Mathematical model of the feedback between global supply chain disruption and COVID-19 dynamicsArticle Published on 2021-07-292022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] activities alleviate Care Containment strategy COVID-19 Critical Disease network Effect exacerbated Government Health Health care economics highlight Infection Infectious disease Infectious diseases information technology Interaction mathematical mathematical model North America outbreak pandemic pandemic of COVID-19 Pandemics provide reduce resource SARS-CoV-2 Scientific data spatiotemporal Spread the disease threat Travel viral infection [DOI] 10.1038/s41598-021-94619-1 PMC 바로가기 [Article Type] Article
Natural products provide a new perspective for anti-complement treatment of severe COVID-19: a reviewReview Published on 2021-07-282022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] accounted Activation alleviate Anti-complement therapy Chinese chronic inflammation Coagulopathy complement Complement inhibitor contribute COVID-19 Critically ill Critically ill patient Cytokine storm drug resistance Efficacy Efficiency etiological hotspot immune response intravascular coagulation Mortality multiple organ failure natural natural products New organ dysfunction Perspective progressive respiratory failure reduction Regulation severity of COVID-19 Side effect supplementary material Symptom therapy Toxicity Treatment uncontrolled upstream with COVID-19 [DOI] 10.1186/s13020-021-00478-3 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine DevelopmentMolecular Biosciences Published on 2021-07-282022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome affecting alleviate antibody antigenic target antiviral therapeutics approach can be used cell lines clinical development conserved Coronaviral coronavirus coronavirus disease Coronavirus pandemic Coronavirus-2 COVID COVID-19 COVID-19 pandemic cross-react demonstrated detect development Diagnosis diagnosis of COVID-19 diagnostic diagnostics domain effective ELISA extrapolation facilitate host cell receptor Human IgM and IgG in vitro study Infection inhibiting interact Lateral flow immunoassays mAb mAbs molecular monoclonal antibody Mortality N-terminal domain neutralize Neutralizing neutralizing antibody pandemic platform polyclonal antibody Prevent Prophylaxis RBD Receptor binding domain Region researcher S-protein S1 and S2 S1 domain S2 domain SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection selection pressure sequence similarity Serological assay spike spike gene spike glycoprotein the RBD Treatment trimer Vaccine Vaccines Viral protein virus virus-cell membrane fusion [DOI] 10.3389/fmolb.2021.607886 PMC 바로가기 [Article Type] Molecular Biosciences
Effect of EAP Psychological Intervention on Improving the Mental Health of Medical Workers Under the Novel Coronavirus Epidemic in ChinaPublic Health Published on 2021-07-282022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] adopted alleviate analyzed Anxiety assessments assistance Campus change checklist children China conducted coronavirus epidemic correlated Depression EAP psychological intervention East Effect employee employee assistance program Epidemic evaluate form Gender group Guidance Healthcare professional healthcare professionals higher risk hospital Hospital staff Implications Improving indicated initial Intervention Logistic regression analysis measure Measures Medical workers men mental health multivariate no significant difference novel Novel coronavirus participated positive result Program proportion protective factor Psychological psychological changes Psychological intervention psychological pressure Psychological problems psychological symptom psychological symptoms recruited reduce reduced reducing SCL-90 psychological evaluation sensitivity Shanghai significantly total score women worker [DOI] 10.3389/fpubh.2021.649157 PMC 바로가기 [Article Type] Public Health
Chronic and rare disease patients’ access to healthcare services during a health crisis: The example of the COVID‐19 pandemic in TurkeyOriginal Article Published on 2021-07-262022-11-01 Journal: Health Expectations : An International Journal of Public Participation in Health Care and Health Policy [Category] COVID-19, MERS, SARS, [키워드] access alleviate Analysis Anxiety approach caused chronic clinical information complex conducted coronavirus disease Coverage COVID‐19 COVID‐19 patients COVID‐19 decision‐making processe exacerbating example facilitate Factor Health healthcare access Healthcare provision healthcare service hospital IMPROVE Inclusion institution introduced İstanbul lack measure objective pandemic participated Patient Patient experiences patient organisations patients physical Physicians positive problem problems Public Qualitative rare disease rare diseases reduce Regulation response Result security Treatment Turkey [DOI] 10.1111/hex.13321 PMC 바로가기 [Article Type] Original Article
