Challenges and Strategies for Pakistan in the Third Wave of COVID-19: A Mini ReviewPublic Health Published on 2021-08-132022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] accelerate acquisition attack average challenge coronavirus 2 country COVID-19 COVID-19 pandemic death Delay disease Human lockdown MINI Novel coronavirus outbreak pandemic per day recorded respiratory Respiratory system review SARS-CoV-2 Strategy target turn vaccination Vaccine virus Virus Disease Wave [DOI] 10.3389/fpubh.2021.690820 PMC 바로가기 [Article Type] Public Health
A cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)SARS-COV-2의 전염 감소를위한 인터페론 ß-1A의 군집 무작위 시험 : 포함 된 코로나 바이러스 질병 19 시험 (Concord-19)에 대한 프로토콜.Study Protocol Published on 2021-08-132022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 임상, 치료제, [키워드] accelerate administration All participant All participants Asymptomatic Cluster community transmission Contact Containing coronavirus coronavirus disease COVID COVID-19 COVID-19 case COVID-19 cases COVID-19 diagnosis determine Disease progression dose Effectiveness Hospitalization hospitalizations identify IFN IFN treatment incidence include index case index cases infected case infected cases Infection interferon Interrupting Mild Moderate COVID-19 Population Prevent prevention proportion protocol randomization Randomized randomized trial receive reduce reduction Registered Registration SARS-CoV-2 SARS-COV-2 infection Secondary objective Secondary objectives shedding Spread Standard of care subcutaneous administration therapy Transmission transmission of SARS-CoV-2 Treatment Trial Trial registration Viral viral clearance [DOI] 10.1186/s12879-021-06519-4 PMC 바로가기 [Article Type] Study Protocol
Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project생애 동안 만성 외상성 뇌병증을 탐지하고 진단하는 방법 개발 : 진단 CTE 연구 프로젝트를위한 이론적 근거, 설계 및 방법론Multicenter Study Published on 2021-08-122022-09-10 Journal: Alzheimer's Research & Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] accelerate age anonymized data baseline biological sample biological samples Biomarker Biomarkers Blood blood draw Brain can not chronic Chronic traumatic encephalopathy Clinical research cognitive Cognitive function College football Community Concussion Consensus Contact COVID-19 pandemic detect develop Developing diagnose diagnosed Diagnosis diagnostic Diagnostic Criteria disease Donor Encephalopathy Enrollment Epidemiology evaluated examined facilitate finding Follow-up Football Genetic Head trauma imaging impacts in vivo life Lumbar puncture magnetic resonance imaging male participants Measures mechanisms methodology MRI MRS multicenter National Football League network neurodegenerative Neurodegenerative disease Neuroimaging neurologic neurological Neurological disorders Neuropsychiatric objective organized participant Participation positron emission Positron emission tomography reliability Remote assessment Repetitive head impacts Research Research diagnostic criteria resource Result risk Risk factors Saliva Sample size self-report measure Spectroscopy Subconcussion supplementary material syndrome Tau TES trauma Traumatic brain injury Traumatic encephalopathy syndrome Treatment Validity [DOI] 10.1186/s13195-021-00872-x PMC 바로가기 [Article Type] Multicenter Study
National control laboratory independent lot testing of COVID-19 vaccines: the UK experiencePerspective Published on 2021-08-122022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] accelerate approach approval Biological clinical trial clinical trials Combination Control COVID-19 COVID-19 pandemic Critical effort independent Laboratory measure Medicine MHRA NIBSC pandemic provide public health Regulation Regulatory Research Stage Standard Vaccine vaccine availability Vaccine development viral infection [DOI] 10.1038/s41541-021-00368-7 PMC 바로가기 [Article Type] Perspective
Estimating global and regional disruptions to routine childhood vaccine coverage during the COVID-19 pandemic in 2020: a modelling study2020년 코로나19 팬데믹 기간 동안 정기적인 아동 백신 접종에 대한 전 세계 및 지역적 혼란 추정: 모델링 연구Articles Published on 2021-08-072022-10-30 Journal: Lancet (London, England) [Category] COVID-19, Fulltext, MERS, 백일해, 파상풍, [키워드] absence accelerate affected Analysis approach Asia burden childhood children Combination Coverage COVID-19 COVID-19 pandemic disease dose doses effort eligible estimate expected finding foundation funding Health Service Hierarchical highest Impact Latin America lowest Melinda Gate Middle East Oceania Outbreaks pandemic random reduce reduction reductions in regions Release remained representing resource risk routine SARS-CoV-2 transmission sub-Saharan Africa trajectory vaccination Vaccine vaccine dose widespread [DOI] 10.1016/S0140-6736(21)01337-4 PMC 바로가기 [Article Type] Articles
