Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternativesShort communication Published on 2021-05-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] 진단, 치료기술, [키워드] 95% CI acute COVID-19 alleviate Antigen antigenaemia approach Blood blood draw Cohort collected COVID COVID-19 COVID-19 diagnosis detection diagnostic diagnostics eight ELISA FIVE France French limit Lower respiratory tract marker molecular assays N-antigen nasopharyngeal Nasopharyngeal samples Nasopharyngeal swab nasopharyngeal viral objective Patient patients performance plasma positive positive RT-PCR provide reagents resource Result robust RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N-antigen SARS-CoV-2 nucleocapsid sensitivity serum serum sample specificity symptom onset symptoms onset tested [DOI] 10.1016/j.cmi.2020.11.025 [Article Type] Short communication
Use of a Telemedicine Risk Assessment Tool to Predict the Risk of Hospitalization of 496 Outpatients With COVID-19: Retrospective AnalysisOriginal Paper Published on 2021-04-302022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, [키워드] 95% CI acute COVID-19 adjusted hazard ratio age Analysis analyzed applied assessment assigned Atlanta benefit Care Community conducted covariates COVID-19 Cox regression Cox regression model described determine Endpoint Enrollment Factor Final Gender Health Health care worker high risk Hospitalization hospitalizations nonhospitalized numbers of patients obesity objective Older outcomes Outpatient Patient Patient care Population predict public health reported resource Result Retrospective study risk Risk assessment SARS-CoV-2 survival Telemedicine were assessed with COVID-19 [DOI] 10.2196/25075 PMC 바로가기 [Article Type] Original Paper
Krebs von den Lungen 6 (KL-6) as a marker for disease severity and persistent radiological abnormalities following COVID-19 infection at 12 weeksKrebs von den Lungen 6(KL-6)은 12주에 COVID-19 감염 후 질병 중증도 및 지속적인 방사선 이상에 대한 마커입니다.Observational Study Published on 2021-04-292022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, 임상, [키워드] abnormal CT scans abnormality absence acute COVID-19 acute infection acute respiratory distress acute respiratory distress syndrome Admission age ARDS association Asymptomatic baseline breathlessness cell injury clinical manifestation clinical manifestations Clinical severity Cohort Complication convalescent correlation COVID-19 infection CT scan CXR deconditioning determine disease severity Dyspnoea epithelial cell fibrosis finding Follow up appointment glycoprotein help hospital include Infection initial Injury Lung fibrosis male marker median medium mucin no significant difference observational study on admission oxygen Patient patients persistence presence or absence proportion Prospective pulmonary epithelial cell radiological abnormalities radiological abnormality Research question respiratory distress Respiratory distress syndrome Result severity significant difference significantly higher syndrome with COVID-19 [DOI] 10.1371/journal.pone.0249607 PMC 바로가기 [Article Type] Observational Study
Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—A Systemic Review and Comparison of Clinical Presentation and SymptomatologyReview Published on 2021-04-262022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] acute COVID-19 advancement Analysis chronic fatigue syndrome clinical conditions conducted COVID COVID-19 fatigue IMPROVE Long Long-haul COVID-19 management material ME/CFS methodology myalgic encephalomyelitis overlap Patient presentation reported reported symptom Research review selected similarity Standardization Symptom Symptomatology syndrome systemic Systemic review Treatment [DOI] 10.3390/medicina57050418 PMC 바로가기 [Article Type] Review
Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 InfectionCase Report Published on 2021-04-232022-10-31 Journal: Case Reports in Neurological Medicine [Category] COVID-19, [키워드] abnormality acute COVID-19 acute phase Affect African American baseline Brain Central nervous system Clinical course clinical recovery COVID-19 COVID-19 hospitalization demonstrated described discharged home Encephalopathy Endothelial cell female FLAIR hospital Hospitalization Infection MRI multiple comorbidity Neuroinflammation Neuroinvasive Neurological disorder neurological manifestations numerous organs observational study Patient Posterior readmission returned Reversible SARS-CoV-2 SARS-COV-2 infection Seizure Severe COVID-19 Infection supported supportive care syndrome Treatment [DOI] 10.1155/2021/5564802 PMC 바로가기 [Article Type] Case Report
High-dimensional characterization of post-acute sequelae of COVID-19 Research Published on 2021-04-222022-10-05 Journal: Nature [Category] SARS, 치료법, [키워드] acute COVID-19 acute phase Affair Analysis approach Cardiovascular disorders Care clinical manifestation COVID-19 database death Department described diagnoses Diagnosis disease disorders Evidence fatigue Health health system healthcare help higher risk Hospitalized identify include increase individuals with COVID-19 Infection intensive care Laboratory laboratory abnormality malaise medication mental health disorders Metabolic disorders Musculoskeletal National nervous system organ system organ systems Pain Patient patients with COVID-19 people with COVID-19 prespecified outcome reduce resources Respiratory system reveal risk severity survived therapeutic veteran [DOI] 10.1038/s41586-021-03553-9 [Article Type] Research
