clinical trial – Page 208 – Communicable Diseases Research

Therapeutic Options Against the New Coronavirus: Updated Clinical and Laboratory Evidences

Medicine

Published on 2020-09-152022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Effects of Licorice on clinical symptoms and laboratory signs in moderately ill patients with pneumonia from COVID-19: A structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-09-152022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 Adverse reaction age allergy Anti-inflammatory Antibody test anticipated antiviral therapy assigned Bandar Abba Bandar Abbas Blinding Breastfeeding C-reactive protein Chest computed tomography chronic heart disease clinical clinical study clinical symptom Clinical symptoms clinical trial company conducted Confirmed Control control group Corticosteroids COVID-19 criteria Critical diagnosis of SARS-CoV-2 Diseases disorders dissemination diuretics dose drugs dry cough education Effect element evaluated feature Features female patient Fever glycyrrhiza history hospital Hospitalization hypertension ill patient incidence Infection inhibitor intervention group Iran Laboratory Laboratory signs licorice liquorice liver lymphocytopenia male Medical Sciences Ministry of Health Moderate COVID-19 number objective Open-label outcome parallel-group participant Patient pharmaceutical Placebo Pneumonia polymerase chain Primary outcome protocol random randomization randomize Randomized Randomized controlled trial regimen Registered registry renal Sample size screened secondary outcome selective serotonin reuptake inhibitor Seven single-center standard treatment status Study protocol therapeutic Thyroid time tiredness Treatment treatment arm Trial university Version website X-ray
[DOI] 10.1186/s13063-020-04706-3 PMC 바로가기 [Article Type] Letter

A quadruple blind, randomised controlled trial of gargling agents in reducing intraoral viral load among hospitalised COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-09-142022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] administration age antiviral therapy approved asked assumption blind blinded carried Chemical Chemotherapy clinical clinical trial COVID COVID-19 COVID-19 patient COVID-19 positive patients Cytokine analysis cytokine profile determine dissemination edentulous Effectiveness element eligibility assessment excluded expected explained female FIVE Flow gargles Glasgow coma score group hospitalised hydrogen hypertonic identify IFN-γ IL-10 IL-2 IL-4 IL-6 Immunological test Inc. inclusion criteria Intervention Intubated Karachi Laboratory laboratory-confirmed lesion male Mild moderate disease mucosal nasal Nasal lavage number objective outcome parallel group participant Patient PCR test positive controls Primary outcome product protocol provided Purposive sampling quantitative PCR Radiotherapy randomised randomised controlled trial real time reducing reduction in Registered reported Research Research question salivary Sample size sealed Standard status study group Study protocol subject Symptoms the patient TNF-α treated Trial unit university university hospital Viral load website
[DOI] 10.1186/s13063-020-04634-2 PMC 바로가기 [Article Type] Letter

Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic Review

Review

Published on 2020-09-112022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] animal models Anti-inflammatory benefit building Cancer Cancer therapy cardiac cardio-oncology clinical outcomes clinical trial coronavirus 2019 (COVID-19) coronavirus disease COVID-19 COVID-19 infection COVID-19 therapy Cytokine release syndrome decrease drug Efficacy effort Evidence Human hyper-inflammatory phase identify Immunomodulatory therapies Immunotherapy Inflammation Intervention low dose dexamethasone mechanism Microvascular thrombosis outcomes pandemic physician potential therapy proliferation recovery Repurposed drug repurposing review safety profile screened therapeutic therapy Trial vascular permeability Volume
[DOI] 10.3390/jcm9092935 PMC 바로가기 [Article Type] Review

Ivermectin: A Closer Look at a Potential Remedy

Internal Medicine

Published on 2020-09-112022-10-31
Journal: Cureus [Category] COVID-19,

Efficacy and safety of chloroquine and hydroxychloroquine in the treatment of patients with COVID-19 combined with diabetes mellitus A protocol for systematic review and meta-analysis