L-Leucine Promotes STAT1 and ISGs Expression in TGEV-Infected IPEC-J2 Cells via mTOR ActivationImmunology Published on 2021-07-222022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] activate activating Activation alleviate Amino acid blocked CCK-8 assay cell proliferation cells characterized demonstrated downregulation downstream effective ELISA epithelial cell evidenced expression flow cytometry gastroenteritis Impact increase in Infection intestinal IPEC-J2 cells ISG L-leucine mammalian target of rapamycin mechanism mTOR signaling pathway PCNA PKR Prevent promoted reduced reduction Replication reversed signal transducer and activator of transcription 1 Stat1 TGEV transmissible gastroenteritis virus virus virus infection western blot Western blot analysis [DOI] 10.3389/fimmu.2021.656573 PMC 바로가기 [Article Type] Immunology
Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19네트워크 기반의 재구성은 항-알라민을 COVID-19에서 심각한 폐 염증을 조절하기위한 약물 후보로 식별합니다.Research Article Published on 2021-07-222022-09-10 Journal: PLoS ONE [Category] 신약개발, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome airway alarmin alarmins alleviate Analysis approach C5a Consequences COVID-19 cytokine Cytokine release syndrome Cytokine storm Dexamethasone drug drug candidate endothelial cells epithelial Estrogen Estrogens Evolution Health Health services identify IL17 IL1β IL23 IL33 IL6 immune dysregulation Immunity inception incidence Inflammation inhibitor inhibitors JAK2 less Lung inflammation Other respiratory viruses Predictive Prevent progression Protein RAGE receiving receptor receptors reducing respiratory respiratory distress Respiratory distress syndrome respiratory viruses SARS-CoV-2 SARS-CoV-2 vaccines severe COVID-19 severe lung inflammation ST2 Support syndrome target targets the cytokine storm therapeutic therapeutic drug These data TNFα transition Treatment TSLP while [DOI] 10.1371/journal.pone.0254374 PMC 바로가기 [Article Type] Research Article
Antiviral Effect of Budesonide against SARS-CoV-2SARS-COV-2에 대한 Budesonide의 항 바이러스 효과Communication Published on 2021-07-202022-09-10 Journal: Viruses [Category] SARS, 변종, 치료제, [키워드] (alpha (Beta) administration alleviate Alpha antiviral activity antiviral drug antiviral drugs antivirals B.1.1.7 B.1.351 Budesonide caused Cell cell viability circulating variant comparable contribute coronavirus coronavirus 2 Corticosteroids COVID-19 COVID-19 symptom COVID-19 symptoms disease dose-dependent inhibition Effect glucocorticoid Glucocorticoids Infection Mild previous study recovery times reduce reduced reported respiratory respiratory viruses SARS-CoV-2 SARS-CoV-2 replication tested treatment for COVID-19 variants of concern viability Viral viral variant VoC [DOI] 10.3390/v13071411 PMC 바로가기 [Article Type] Communication
Nanotechnology Integration for SARS-CoV-2 Diagnosis and Treatment: An Approach to Preventing PandemicReview Published on 2021-07-162022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] Adverse drug reactions alleviate antiviral medication antivirals approach biosensors boost caused coronavirus COVID-19 COVID-19 disease COVID-19 treatments Diagnosis died effective Efficacy Health health emergency inhibitors integration lack medications monoclonal antibodies Nanotechnology outbreak outcome pandemic Pathogenesis plasma Preventing protease inhibitors rapid immune response sanitizers SARS-CoV-2 Spread Symptom tested Therapies therapy Treatment treatment for COVID-19 vaccination Vaccine Vaccines virus World Health Organization [DOI] 10.3390/nano11071841 PMC 바로가기 [Article Type] Review
Family Cohesion and Stress Consequences Among Chinese College Students During COVID-19 Pandemic: A Moderated Mediation ModelPublic Health Published on 2021-07-152022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] Affect affective affective empathy age aggravate alleviate association Chinese Chinese college students cognitive empathy cohesion college consequence Consequences COVID-19 COVID-19 epidemic Factor family family cohesion fear Fear of COVID-19 help implication indicated individual internal and external large sample mechanism mediation mediation model mental health Model participant participated Prevent provide reported Result Spread Stress stress consequences student virus [DOI] 10.3389/fpubh.2021.703899 PMC 바로가기 [Article Type] Public Health