Molecular characterization of porcine epidemic diarrhoea virus (PEDV) in Poland reveals the presence of swine enteric coronavirus (SeCoV) sequence in S geneResearch Article Published on 2021-10-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Analysis Antigen circulating classical COE Complete concerning conserved contagious coronavirus diarrhoea disease Epidemic epitope etiological agent European Genome identify knowledge molecular morbidity and mortality neutralizing epitope parents PEDV Phylogenetic analysis Poland positive positive result quantitative real-time PCR reveal reverse transcription RT-qPCR S gene sequence single-stranded RNA virus strain Strains substitutions tested unique viral disease virus virus strains [DOI] 10.1371/journal.pone.0258318 PMC 바로가기 [Article Type] Research Article
Distant residues modulate conformational opening in SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 구조적 개방을 조절하는 먼 잔류물408 Published on 2021-10-262022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, [키워드] A570D ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all-atom molecular dynamics simulations Analysis antibody applied attachment binding conformational conformational change conserved contagious coronavirus correlation correlations COVID-19 D614G mutation Data analysis Distant drug drug design drug resistance effort Epidemics event focus Health crisis host cells hotspot identify implication independent independent component analysis Infection initiated involved membrane modulate molecular molecular biophysics molecular dynamics Molecular dynamics simulation monoclonal antibodies monoclonal antibody multiple coronaviruses mutant Mutation mutations new strain Novel coronavirus Outbreaks pandemic predicted Protein public health crisis RBD RBD region receptor Receptor-binding domain Region residue residues respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Significance Significant Spike protein Spike proteins statistical mechanics the RBD the receptor-binding domain the spike protein therapeutic Therapeutics Transmissibility treat Vaccine virulence virus structure [DOI] 10.1073/pnas.2100943118 PMC 바로가기 [Article Type] 408
A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®면역 저하 환자에서 승인된 SARS-CoV-2 백신을 평가하기 위한 시험 플랫폼: mRNA 백신 Comirnaty®와 COVID-19 mRNA를 비교하는 파일럿 시험을 위한 첫 번째 하위 프로토콜 Vaccine Moderna®Study Protocol Published on 2021-10-212022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] Antibody Response approaches approved baseline clinical trial Cohort cohorts collected data confidence interval contagious Controlled trial coronavirus coronavirus SARS-CoV-2 COVID-19 disease Efficacy Efficacy and safety eligible Endpoint endpoints favor feasibility first vaccination flexible foundation Frame groups highest HIV HIV patient HIV patients Immunocompromised Immunocompromised patient Immunocompromised patients information Intervention Medical conditions Missing data mRNA mRNA vaccine multicenter non-inferiority margin Open-label Organ transplant outcome pandemic Patient patient recruitment Pfizer/BioNTech pilot study Platform trial positive antibody response primary clinical outcome Program proportion protocol randomization Randomized Randomized controlled trial Randomized controlled trial, HIV RCT reached reactivity receiving recipients required Sample size SARS-CoV-2 SARS-CoV-2 vaccine Science Statistical power STCS Switzerland Transplant treatment arm Trial trial platform Trial registration two-sided type I type I error Vaccine Wuhan Wuhan, China [DOI] 10.1186/s13063-021-05664-0 PMC 바로가기 [Article Type] Study Protocol
Structure-guided antibody cocktail for prevention and treatment of COVID-19코로나19 예방 및 치료를 위한 구조유도항체 칵테일Research Article Published on 2021-10-212022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 진단, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antivirals approach characterization chimeric chimeric antibodies Combination complex contagious coronavirus COVID-19 COVID-19 pandemic cryo demonstrated develop development disease Disease progression drug resistance drugs effective Efficacy Epitopes escape mutant escape mutants group host immunity in vitro in vivo Microscopy mitigate mutants neutralization activity neutralization test neutralize Neutralizing antibodies neutralizing antibody non-overlapping epitope non-overlapping epitopes Patient plaque reduction neutralization Plaque reduction neutralization test Post-infection Prevent prevent disease progression PRNT Prophylactic pseudovirus RBD Receptor-binding domain receptor-binding motif reduce respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein suggested target the RBD the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic antibodies therapeutic drug therapeutic effect therapy treat Treatment utility variants of SARS-CoV-2 Viral Viral load [DOI] 10.1371/journal.ppat.1009704 PMC 바로가기 [Article Type] Research Article