Assessment of S1-, S2-, and NCP-Specific IgM, IgA, and IgG Antibody Kinetics in Acute SARS-CoV-2 Infection by a Microarray and Twelve Other Immunoassays마이크로어레이 및 12개의 기타 면역분석을 통한 급성 SARS-CoV-2 감염에서 S1, S2 및 NCP 특이적 IgM, IgA 및 IgG 항체 동역학 평가Comparative Study Published on 2021-04-202022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute SARS-CoV-2 infection analyzed antibodies antibody antibody kinetics Antigen assessment blood sample Blood samples commercial immunoassay coronavirus coronavirus disease Coronavirus disease 2019 declined detection rate ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays hospitalized patient hospitalized patients IgA IgA levels IgG IgG antibodies IgG antibody IgG response IgG responses IgM immunoassay immunoassays Immunoglobulin immunoglobulins Infection Kinetics Lower respiratory tract Microarray nucleocapsid protein occur Other Patient patients Pneumonia post-symptom onset progressed quantified Rapid test reached respiratory SARS SARS-CoV-2 sensitivities sensitivity Seven severely ill patients specific IgM Specificities specificity the microarray total Ig tracheal Viral Viral concentration viral concentrations [DOI] 10.1128/JCM.02890-20 PMC 바로가기 [Article Type] Comparative Study
Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects회복된 COVID-19 피험자에서 항 SARS-CoV-2 항체의 특성Article Published on 2021-04-162022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD Anti-RBD IgG anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 immunoglobulin antibody Antibody Response caused Chain Reaction characterized coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection cycle threshold determine determined by diagnose domain elicit ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay global pandemic highlight humoral immune response Immunity Immunoglobulin individual Infection mild infection neutralize live SARS-CoV-2 polymerase chain polymerase chain reaction post-symptom onset Protein raise RBD RBD IgG titers Receptor-binding domain recovered resolved respiratory reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 virus Serological assay serological assays serological survey Serological surveys serology subject subjects symptom onset Viral viral neutralization virus while [DOI] 10.3390/v13040697 PMC 바로가기 [Article Type] Article
Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection새로운 ELISA 프로토콜은 기존 SARS-CoV-2 반응성 항체를 풍토성 코로나바이러스 면역 및 연령과 연결하고 다중 매개변수 감지를 통해 급성 COVID-19의 향상된 혈청학적 식별을 나타냅니다.Immunology Published on 2021-04-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Abbott Abbott test acute COVID-19 added age antibodies antibody Antibody detection antibody levels approved assays binding domain buffer circulating coated coronavirus COVID-19 COVID-19 pandemic detection Dilution disease disease status Economy ELISA ELISA protocol Endemic EUA HIV Hospitalized identification IgA IgA antibodies IgA antibody IgA level IgA levels IgG IgM Immunity immunoassay impacted implication Improved infected individuals information life magnitude measurement Microparticle novel nuance nuances nucleocapsid (N) nucleocapsid protein optical densities optical density platform pre-existing immunity RBD reactive reagents receptor binding domain (RBD) reported SARS-CoV-2 SARS-CoV-2 IgM SARS-CoV-2 infected individual SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody sensitive serologic serology serology test significantly lower SLE specific IgM standard curve Strains subject subjects Symptoms utility Viral protein Viral proteins virus transmission [DOI] 10.3389/fimmu.2021.614676 PMC 바로가기 [Article Type] Immunology
High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19높은 처리량, 단일 사본 시퀀싱은 급성 COVID-19 동안 체액 면역 증가와 일치하는 SARS-CoV-2 스파이크 변이체를 보여줍니다Clinical Trial Published on 2021-04-082022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 Analysis Antibody binding Antiviral antiviral drug antiviral therapies antiviral therapy applied approach arising autologous antibodies binding Cell culture clearance Clinical outcome Clustering contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 cross-sectional analysis detect detectable domain epitope evade Evolution exhibit Frame furin furin cleavage site Genetic genetic diversity Genome genomic RNA Haplotype help Humoral immunity immune response immune responses Immune-mediated in vitro in vivo increase in independent individual individuals with COVID-19 infected individual infected individuals infecting initial intra-individual longitudinal analysis Mutation mutations Non-synonymous mutation NTD one individual participant Pathogenesis predominant regions respiratory reveal SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 replication SARS-CoV-2 spike protein SARS-CoV-2 spike variant SARS-CoV-2 variant SARS-CoV-2 variants selected selection of variant sequence Sequencing sequencing technology serum serum sample Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein study participant surface protein surface proteins susceptibility the SARS-CoV-2 Time frame upper respiratory sample variant variants Variation virion virus virus RNA virus variants viruses WA-1 reference with COVID-19 [DOI] 10.1371/journal.ppat.1009431 PMC 바로가기 [Article Type] Clinical Trial