Experiences of early graduate medical students working in New York hospitals during the COVID-19 pandemic: a mixed methods studyObservational Study Published on 2021-02-182022-10-04 Journal: BMC Medical Education [Category] MERS, 임상, [키워드] analyzed benefit Care chose coded conducted Contact coronavirus disease COVID-19 COVID-19 patients discharge Early graduation eligible experience Factor focus functions help hospital hospitalizations hospitals identify initial investigator medical students New York Observational cohort study pandemic participated Patient care patients physician professionals reported response Result supplementary material survey symptomatic infection transcribed transfer undergraduate medical education verbal with COVID-19 [DOI] 10.1186/s12909-021-02543-9 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targetsSARS-CoV-2 조기 감염 시그니처는 잠재적인 주요 감염 메커니즘 및 약물 표적 식별Research Article Published on 2021-02-182022-09-10 Journal: BMC Genomics [Category] MERS, 신약개발, 유전자 메커니즘, [키워드] addition antidepressants association atorvastatin BALF BALF cells bimodal biopsies Bronchoalveolar lavage fluid Bronchoalveolar lavage fluid cells candidate Candidates caused Cell characterized COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 outbreak COVID-19 treatments cultured cell cultured cells database dataset deaths Differential gene expression disease drug drug target early infection effective Efficacy expression profile Gene Expression gene signature HDAC healthy healthy and infected patients highlighting ibuprofen identify IFIT2 Immune cell immune cells infected patient infected with SARS-CoV-2 Infection infection mechanism inhibitors investigated ketoconazole lung lung biopsies mechanism moderate mononuclear cell mononuclear cells Mortality NFKBIA PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPP1R15A Previous studies previous study public health Result robust safety profile SARS-CoV-2 SARS-CoV-2 gene expression signature SARS-COV-2 infection Sequencing severely infected patient severely infected patients severity shown signature single-cell supplementary material the disease the SARS-CoV-2 therapy TNFAIP3 transcriptional activity treating SARS-CoV-2 infection Treatment Vaccine [DOI] 10.1186/s12864-021-07433-4 PMC 바로가기 [Article Type] Research Article
Emergency medical services evaluations for chest pain during first COVID-19 lockdown in Hollands-Midden, the NetherlandsOriginal Article Published on 2021-02-182022-10-30 Journal: Netherlands Heart Journal [Category] COVID-19, [키워드] 95% CI 95% confidence interval addition age Care chest pain cohorts COVID-19 decrease Effects emergency medical service evaluated Health incidence initial lockdown lockdowns male medical service Myocardial infarction Netherland objective OHCA Patient primary endpoint reduction reduction in remained Result risk STEMI supplementary material Symptom Transport were assessed [DOI] 10.1007/s12471-021-01545-y PMC 바로가기 [Article Type] Original Article
Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infectionsSARS-CoV-2 IgG 분석의 엄격한 임계값으로 인해 경증 감염이 제대로 감지되지 않음Research Article Published on 2021-02-182022-09-01 Journal: BMC Infectious Diseases [Category] MERS, 진단, 치료제, [키워드] 95%CI Abbott Adjusting Ageusia Analysis Anosmia Anosmia/ageusia antibodies antibody Architect best CMIA Cohort COVID-19 COVID-19 infection diagnostic ELISA epidemiological healthcare worker Healthcare workers hospitalised house IgG response IgG responses immunoassay immunoassays implication in-house ELISA individual Infection Interpretation less Loss of Smell loss of smell/taste Microparticle Mild mild infection mild SARS-CoV-2 infection Oxford patients PCR-confirmed positive positive result Probability probe probes proportion Quantitative reported Result risk factor Sample SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-COV-2 infection sensitivity Sensitivity and specificity serology specificity supplementary material symptomatic threshold thresholds under-detection while [DOI] 10.1186/s12879-021-05878-2 PMC 바로가기 [Article Type] Research Article
Development and validation of an online model to predict critical COVID-19 with immune-inflammatory parametersResearch Published on 2021-02-182022-10-30 Journal: Journal of Intensive Care [Category] COVID-19, [키워드] 95% CI 95% confidence interval Admission Algorithm applied AUC C reactive protein China Chinese clinical Cohort collected COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness dataset death decision defined develop development discharge disease dysfunction external validation facilitate feature Gradient high risk hospital identify Immune-inflammatory parameters Inflammatory Intensive intensive care interleukin 2 Intervention invasive ventilation lymphocyte machine learning Machine learning algorithms network Neural Occurrence Online model outcome parameter parameters Patient predict Predictive procalcitonin receiving receptor Registered registry Regression reported Result Selection severity Shrinkage supplementary material support vector machine SVM training dataset tree validation cohort [DOI] 10.1186/s40560-021-00531-1 PMC 바로가기 [Article Type] Research
