COVID-19 Critical cross demonstrated determine disrupting distal domain dominant example experimental structure human epithelial cells inactive include independent Interaction interactions intrachain involved Molecular dynamics simulation Mutation NTD pandemic performed Point mutation prefusion Protein provided proximal RBD Receptor binding domain reduced reported residue responsible S1 domain SARS-CoV-2 sequence spike Spike protein stability Static the RBD the SARS-CoV-2 trimeric turn Van der Waals Variation virion virus [DOI] 10.1371/journal.pone.0241168 PMC 바로가기 [Article Type] Research Article
Cell Clearing Systems as Targets of Polyphenols in Viral Infections: Potential Implications for COVID-19 PathogenesisReview Published on 2020-11-102022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] acting acute lung injury acute respiratory distress acute respiratory syndrome alteration alterations Anti-inflammatory Antiviral ARDS autophagy baicalin cellular Clearing coagulation dysfunction Compound contribute cordycepin coronavirus Course COVID-19 Cytopathic effect Diseases Disseminated intravascular coagulation Effect endothelial feature Frame hallmark herbal compound Host host cell Immunoproteasome impairment in viral include Infection infections Inflammation inflammatory mediator Invasion kaempferol metabolic pathway MODS modulate multiple organ dysfunction neurological Novel coronavirus Occurrence outcome pandemic Pathogenesis pathway pharmacological Pneumonia polyphenol Potential quercetin Replication reported researcher respiratory viruses resveratrol SARS-CoV-2 SARS-COV-2 infection subcellular syndrome System systemic inflammation target Therapeutic approach therapy Transmission viral infection virion virus widespread [DOI] 10.3390/antiox9111105 PMC 바로가기 [Article Type] Review
Long-Term Modeling of SARS-CoV-2 Infection of In Vitro Cultured Polarized Human Airway EpitheliumResearch Article Published on 2020-11-062022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome airway airway epithelia airway epithelial damage airway epithelium Basal cell basolateral side cause caused characterized ciliated ciliated cell club cell Club cells confirmed case contribute coronavirus coronavirus disease COVID-19 COVID-19 patients Culture damaged demonstrated dominant donors epithelial epithelial cell epithelial damage epithelium exhibit expression fatality Goblet cell goblet cells HAE highlight Human human airway epithelia Human airway epithelium human airways in vitro in vitro model in vivo independent infect Infection infections initiate long-lasting long-term infection lung maintain mimicking modeling pandemic progeny proliferation recurrent infection replicate Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 replication Support tested the SARS-CoV-2 tight junction Viral load virion virus virus infection virus replication ZO-1 [DOI] 10.1128/mBio.02852-20 PMC 바로가기 [Article Type] Research Article
Cold atmospheric plasma for SARS-CoV-2 inactivationLetters Published on 2020-11-012022-10-28 Journal: Physics of Fluids [Category] COVID-19, [키워드] approaches atmospheric Cold Contact coronavirus coronavirus disease COVID-19 effective human infection inactivation Infection plasma Prevent Safe SARS-CoV-2 Transmission Treatment virion virus transmission [DOI] 10.1063/5.0031332 PMC 바로가기 [Article Type] Letters