Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responsesPrefusion-stabilized SARS-CoV-2 Spike 면역원을 인코딩하는 Ad26 벡터 기반 COVID-19 백신은 강력한 체액 및 세포 면역 반응을 유도합니다Article Published on 2020-09-282022-09-10 Journal: NPJ Vaccines [Category] 변종, 비임상, 임상, [키워드] Ad26 Ad26.COV2.S best binding breath Cellular immune response cellular immunity cleavage clinical trial coronavirus coronavirus S coronavirus S protein COVID-19 COVID-19 vaccine Critical demonstrated development effective element elicited etiologic agent evaluated folded protein furin furin cleavage site Heterologous hinge region humoral Humoral immunity IFN-γ induce Intervention membrane-bound mice Mutation Neutralizing Neutralizing antibodies neutralizing antibody non-neutralizing antibody observation peptide peptides Phase I prefusion conformation proline prolines prophylactic measure prophylactic measures Protein S protein S protein-based vaccine SARS-CoV-2 SARS-CoV-2 vaccine shown signal peptide signal peptides spike Substitution substitutions Th1 the S protein translated Vaccine Vaccines Viral viral infection viral replication viral surface wild-type [DOI] 10.1038/s41541-020-00243-x PMC 바로가기 [Article Type] Article
Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review바이러스 수명 주기의 진입 후 단계를 대상으로 하는 잠재적인 Anti-SARS-CoV-2 치료제: 종합 검토Review Published on 2020-09-262022-09-10 Journal: Viruses [Category] SARS, 비임상, [키워드] (RdRp breath chemical structures clinical investigation clinical trial clinical trials clinically Comprehensive coronavirus coronavirus disease COVID-19 decrease described Dexamethasone dihydroorotate dehydrogenase early stage Effect effective EIDD-2801 facilitate Favipiravir Health care Health care system health care systems identify include Infection life life cycle limit M pro main protease mechanism molecular monoclonal antibodies mortality rate pandemic Papain-like protease pharmaceutical companies polypeptides Potential presenting Prevent protease RdRP Remdesivir Research review RNA-dependent RNA polymerase SARS-CoV-2 scientist severity of COVID-19 Small molecules Stage Structure target Therapeutics Treatment Viral viral infection viral life cycle Viral protein Viral proteins Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.3390/v12101092 PMC 바로가기 [Article Type] Review
The impact of COVID-19 on intestinal flora A protocol for systematic review and meta analysis4700 Published on 2020-09-252022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] abstracts Analysis articles association Case-control caused causes China Chinese clinical trial Cochrane Library Cohort studies comparator conducted Consensus content Coronavirus disease 2019 COVID-19 Cross-sectional studies database databases Digital disease dissemination eligible Ethical approval Ethics Evidence exposure finding for inclusion gastrointestinal symptoms heterogeneity homogeneous Internet intestinal flora investigated item journal Meta-analysis meta-regression Novel coronavirus observational study outbreak OVID pandemic participant Patient peer-reviewed Population proportion protocol public health prevention random-effect reported Reporting required resolved respiratory tract infection review risk of bia subject systematic review Treatment with COVID-19 World Health Organization [DOI] 10.1097/MD.0000000000022273 PMC 바로가기 [Article Type] 4700
Things must not fall apart: the ripple effects of the COVID-19 pandemic on children in sub-Saharan Africa모든 것이 무너져서는 안 됩니다: COVID-19 전염병이 사하라 사막 이남 아프리카 어린이들에게 미치는 파급 효과Review Published on 2020-09-242022-09-10 Journal: Pediatric Research [Category] MERS, SARS, 말라리아, 유전자 메커니즘, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach approaches caused Cell child health children clinical trial clinical trials co-morbidities communicable Complication condition conflict coronavirus coronavirus disease Coverage COVID-19 COVID-19 pandemic Critical diarrhea disease disease control disease outbreaks Diseases Effect Epidemiology Factor Health health systems highlight HIV identify Impact Intervention lack malaria mitigate morbidities Non-communicable disease non-communicable diseases Novel coronavirus novel coronavirus disease Outbreaks outcome pandemic participant pediatric persists Pneumonia Prevention and control proportion public health public health programs Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus sickle cell Sickle cell disease Significant sub-Saharan Africa Tuberculosis undernutrition zero [DOI] 10.1038/s41390-020-01174-y PMC 바로가기 [Article Type] Review
