A new generation of vaccines based on alphavirus self-amplifying RNAReview article Published on 2020-10-012022-10-05 Journal: Current opinion in virology [Category] SARS, 비임상, [키워드] Administered alphavirus Antigen approach Cationic lipid cellular response clinical trial conventional vaccine DNA Electroporation expression vector high expression level humoral Immunity in vivo induce initiated mRNA mRNA vaccine Pathogens polymers profiles responses RNA SARS-CoV-2 shown vaccinate Vaccine viral particle [DOI] 10.1016/j.coviro.2020.08.003 [Article Type] Review article
Trends and targets of various types of stem cell derived transfusable RBC substitution therapy: Obstacles that need to be converted to opportunity다양한 형태의 줄기세포 유래 수혈적혈구 대체요법의 동향 및 목표: 기회로 전환되어야 할 장애물Review Published on 2020-10-012022-09-11 Journal: Transfusion and apheresis science : official journ [Category] 비임상, [키워드] approach artificial artificial intelligence Bioreactors Blood Blood Group blood supply breath Cell cellular clinical trial Combination complex Compliance COVID-19 Critical Culture dependency Donor Efficiency embryonic employment example expansion Expansion media GMP GMP regulatory processes hematological Hematopoietic stem cell hematopoietic stem cells highlight in vitro In-vitro induced Induced pluripotent stem cell life maintenance media metabolic pathway metabolic pathways metabolite metabolites New obstacle outbreak overcome pandemic produced RBC RBCs regenerative regenerative medicine Regulatory required Safe stability STEM stem cell stem cells target Transfusable RBC bioproducts. transfusion trend Variability [DOI] 10.1016/j.transci.2020.102941 PMC 바로가기 [Article Type] Review
Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19Short communication Published on 2020-10-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 신약개발, 치료제, [키워드] a potassium ion channel in heart ACCdrug accumulation accumulate accumulating acid/base ionisation constant addition antiviral activity antiviral effects antivirals applied approach assessments available data C-C chemokine receptor type 5 CADcationic amphiphilic drug cationic amphiphilic drug CCR5C-C chemokine receptor type 5 cells clinical trial combating Compound Coronaviruses COVID-19 COVID-19 pandemic criteria disease displaying distribution coefficient of non-charged species of compound between octanol and water drug drug accumulation drugs endoplasmatic reticulum endosomal pathway endosome Endosomes ERendoplasmatic reticulum Evidence example help hERGhuman Ether-à-go-go-Related Gene highest human Ether-à-go-go-Related Gene identify in silico inherent interfere knowledge logPdistribution coefficient of non-charged species of compound between octanol and water lysosome Lysosomes membrane molecular outbreak Patient pharmacokinetic Phospholipidosis physicochemical pKaacid/base ionisation constant PLDphospholipidosis QSARquantitative structure activity relationship quantitative structure activity relationship Registered reported Spread Support tested Vdvolume of distribution viral infection volume of distribution [DOI] 10.1016/j.biopha.2020.110582 [Article Type] Short communication
Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis planRandomized Controlled Trial Published on 2020-10-012022-10-05 Journal: Acta Anaesthesiologica Scandinavica [Category] 임상, [키워드] acute respiratory syndrome all-cause mortality blinded caused clinical clinical trial Confidence intervals coronavirus disease Coronavirus-2 Corticosteroid COVID COVID-19 days alive Effects Evidence hospital Hydrocortisone hypoxic respiratory failure intensive care intention to treat interim analysis International intravenous mechanical ventilation median Mortality on mechanical ventilation outcome oxygen pandemic Patient patients with COVID-19 Placebo populations Primary outcome protocol Quality of life randomised receiving reduce renal replacement therapy reported secondary serious adverse reaction severe hypoxia statistical analysis Statistical analysis plan stratified Support Trial use of corticosteroid viral clearance [DOI] 10.1111/aas.13673 PMC 바로가기 [Article Type] Randomized Controlled Trial
A survey of 434 clinical trials about coronavirus disease 2019 in China2019년 중국에서 코로나바이러스 질병에 관한 434건의 임상시험에 대한 설문조사Article Published on 2020-10-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 임상, [키워드] China clinical trial coronavirus disease [DOI] 10.1002/jmv.25779 PMC 바로가기 [Article Type] Article
