Genome-scale CRISPR screening for modifiers of cellular LDL uptake
세포 LDL 흡수 조절제에 대한 게놈 규모 CRISPR 스크리닝
Research Article
[키워드] absence
applied
atherosclerotic
Blood
candidate
candidate gene
cardiovascular disease
cardiovascular diseases
Cell
cell line
cell types
cellular
characterized
cholesterol
cholesterol homeostasis
circulating
circulation
Concordance
conditions
Coverage
CRISPR
Critical
expression
functional
functions
Generalizability
Genetic
genetic determinant
genetic determinants
genetic interactions
Genome
greater
gRNA
hepatocytes
HUH7 cells
Human genome
hypercholesterolemia
initial
Interaction
internal positive controls
involved
LDL
LDLR
Lipoproteins
liver cells
Low-density lipoprotein
low-density lipoproteins
mechanism
negative controls
pathway
presence or absence
receptor
regulated
Regulation
removal
risk
risk factor
significantly
specificity
stroke
synthesis
tested
Transferrin
while
[DOI] 10.1371/journal.pgen.1009285 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1009285 PMC 바로가기 [Article Type] Research Article