The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 PatientsReview Article Published on 2020-09-242022-10-29 Journal: Stem Cells International [Category] COVID-19, [키워드] acute respiratory disease acute respiratory distress acute respiratory syndrome adhere administration affected agent alveolar inflammation ARDS Bone marrow Cell cell-based therapies clinical trial coronavirus COVID-19 COVID-19 patient COVID-19 patients disease Efficacy epithelia example Exosome highlight lung injuries MSC MSCs pandemic pathological condition patients Pneumonia Potential Quality control respiratory tract risk SARS-CoV-2 shown significantly lower STEM stem cell stem cells Support syndrome therapeutic therapeutic potential therapy treating COVID-19 World Health Organization [DOI] 10.1155/2020/8835986 PMC 바로가기 [Article Type] Review Article
Immunomodulation Through Low-Dose Radiation for Severe COVID-19: Lessons From the Past and New DevelopmentsReview Published on 2020-09-222022-10-31 Journal: Dose-Response [Category] COVID-19, [키워드] Care clinical trial clinically COVID-19 COVID-19 crisis COVID-19 cytokine storm COVID-19 pandemic COVID-19 patient Cytokine storm demonstrated development disease downregulation Effectiveness Efficacy elicited Evidence expected hyperinflammatory state immunomodulating immunomodulation Inflammation Inflammatory diseases initial lesson Low-dose radiation mechanism New oncology Pneumonia Proinflammatory cytokine putative mechanism radiation therapy Radiotherapy Research risk Severe COVID-19 pneumonia therapy Toxicity translate Treatment [DOI] 10.1177/1559325820956800 PMC 바로가기 [Article Type] Review
The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019Review Published on 2020-09-212022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] absence acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome alleviate Antiviral ARDS arise changed clinical trial common condition coronavirus coronavirus disease Coronavirus infections Coronavirus-2 COVID-19 critically ill patients curtail death disease drug Effect Host host-response immune response immunomodulatory properties Infection intensive care Mesenchymal stromal cells Middle East MSC MSCs multiple sclerosis Osteoarthritis outbreak pandemic Patient potential treatments reduce regenerative Safe SARS-CoV-2 SARS-COV-2 infection Seven severity Spread stromal cell syndrome therapy Treatment Vaccine while [DOI] 10.1186/s12967-020-02532-4 PMC 바로가기 [Article Type] Review
Anti-Rheumatic Drugs for the Fight Against the Novel Coronavirus Infection (SARSCoV-2): What is the Evidence?Review Published on 2020-09-212022-10-31 Journal: Mediterranean Journal of Rheumatology [Category] COVID-19, [키워드] “cytokine storm” ACE2 receptor addition Against anti-cytokine antimalarial Asymptomatic cause clinical trial Colchicine Course COVID-19 COVID-19 infection COVID-19 symptoms current cytokine Cytokine storm Cytokines death develop drug dysregulated elderly expressed high risk Hydroxychloroquine IL-1 IL-6 immune system immunoglobulins intensive care intravenous male medical condition novel occur Other Patient patients plethora positive-sense single-stranded RNA pro-inflammatory cytokine producing Protein pulse reduce respiratory cells SARS-CoV-2 selected severe complications severely infected patient shown smoker spike Spike protein therapy Tocilizumab Treatment ventilatory support virus [DOI] 10.31138/mjr.31.3.259 PMC 바로가기 [Article Type] Review
Aspirin with or without statin in the treatment of endotheliitis, thrombosis, and ischemia in coronavirus diseaseMajor Article Published on 2020-09-212022-10-28 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID-19, MERS, SARS, [키워드] age Aspirin benefit Case series changes clinical evolution clinical trial Comorbidity complementary contributed coronavirus disease COVID-19 diagnosis of COVID-19 discharged Endothelial dysfunction Endotheliitis Endothelium evaluate Evolution Hospitalization Hydroxymethylglutaryl-CoA Reductase Inhibitors hypothese Ischemia laboratory-confirmed medication Patient poor prognosis Prevent Prophylaxis reported resolved risk factor secondary bacterial stage III statin Support survival Symptom Symptoms the disease Therapeutic approach therapy thrombosis thrombotic Treatment vascular disease vessels [DOI] 10.1590/0037-8682-0472-2020 PMC 바로가기 [Article Type] Major Article
Sex differences in severity and mortality from COVID-19: are males more vulnerable?Review Published on 2020-09-182022-10-28 Journal: Biology of Sex Differences [Category] COVID-19, SARS, [키워드] addition clinical trial coronavirus Coronavirus disease 2019 COVID-19 COVID-19 severity Critical disease disease severity Effect Factor female females Gender global efforts help immune response immune system immunosuppressive effects indicate indicated Infection infection control information male molecular mechanism Mortality mortality rate outcome Pathogenesis Pathogens required Research response severity severity of COVID-19 Sex Sex difference Sex hormones shown therapy viral clearance viral infection Viral load viral RNA clearance with COVID-19 [DOI] 10.1186/s13293-020-00330-7 PMC 바로가기 [Article Type] Review