SARS-CoV-2 RNA in plasma samples of COVID-19 affected individuals: a cross-sectional proof-of-concept studyCOVID-19 영향을 받는 개인의 혈장 샘플에서 SARS-CoV-2 RNA: 횡단면 개념 증명 연구Research Article Published on 2021-02-172022-09-01 Journal: BMC Infectious Diseases [Category] MERS, 진단, [키워드] affected Blood characterized COVID-19 cross-sectional ddPCR develop Fisher exact test haematologic haematological malignancies haematological malignancy help Hematological malignancies higher risk hospital Hospitalized individual IQR laboratory data management median Molecular diagnosis mortality rate outcome Patient patients with COVID-19 plasma plasma sample predict Prognosis quantified Quantitative recent respiratory respiratory sample Respiratory samples Result SARS-CoV-2 SARS-CoV-2 RNA severe COVID-19 significant difference significant differences supplementary material Support variables Viral Viral load Viremia were used Wilcoxon test [DOI] 10.1186/s12879-021-05886-2 PMC 바로가기 [Article Type] Research Article
Evaluating the effect of infographics on public recall, sentiment and willingness to use face masks during the COVID-19 pandemic: a randomised internet-based questionnaire studyRandomized Controlled Trial Published on 2021-02-172022-10-04 Journal: BMC Public Health [Category] MERS, 임상, [키워드] Adult patient Anxiety Audiovisual aids average cognitive Cohort Compliance Control COVID-19 demonstrated European evaluate the effect Evaluating Face mask Face masks Factors FIVE greater group Guidance Health Behavior highest highlighting information insight International knowledge Mask Masks Ministry of Health outcome Personal protective equipment Prevalence Primary outcome public health questionnaire randomised recall recruited reduce reduced reducing respondent Result secondary significantly higher socio-demographic supplementary material team the WHO Transmission UK Government Variation wear face mask WHO World Health Organisation [DOI] 10.1186/s12889-021-10356-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effects of subjective successful aging on emotional and coping responses to the COVID-19 pandemicResearch Article Published on 2021-02-172022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, MERS, [키워드] age aging Chinese coronavirus disease COVID-19 pandemic COVID-19 virus development Effect emotional Emotional and coping responses finding Hong Kong Hospitalization mechanism Mediation analysis Mortality negative emotion Older pandemic participated Perceived time limitation platform positive questionnaire recruited reported response responses Result Subjective perceptions of successful aging supplementary material were measured [DOI] 10.1186/s12877-021-02076-2 PMC 바로가기 [Article Type] Research Article
CT-based radiomics combined with signs: a valuable tool to help radiologist discriminate COVID-19 and influenza pneumoniaCT 기반 방사선과 징후 결합: 방사선 전문의가 COVID-19와 인플루엔자 폐렴을 구별하는 데 도움이 되는 유용한 도구Original Research Published on 2021-02-172022-09-01 Journal: BMC Medical Imaging [Category] Fulltext, MERS, 진단, [키워드] Accuracy Analysis AUC bootstrap build characteristic Chest CT image collected Computed tomography Coronavirus disease 2019 COVID-19 COVID-19 pandemic CT sign CT signs dataset demonstrated differential diagnosis feature Features help independent Influenza influenza pneumonia initial Patient Pneumonia Predictive Radiomics receiver operating characteristic Result ROC ROC Curve selected sensitivity specificity supplementary material Viral Viral pneumonia X-ray computed tomography [DOI] 10.1186/s12880-021-00564-w PMC 바로가기 [Article Type] Original Research
Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO studyObservational Study Published on 2021-02-172022-10-04 Journal: Diabetologia [Category] MERS, SARS, 임상, [키워드] 95% CI Abstract Admission Admission plasma glucose age Anticoagulant Aspartate aminotransferase C-reactive protein clinician Complication complications coronavirus COVID-19 death Deleterious diabetes Diabetic died discharge discharged Dyspnoea Factor Factors Follow-up French HbA1c help history Home discharge hospital Hospital admission hospital discharge Hospital stay hospitalised insulin mechanical ventilation median Median BMI men Mortality multicentre Multivariable models outcome pandemic participant Participants Patient patients with diabete peer-reviewed Prognostic factor reduced Result SARS-CoV-2 screened supplementary material symptom duration therapy Treatment white cell [DOI] 10.1007/s00125-020-05351-w PMC 바로가기 [Article Type] Observational Study