[Are SARS-CoV-2 reactive T cells detectable and potentially protective in patients under anti-CD20 treatment with an impaired humoral response?][SARS-CoV-2 반응성 T 세포는 체액성 반응이 손상된 항-CD20 치료를 받는 환자에서 감지 가능하고 잠재적으로 보호 가능한가요?]Article Published on 2021-11-012022-09-11 Journal: Zeitschrift Fur Rheumatologie [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-CD20 treatment antibody formation B cell cellular Cellular and humoral immunity Cellular immune response changed chronic inflammatory disease chronic inflammatory diseases Contact coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 depleting detectable effective English fatality framework Gut humoral Humoral immunity immune system Immunosuppression Infection Inflammatory diseases less life Masks monoclonal antibody obligatory organ Organ transplant pandemic pathogen Patient patients treated Probability Protective reactive recent Rheumatic diseases risk rituximab RTX SARS-CoV-2 SARS-CoV‑2 SARS-CoV‑2 vaccination. severe acute respiratory syndrome Coronavirus severity Spread T cell vaccination Vaccinations virus Welt [DOI] 10.1007/s00393-021-01083-3 PMC 바로가기 [Article Type] Article
Scientific rationale for developing potent RBD-based vaccines targeting COVID-19Review Article Published on 2021-10-282022-10-04 Journal: NPJ Vaccines [Category] 변종, 비임상, 임상, [키워드] addition Biological sciences Biomarker Cellular immune response COVID-19 cross-protective determinants domain dose full-length humoral immune response Infectious diseases natural infection neutralizing antibody non-inferiority offer pandemic PROTECT Protein RBD S-protein Safe SARS-CoV-2 spike the RBD vaccination Vaccine vaccine immunogen Vaccines variants of concern viral variant [DOI] 10.1038/s41541-021-00393-6 PMC 바로가기 [Article Type] Review Article
Effect of Age on Innate and Adaptive Immunity in Hospitalized COVID-19 PatientsArticle Published on 2021-10-192022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Activation adaptive age CD8 T cell cellular Cellular immune response cellular response clinical recovery coronavirus disease COVID-19 DCs deficiency dendritic cells Disease progression Effect effective higher risk hospitalized COVID-19 patients immunological mechanism Inflammation inflammatory immune response Innate innate immune investigated limit Monocytes Natural killer cells NK cells outcome Patient proinflammatory SARS-CoV-2 severity significantly higher subsequent Symptom symptomatic T cells Viral load viral replication [DOI] 10.3390/jcm10204798 PMC 바로가기 [Article Type] Article
COVID-19 in multiple-myeloma patients: cellular and humoral immunity against SARS-CoV-2 in a short- and long-term view다발성 골수종 환자의 코로나19: 단기 및 장기 관점에서 SARS-CoV-2에 대한 세포 및 체액 면역Case Reports Published on 2021-10-182022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] MERS, SARS, 진단, 치료기술, [키워드] Affect affecting anti-SARS-CoV-2 antibody antibody levels Antibody titer Antibody titers CD4+ T-cell cell activation cellular Cellular immune response Clinical management Combination Continuous Course COVID-19 Decision-making deficiency detectable diagnosed with COVID-19 Disease progression help humoral Humoral immunity Hypogammaglobulinemia IgA IgG antibodies IgM IgM and IgG immune response Immunity immunodeficiency immunological immunomodulatory drugs Immunosuppression infections information inhibitors Innate immunity Isolation lenalidomide Measures memory monoclonal antibodies monoclonal antibody Multiple Multiple myeloma Myeloma neutralizing antibody titers neutropenia Patient performed positive proteasome receiving recommendation remained robust SARS-CoV-2 supplementary material supportive therapy T cell T cell activation T-cell tested the patient therapy treated Treatment underlying disease virus-neutralizing virus-neutralizing antibody [DOI] 10.1007/s00109-021-02114-x PMC 바로가기 [Article Type] Case Reports
Attenuated activation of pulmonary immune cells in mRNA-1273–vaccinated hamsters after SARS-CoV-2 infectionResearch Article Published on 2021-10-152023-06-16 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] Adaptive immunity bioinformatics Cellular immune response immunology Vaccines [DOI] 10.1172/JCI148036 PMC 바로가기 [Article Type] Research Article
The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children소아에서 과염증성 다기관 염증 증후군의 자가면역 시그니처Article Published on 2021-10-152022-09-11 Journal: The Journal of Clinical Investigation [Category] 바이오마커, 유전자 메커니즘, [키워드] Admission Analysis anti-Spike IgG antigenic antigens autoantibodies autoantibody autoantigen Autoimmune Autoimmune diseases Autoimmunity B cell BCR Cellular immune response children Cluster Coagulation coagulation pathways Combination complement contributing to COVID-19 Cytokines expressed Factor Genes heavy chain humoral immune responses Hyperinflammatory identify IgG IGHV immune immune responses Immunoglobulin Immunopathogenesis Inflammation inflammation markers Inflammatory Inflammatory response intensive care intensive care unit admission manifestation Mild MIS-C Multiorgan neutrophil neutrophil activation neutrophil response pathogenic pathway Patient Previous studies previous study proteomics receptor RNA sequencing SARS-COV-2 infection sequence Sequencing serum superantigen syndrome T cell T cell receptor TCR tissue damage TRBV11-2 Treatment Usage variable region [DOI] 10.1172/JCI151520 PMC 바로가기 [Article Type] Article
