Protease inhibitor monotherapy for long-term management of HIV infection: a randomised, controlled, open-label, non-inferiority trialHIV 감염의 장기 관리를 위한 프로테아제 억제제 단독 요법: 무작위, 대조, 공개, 비열등성 시험Articles Published on 2015-09-142022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 adverse event age Antiretroviral therapy ART baseline benefit block CD4 Cell Clinical management Clinical outcome clinical risk Combination combination treatment computer-generated Controlled darunavir defined drug drug resistance enrolled finding Frequency funding Genetic GRADE grade 3 HIV HIV infection inferiority inhibitor Intention intention to treat international standard Kaplan-Meier Kaplan-Meier analysis Lopinavir maintain management monotherapy non-inferiority non-inferiority margin non-inferiority trial number once daily Open-label parallel-group participant positive Pragmatic preserved Primary outcome Probability Protease inhibitor protease inhibitors public sector randomisation randomisation list randomised Randomly rebound Registered Ritonavir Serious Adverse Events shown Standard stratified suppressed the patient therapy toxic effects Treatment treatment failure Trial Viral Viral load virus [DOI] 10.1016/S2352-3018(15)00176-9 PMC 바로가기 [Article Type] Articles
A cluster randomized controlled trial to increase the availability and acceptability of voluntary medical male circumcision in Zambia: The Spear and Shield Project잠비아에서 자발적인 의료 남성 할례의 가용성과 수용 가능성을 높이기 위한 클러스터 무작위 대조 시험: The Spear and Shield ProjectArticle Published on 2015-06-172022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI adjusted odds ratio adverse event adverse events assigned baseline Care center Cluster community health Community health centers conditions conducted Control Controlled trial counseling death expressed female finding funding Health Health care HIV HIV infection HIV prevention Intervention likelihood male men MOST Odds ratio participant Participants Participation Patient performed post-intervention Prevalence prevention programs Primary outcome randomization Randomized controlled trial Randomly reported Result Shield significant increase Spear statistician stratified study participation supply Support tested Trial registration [DOI] 10.1016/S2352-3018(15)00042-9 PMC 바로가기 [Article Type] Article
Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trialHIV-1에 감염된 건강한 성인에서 후보 결핵 백신 MVA85A의 안전성, 면역원성 및 효능: 무작위, 위약 대조, 2상 시험Articles Published on 2015-03-012022-09-06 Journal: The Lancet. Respiratory Medicine [Category] Communicable Disease, [키워드] 1:1 95% CI absence active tuberculosis adverse event Antigen antigen 85A antigen 85A-specific T-cell response antiretroviral Antiretroviral therapy assigned assist baseline baseline CD4 block blocks booster Cape CD4 count CD4 counts Cell clinical defined detect detectable Developing disease double-blind effective Efficacy eligible Eligible participants enrolled enrolment European Evidence evidence of expressing finding first vaccination foundation funding gold greater Group allocation had no healthy HIV-1 HIV-1 infection immunogenic immunogenicity include increased risk Infection injection intradermal injections investigators isoniazid isoniazid prophylaxis Laboratory latent tuberculosis latent tuberculosis infection M tuberculosis Measures Melinda Gate Melinda Gates modified vaccinia virus MVA85A Mycobacterium tuberculosis nine no evidence of Nurses occurred outcome participant partnership peaked per-protocol analysis per-protocol population Phase 2 phase 2 trial Placebo placebo group placebo-controlled positive Potential Prophylaxis protocol QuantiFERON QuantiFERON-TB Gold In-Tube randomisation randomised Randomly receive receiving Registered reported Safe Safety safety analysis second vaccination secondary Secondary outcomes sequence Serious Adverse Event Serious Adverse Events significant increase South Africa stratified subset T-cell Response the placebo group therapy town Treatment Trial Tuberculosis tuberculosis disease tuberculosis vaccine undetectable vaccination Vaccine vaccine efficacy vaccine-induced immune response Viral Viral load Wellcome Trust were assessed [DOI] 10.1016/S2213-2600(15)00037-5 PMC 바로가기 [Article Type] Articles
Effects of Spirulina platensis supplementation on lipid profile in HIV–infected antiretroviral naïve patients in Yaounde – Cameroon: a randomized trial study야운데 - 카메룬에서 HIV에 감염된 항레트로바이러스 경험이 없는 환자의 지질 프로필에 대한 스피루리나 플라텐시스 보충제의 효과: 무작위 시험 연구Research Published on 2014-12-132022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] abnormality age alteration antiretroviral Atherosclerosis average average age balanced diet baseline BMI body fat body mass body mass index cardiovascular cardiovascular diseases cardiovascular dysfunction cardiovascular risk factors CD4 cholesterol conducted contributing to CVD defined determine disease dyslipidemia Effect Factor fat distribution female Food Intake HDL-C HDL-cholesterol HIV HIV+ antiretroviral naïve include infections Inflammation insulin insulin resistance LDL-C LDL-cholesterol lipid profile Local local food majority metabolic syndrome multicentre naïve participant Patient patients public health Quantitative Randomized randomized trial recruited reported Result screened significant decrease significant increase significantly single-blind Spirulina platensis syndrome the patient Total cholesterol Triglyceride triglycerides variable weight were assessed with HIV [DOI] 10.1186/1476-511X-13-191 PMC 바로가기 [Article Type] Research
The Effect of Therapeutic Lumbar Punctures on Acute Mortality From Cryptococcal Meningitis치료적 요추 천자가 크립토코커스 수막염으로 인한 급성 사망률에 미치는 영향HIV/AIDS Published on 2014-12-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] acute mortality adjusted relative risk Altered mental status ART association baseline cerebrospinal fluid COAT trial Conducting cryptococcal meningitis Cryptococcal Optimal ART Timing cryptococcosis CSF CSF fungal death diagnose Diagnosis Effect elevated Epidemiology Follow-up HIV Human immunodeficiency virus ICP immunodeficiency virus individual initial initial pressure intracranial pressure investigated Lumbar puncture lumbar punctures magnitude management Meningitis Mortality occurred Patient randomization Randomized receiving Relative risk risk screened South Africa sub-Saharan Africa subject subsequent survival Symptoms therapeutic LP therapeutic LPs therapeutic lumbar punctures time of death Trial Uganda was related [DOI] 10.1093/cid/ciu596 PMC 바로가기 [Article Type] HIV/AIDS
Findings from the SASA! Study: a cluster randomized controlled trial to assess the impact of a community mobilization intervention to prevent violence against women and reduce HIV risk in Kampala, UgandaSASA의 발견! 연구: 우간다 캄팔라에서 여성에 대한 폭력을 예방하고 HIV 위험을 줄이기 위한 지역사회 동원 개입의 영향을 평가하기 위한 클러스터 무작위 통제 시험Research Article Published on 2014-07-312022-08-09 Journal: BMC Medicine [Category] 임상, [키워드] 95% CI 95% confidence interval adjusted baseline Cluster Community Community mobilization conducted Controlled trial Cross-sectional surveys defined Drivers East Africa eight Evidence finding Follow-up Gender based violence greater HIV Impact evaluation impacts implementation intention-to-treat analysis Intervention Intimate partner violence men outcome physical post intervention Prevalence Prevent Primary outcome protocol public health random Random sample Randomized controlled trial receive reduce replicated responses Result risk risk ratio Sex significantly significantly lower Study protocol sub-Saharan Africa supplementary material Trial registration Uganda Violence Violence prevention while woman women [DOI] 10.1186/s12916-014-0122-5 PMC 바로가기 [Article Type] Research Article