A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunctionResearch article Published on 2020-10-012022-10-05 Journal: Brain, behavior, and immunity [Category] SARS, 임상, [키워드] acute respiratory distress airway alveolar ARDS BALF bronchial cause caused CCL2 CCR5 Cell changes in characterized clinical trial cough COVID-19 COVID-19 patient curated database dataset disease disease severity driver drug EGFR expressed Factor high risk highlight Human immune Immune cell infect Inflammation inhibitors Interaction interactions Intervention lung Mild Mortality Neuron neuronal Onset pathology patients pharmacological plasma Pneumonia promote Protein pulmonary disease pulmonary dysfunction receptor reduce reveal rheumatoid arthritis RNA sequencing SARS-COV-2 infection SARS-CoV-2 viral infection SARS-CoV-2 virus sensory neuron Severe case severe COVID-19 Shortness of breath Single Cell syndrome the disease treat [DOI] 10.1016/j.bbi.2020.05.078 [Article Type] Research article
An overview of the safety assessment of medicines currently used in the COVID-19 disease treatmentReview article Published on 2020-10-012022-10-05 Journal: Food and chemical toxicology : an international jo [Category] 치료법, [키워드] adverse effect Chloroquine Clinical data clinical trial Combination concerning Coronavirus infection COVID-19 COVID-19 disease disease drug drug combination Efficacy and safety evaluate Health status illness interferon Medicine Medicines monotherapy New coronavirus other diseases pandemic Registered Remdesivir reported retinal damage risk Ritonavir Safety assessment SARS-CoV-2 selected the patient therapeutic strategy therapy toxic effect toxic effects Toxicity treat Treatment umifenovir with COVID-19 World Health Organization [DOI] 10.1016/j.fct.2020.111639 [Article Type] Review article
Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical studyClinical Trial Published on 2020-10-012022-10-04 Journal: Transfusion and apheresis science : official journ [Category] SARS, 임상, 치료법, [키워드] all-cause mortality approved claimed clinical clinical study clinical trial Confirmed COVID-19 infection control group convalescent plasma convalescent plasma group Convalescent plasma therapy Cost effectiveness COVID-19 COVID-19 infection COVID-19 patient COVID-19 positive patient discharged Efficacy Evidence hospital Hospital stay Hospitalization intubation Length management mortality rate multicenter New coronavirus outcome Patient patient group patients plasma provide Registered required Result SARS-CoV-2 significantly lower Support therapy Treatment Vaccine virus infection [DOI] 10.1016/j.transci.2020.102875 PMC 바로가기 [Article Type] Clinical Trial
Achieving effective informed oversight by DMCs in COVID clinical trialsDiscussion Published on 2020-10-012022-10-05 Journal: Journal of clinical epidemiology [Category] SARS, 임상, [키워드] accumulated ARMS benefit clinical settings clinical trial clinical trials conducted coronavirus coronavirus epidemics COVID COVID-19 COVID-19 pandemic Data monitoring committee DMC effective Evidence HIV/AIDS include Interim analyses Intervention measure MONITOR Platform trial PROTECT provided public health randomized clinical trial regimen risk Structure Trial [DOI] 10.1016/j.jclinepi.2020.07.001 [Article Type] Discussion
Application of methylene blue -vitamin C –N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trialResearch article Published on 2020-10-012022-10-05 Journal: European journal of pharmacology [Category] 임상, 치료법, [키워드] Activation acute respiratory syndrome Administered application approved cascade catastrophic cause clinical trial complications contribute coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Critical Critically ill cysteine cytokine drug FDA FIVE healthy individuals hypoxia ICU induce Inflammatory inflammatory state Interrupting kill Macrophage macrophage activation mechanism metabolite Methylene blue microbial N-acetyl cysteine Nitrate nitric oxide other diseases oxidative stress Pathogenesis Patient patients phenotype pro-inflammatory protocol significantly increased Stress survival rate the disease the patient therapeutic effect therapeutic option Treatment vicious cycle Vitamin C were measured [DOI] 10.1016/j.ejphar.2020.173494 [Article Type] Research article