High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19
높은 처리량, 단일 사본 시퀀싱은 급성 COVID-19 동안 체액 면역 증가와 일치하는 SARS-CoV-2 스파이크 변이체를 보여줍니다
Clinical Trial
[키워드] acute COVID-19
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
acute respiratory syndrome coronavirus-2
Analysis
Antibody binding
Antiviral
antiviral drug
antiviral therapies
antiviral therapy
applied
approach
arising
autologous antibodies
binding
Cell culture
clearance
Clinical outcome
Clustering
contribute
coronavirus
coronavirus disease
Coronavirus disease 2019
Coronavirus-2
COVID-19
cross-sectional analysis
detect
detectable
domain
epitope
evade
Evolution
exhibit
Frame
furin
furin cleavage site
Genetic
genetic diversity
Genome
genomic RNA
Haplotype
help
Humoral immunity
immune response
immune responses
Immune-mediated
in vitro
in vivo
increase in
independent
individual
individuals with COVID-19
infected individual
infected individuals
infecting
initial
intra-individual
longitudinal analysis
Mutation
mutations
Non-synonymous mutation
NTD
one individual
participant
Pathogenesis
predominant
regions
respiratory
reveal
SARS-CoV-2
SARS-CoV-2 evolution
SARS-CoV-2 genome
SARS-CoV-2 genomes
SARS-CoV-2 replication
SARS-CoV-2 spike protein
SARS-CoV-2 spike variant
SARS-CoV-2 variant
SARS-CoV-2 variants
selected
selection of variant
sequence
Sequencing
sequencing technology
serum
serum sample
Severe acute respiratory syndrome
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus-2
Spike protein
study participant
surface protein
surface proteins
susceptibility
the SARS-CoV-2
Time frame
upper respiratory sample
variant
variants
Variation
virion
virus
virus RNA
virus variants
viruses
WA-1 reference
with COVID-19
[DOI] 10.1371/journal.ppat.1009431 PMC 바로가기 [Article Type] Clinical Trial
[DOI] 10.1371/journal.ppat.1009431 PMC 바로가기 [Article Type] Clinical Trial