Humoral and Cellular Responses to mRNA-1273 and BNT162b2 SARS-CoV-2 Vaccines Administered to Hemodialysis PatientsObservational Study Published on 2021-10-012022-10-05 Journal: American journal of kidney diseases : the official [Category] 임상, [키워드] activated acute respiratory syndrome age analyzed antibody Antibody Response Antigen approaches association Barcelona baseline BNT162b2 CD4 cellular Cellular immune response cellular immunity cellular response characterized Clinical outcome comparable coronavirus coronavirus disease COVID-19 COVID-19 vaccines defined dialysis effective vaccine End-stage renal disease End-stage renal disease (ESRD) evaluate evaluated General population Health health authorities Hemodialysis high risk higher risk humoral Humoral response IgG IgG antibody IgG level immunization immunogenicity Immunosuppression Immunosuppressive treatment Infection kidney Laboratory Logistic Messenger RNA Moderna mRNA mRNA vaccine mRNA vaccines mRNA-1273 multicenter cohort study Multiple linear regression multivariable Patient patients patients treated Pfizer-BioNTech positive response proportion rationale receiving reported response SARS-CoV-2 SARS-CoV-2 vaccine secondary outcome Seroconversion seroconverted seronegative setting Spain study outcomes T cell tested the receptor-binding domain vaccination vaccine administration were used [DOI] 10.1053/j.ajkd.2021.06.002 PMC 바로가기 [Article Type] Observational Study
Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality그룹 IIA 분비 포스포리파제 A2는 COVID-19 사망률로 이어지는 병리생물학과 관련이 있습니다Clinical Trial Published on 2021-10-012022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, [키워드] Analysis biochemical analyses biochemical analysis Blood urea nitrogen catalytically active cellular and molecular Cellular and molecular mechanisms Cellular immune response central node circulating clinically Cohort COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 mortality COVID-19 patient death Deceased Decision tree died disease severity elevated fatal COVID-19 group hypoxia identify immune independent Inflammation inhibitor kidney dysfunction machine learning mechanism median value metabolite Mild Mild disease mitochondrial mitochondrial dysfunction Molecular pathology multiple organ dysfunction nitrogen organ dysfunction pathology Patient performed Phospholipase A2 plasma plasma sample plasma samples Random forest reduce regression analysis responsible secreted severe COVID-19 significantly Stratification survivor tested the median therapeutic target urea variable with mild disease [DOI] 10.1172/JCI149236 PMC 바로가기 [Article Type] Clinical Trial
The ROMANOV study found impaired humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in virus-unexposed patients receiving maintenance hemodialysisROMANOV 연구는 유지 혈액투석을 받고 있는 바이러스에 노출되지 않은 환자에서 SARS-CoV-2 mRNA 백신에 대한 손상된 체액 및 세포 면역 반응을 발견했습니다Article Published on 2021-10-012022-09-12 Journal: Kidney international [Category] MERS, SARS, 진단, [키워드] absence Analysis Anti-RBD IgG Anti-spike benefit BNT162b2 CD4 CD8 Cell Cellular immune response circulation Complete correlated COVID-19 COVID-19 in patient death dose effector generate healthy volunteer healthy volunteers Hemodialysis high risk humoral IgG immune immune response immune responses immunosuppressive Infection injection interferon less mRNA vaccine mRNA vaccines naïve of BNT162b2 Patient RBD receiving Receptor binding domain SARS-CoV-2 SARS-CoV-2 virus significantly T cell T cells therapy vaccination Vaccine vaccine injection virus weakened were excluded were measured [DOI] 10.1016/j.kint.2021.07.005 PMC 바로가기 [Article Type] Article
Unmethylated CpG motif-containing genomic DNA fragments of bacillus calmette-guerin improves immune response towards a DNA vaccine for COVID-19메틸화되지 않은 CpG 모티브를 함유한 바실러스 칼멧-게린의 게놈 DNA 단편은 COVID-19에 대한 DNA 백신에 대한 면역 반응을 향상시킵니다Article Published on 2021-10-012022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus addition adjuvant Antibody titers B.1.1.7 Bacillus Calmette-Guérin BALB/c mice BC01 adjuvant caused Cellular immune response coronavirus coronavirus disease coronavirus- COVID-19 CpG disease DNA DNA fragment DNA vaccine effective elicit expressing Genome Genomic DNA humoral immune response immune responses IMPROVE mice neutralize neutralizing antibody Neutralizing antibody titer neutralizing antibody titers pandemic produced respiratory SARS-CoV-2 SARS-CoV-2 spike protein sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein tested the SARS-CoV-2 unmethylated Vaccine vaccine candidate variants [DOI] 10.1016/j.vaccine.2021.08.103 PMC 바로가기 [Article Type] Article