Real-time SARS-CoV-2 diagnostic and variants tracking over multiple candidates using nanopore DNA sequencing나노 포어 DNA 시퀀싱을 사용하여 여러 후보자보다 실시간 SARS-COV-2 진단 및 변이체 추적Article Published on 2021-08-052022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] accelerate accelerated acute respiratory syndrome B.1.1.7 candidate Candidates Cell described diagnostic diagnostics DNA DNA sequencing expected focus gene encoding Genome assembly algorithms host receptor implementation involved Mutation Nanopore Novel coronavirus Occurrence pandemic progression proof of concept Protein respiratory responsible SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Sequencing Severe acute respiratory syndrome spike gene Spike protein Surveillance the cell the Spike use variant variants Viral viral genome [DOI] 10.1038/s41598-021-95563-w PMC 바로가기 [Article Type] Article
Case Report: Remdesivir and Convalescent Plasma in a Newly Acute B Lymphoblastic Leukemia Diagnosis With Concomitant Sars-CoV-2 InfectionPediatrics Published on 2021-08-022022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] accelerate Acute lymphoblastic leukemia adverse event age antiviral therapy Blood Bone marrow Cancer Chest clinical conditions Concomitant convalescent plasma COVID-19 diagnosed Diagnosis disease female Fever Hypothesis Immunosuppressive treatment Infection infections leukemia malignancies management moderate molecular analysis Morphological neutropenia oncology patients Patient pediatric Prognosis pulmonary involvement Remdesevir required risk SARS-CoV-2 detection SARS-COV-2 infection SARS–CoV−2 severe SARS-CoV-2 Spread stability therapy Treatment worsened [DOI] 10.3389/fped.2021.712603 PMC 바로가기 [Article Type] Pediatrics
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammationSARS-CoV-2 N 단백질은 NLRP3 inflammasome 활성화를 촉진하여 과염증을 유도합니다Article Published on 2021-08-022022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 치료법, [키워드] accelerate activated Activation Acute inflammation aggravate ASC binding blocked caspase-1 COVID-19 COVID-19 severity cultured cell cultured cells cytokine cytokine production Cytokine storm Cytokines death facilitate hyperinflammation IL-1β IL-6 induce Infection Inflammasome inflammasomes Inflammatory response Inflammatory responses inhibitor interact Interaction Lung injury maturation mechanism mice Mouse models N protein NLRP3 NLRP3 inflammasome NLRP3 inflammasome assembly Proinflammatory cytokine proinflammatory cytokines Proinflammatory response promote Protein resulting reveal SARS-COV-2 infection SARS-CoV-2 N protein Sepsis severe symptom severe symptoms severity shown specific inhibitor Viral Viral host response with COVID-19 [DOI] 10.1038/s41467-021-25015-6 PMC 바로가기 [Article Type] Article
Comparison of Medication Prescribing Before and After the COVID-19 Pandemic Among Nursing Home Residents in Ontario, CanadaObservational Study Published on 2021-08-022022-10-04 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] absolute difference accelerate ACE ACE inhibitors adverse effect Affect Analysis angiotensin receptor blocker Angiotensin-converting enzyme Antibiotics ARBs association average base Canada Care change changes in Cohort cohorts consequence Course COVID-19 COVID-19 pandemic Effect exposure finding function Health home Importance increases in inhibitors initial Intervention measure medication medications MONITOR Nursing objective observation observation period Older Onset outcomes pandemic parameter participant Point population-based cohort prescribing prescription medication professional proportion ranged Relevance resident Result selected setting significant increases in significant level standard error statistically significant tested Uncertainty use of antibiotics Weekly [DOI] 10.1001/jamanetworkopen.2021.18441 PMC 바로가기 [Article Type] Observational Study
A novel nano therapeutic using convalescent plasma derived exosomal (CP Exo) for COVID-19: A combined hyperactive immune modulation and diagnosticsCOVID-19에 대한 회복기 혈장 유래 엑소좀(CP Exo)을 사용한 새로운 나노 치료제: 과민성 면역 조절 및 진단 결합Article Published on 2021-08-012022-09-12 Journal: Chemico-biological interactions [Category] MERS, SARS, 바이오마커, 신약개발, 진단, 치료제, [키워드] accelerate acting activated Adequate antibodies antibody Antigen Biomarker Cell convalescent plasma COVID COVID-19 COVID-19 patients derivative Diagnosis diagnostic diagnostics DNA drug drug delivery Effect effective Efficacy Epigenetic Exosome Exosomes genetic material highlight Hypothesis immune immune modulation immune response Immunotherapy in vivo inhibitory lipids miRNAs molecular pathogen persistence plasma Proteins recognizing responsible RNA RNAs Sensitivity and specificity shown target pathogen therapeutic Treatment treatment strategy Vesicle [DOI] 10.1016/j.cbi.2021.109497 PMC 바로가기 [Article Type] Article