Analysis of the Delta Variant B.1.617.2 COVID-19Review Published on 2021-10-212022-10-31 Journal: Clinics and Practice [Category] COVID-19, [키워드] Alpha AstraZeneca B.1.617.2 contagious country COVID-19 Delta delta variant dominant Efficacy Infection infections information Moderna Pfizer/BioNTech reduced reported SARS-CoV-2 variants Vaccine variant [DOI] 10.3390/clinpract11040093 PMC 바로가기 [Article Type] Review
Dental Healthcare Amid the COVID-19 PandemicCOVID-19 팬데믹 속 치과 의료Review Published on 2021-10-202022-09-12 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Aerosols affected Care carrier carriers connection Contact contagious coronavirus coronavirus disease COVID-19 dental Dental health dental procedures Dental Treatment dentist dentistry Diagnosis disguise earth effective Evolution Features Health Health care highlight Infection mitigate molecular Novel coronavirus novel coronavirus disease pandemic Patient point-of-care produced provided Psychological Research Respiratory droplets risk Saliva SARS-CoV-2 social distancing the patient transmitted unique vaccination virus [DOI] 10.3390/ijerph182111008 PMC 바로가기 [Article Type] Review
The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination RouteArticle Published on 2021-10-182022-10-28 Journal: Veterinary Sciences [Category] COVID-19, [키워드] antigens artificial ribonuclease bronchitis caused characterized chickens contagious control group Coronaviridae coronavirus disease dose drug Effectiveness experimental group Gamma genomic hematogenous humans Hypothesis IBV inflammatory change inflammatory reaction inoculated insight intestine intestines less lung lung damage Lungs mechanism Model monoglyceride lauryl acid novel other coronavirus pathology predominant probe proportion reproductive organ Respiratory system route SARS-CoV-2 Silver nanoparticles similarity subsequent suggested the SARS-CoV-2 vaccine strain viral particle virucidal virucidal drugs virus virus RNA was tested [DOI] 10.3390/vetsci8100239 PMC 바로가기 [Article Type] Article
Deep Learning Based Early Detection Framework for Preliminary Diagnosis of COVID-19 via Onboard Smartphone Sensors온보드 스마트폰 센서를 통한 COVID-19 사전 진단을 위한 딥 러닝 기반 조기 감지 프레임워크Article Published on 2021-10-152022-09-10 Journal: Sensors (Basel, Switzerland) [Category] MERS, SARS, 치료기술, [키워드] Accuracy acid adverse impact affected approach artificial intelligence Blood blood test carriers Chest CT clinical analysis computer computer tomography contagious coronavirus coronavirus disease country COVID-19 COVID-19 pandemic COVID-19 prediction deep deep learning detect detection diagnosis of COVID-19 domain Early detection Experimental result experimental results feature framework gold gold standard healthcare Healthcare system Healthcare systems hospital in-person visit learning limit NAAT pandemic positive prediction framework Preliminary Diagnosis Prevent provide reduce robust sensor simple Smartphone smartphone sensors Spread temperature the patient treated variety [DOI] 10.3390/s21206853 PMC 바로가기 [Article Type] Article
Changes in Dietary Patterns and Clinical Health Outcomes in Different Countries during the SARS-CoV-2 PandemicReview Published on 2021-10-152022-10-31 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome approach avoidance bioactive compounds categories caused change clinical Community Comorbidity conditions contagious Contamination coronavirus Coronavirus disease 2019 COVID-19 cross-contamination diet dietary Evidence Factor Factors food hygiene globe Government healthy hygiene immune response immune system include Infection initial lifestyle Masks measure Mortality outcomes pandemic pathology pattern persist persistence physical prevention promote protocol reduce required risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission Spread Stage Support the SARS-CoV-2 virus waned while [DOI] 10.3390/nu13103612 PMC 바로가기 [Article Type] Review
A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world여러 국가와 세계에서 SARS-CoV-2의 알파 변이가 급격히 증가하는 것을 설명하기 위한 매우 간단한 모델Article Published on 2021-10-152022-09-11 Journal: Virus research [Category] SARS, 변종, 치료기술, [키워드] Alpha B.1.1.7 contagious coronavirus country dominant Frequency Lineage Local outbreak parameter Region SARS-CoV-2 virus shown Spread Transmissibility variant variant of SARS-CoV-2 wild type [DOI] 10.1016/j.virusres.2021.198531 PMC 바로가기 [Article Type] Article