4900

Published on 2020-09-112022-10-30
Journal: Medicine [Category] COVID-19, SARS,

[키워드] adverse outcomes Adverse reactions Analysis Anti-inflammatory Antiviral blood glucose can be used CBM Chinese Chloroquine Clinical improvement clinical trial CNKI Cochrane Library conducted country COVID-19 COVID-19 patient Data analysis database death diabete diabetes Diabetes Mellitus effective Effectiveness English Evidence fasting blood fasting insulin Glucose glycosylated HCQ hemoglobin Hospitalization Hydroxychloroquine ICU improvement include independent risk factor Infectious disease Lung imaging mechanical ventilation Meta-analysis metabolic disease mortality rate patients with COVID-19 peer-reviewed Primary outcome protocol Randomized controlled trials Registration review shown Symptom systematic review Treatment VIP virus nucleic acid Web of Science with COVID-19
[DOI] 10.1097/MD.0000000000022031 PMC 바로가기 [Article Type] 4900

It is unprecedented: trial management during the COVID-19 pandemic and beyond

Commentary

Published on 2020-09-112022-10-29
Journal: Trials [Category] Coronavirus, SARS,

A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction

텐서 분해 기반 비지도 특징 추출을 통한 신종 코로나바이러스(SARS-CoV-2)에 대한 새로운 첨단 in silico 약물 발견 방법

Research Article

Published on 2020-09-112022-08-13
Journal: PLoS ONE [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected alvocidib antiviral drug applied atorvastatin candidate canertinib cell line chloride clinical trial clinical trials Community Compound coronavirus costly COVID-19 Critical develop dibromochloromethane doxycycline drug drug candidate Drug discovery effective effective drug effective drugs experimental validation expression fluticasone gadolinium geldanamycin gene expression profile Gene expression profiles gentamicin identify in silico Ivermectin lung cancer meloxicam mitoxantrone motexafin gadolinium Novel coronavirus Numerous pandemic patients with COVID-19 quercetin radicicol respiratory SARS-CoV-2 Screen screened selected severe acute respiratory syndrome Coronavirus significantly sorafenib Tensor time-consuming treating COVID-19 trovafloxacin
[DOI] 10.1371/journal.pone.0238907 PMC 바로가기 [Article Type] Research Article

Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis

미국의 COVID-19 성인 31,461명의 사망률과 관련된 동반 질환: 연합 전자 의료 기록 분석

Research Article

Published on 2020-09-102022-08-13
Journal: PLoS Medicine [Category] COVID-19, Medicine and Health Sciences, SARS,

[키워드] 95% CI 95% confidence interval African American age analyses Analysis Asian association Bame Characteristics Charlson Comorbidity Index chronic pulmonary disease clinical trial clinical trials coded collected Comorbidities Comorbidity condition conducted congestive heart failure coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients data entry database death Dementia determine develop diabetes Diabetes Mellitus disease Electronic health records electronic medical record electronic medical records Ethnicity Evidence example Factor female group groups health condition healthcare help higher odd higher odds hospital Hypothesis identify identifying include interquartile range Intervention likelihood limitation Liver disease Logistic regression male Male sex median age medical record medical records Mild Mortality multivariate Myocardial infarction network Odds ratio Older Older age organization outbreak participant Participants Patient patients people with COVID-19 previous study provided public health emergency remained renal renal disease reported Research researcher Result retrospective cohort study risk of death Sex significantly solid tumor Stephanie stratified study period suggested the United State Tumor United States white with COVID-19
[DOI] 10.1371/journal.pmed.1003321 PMC 바로가기 [Article Type] Research Article

Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2

Observation

Published on 2020-09-102022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 mRNA ACE2 protein activity acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral antiviral action antiviral activity antiviral drug antiviral gene approved benefit bronchial epithelial cells canonical Cell cell line clinical trial clinically coronavirus coronavirus disease counterbalance COVID-19 COVID-19 therapeutics Critical cytokine deaths dose-dependent manner Ebola virus Effect effector elevated ENhance entry receptor exacerbate exhibited expression help hepatitis C virus highlight HIV Host human lung I, II IFN IFN treatment IFN-β IFN-γ IFN-λ IFN-λ1 IFNs immune Immunotherapy Infection inhibited Innate immune defense interferon interferons investigated ISG ISG response ISGs limit mechanism mRNA pandemic produced raising receptor receptors repurposing Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 replication Severe infection Side effects surface protein the SARS-CoV-2 therapy Threats transcript treat Type type I upregulated upregulating virus entry virus replication viruses
[DOI] 10.1128/mBio.01928-20 PMC 바로가기 [Article Type] Observation