Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registryRandomized Controlled Trial Published on 2021-10-022022-10-04 Journal: European Journal of Medical Research [Category] MERS, SARS, 임상, [키워드] 28-day mortality 95% CI 95% confidence interval adjusted adjusted odds ratio administration antagonist Bacteremia C-reactive protein Characteristics clinical Clinical characteristics clinical outcomes cohort study collected Combination combination therapy combinations conducted coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 COVID-19 patient COVID-19 patients Critical Critical care Critically ill Dexamethasone Discordance dose driver dysfunction eligibility criteria ENhance Epidemiology evaluate Evidence groups help High-dose Hyperinflammatory ICU admission identify illness immunomodulatory therapy incidence rate interleukin-6 interleukin-6 receptor Interleukin-6 receptor antagonist interquartile Invasive mechanical ventilation low-dose majority material mechanically ventilated median median age Medicine multicenter network not differ outcome Patient phenotype preliminary report Randomized controlled trial receiving receptor recommendations regimens respiratory Result sarilumab Society steroid Steroids supplementary material the patient the timing therapy Tocilizumab university Variation Ventilator-free days [DOI] 10.1186/s40001-021-00591-x PMC 바로가기 [Article Type] Randomized Controlled Trial
Long-term survival of mechanically ventilated patients with severe COVID-19: an observational cohort studyResearch Published on 2021-10-022022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome administration age ARDS cohort study coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 develop diabete digestive dosage Factor help Hospital admission Hospital stay hypoxemic ICU ICU admission in-hospital mortality Infection intensive care unit intubation Invasive mechanical ventilation invasive ventilation long-term survival lymphocyte male mechanically ventilated patient median age Methylprednisolone Mortality multicentre nasopharyngeal sample National neutrophil noninvasive noninvasive respiratory Noninvasive ventilation Observational cohort study outcome participant Patient patients with COVID-19 Pneumonia polymerase chain positive positive pressure ventilation potential treatments Predictive Primary outcome Probability Ratio real time Registered Respiratory failure Result risk stratification SARS-CoV-2 secondary selective severe COVID-19 Spain supplementary material Support survival survival rate [DOI] 10.1186/s13613-021-00929-y PMC 바로가기 [Article Type] Research
Concurrent COVID-19 and Pneumocystis jirovecii pneumonia: The importance of radiological diagnostic and HIV testingCase Report Published on 2021-10-022022-10-04 Journal: Radiology Case Reports [Category] 진단, [키워드] acute respiratory syndrome aerosol-generating procedure BAL BALF caused CD4+ changed chest X-ray Clinical features Co-infection concurrent coronavirus Coronavirus disease 2019 Corticosteroid COVID-19 COVID-19 patient diagnose Diagnosis diagnostic discharged dose feature fungi healthcare HIV HIV serology HIV testing HIV treatment Human immunodeficiency virus Infection lavage Methylprednisolone microorganisms morbidity and mortality pandemic Patient patients PJP Pneumonia positive presenting public health radiological Radiological Diagnosis reduce Remdesivir risk of COVID-19 SARS-CoV-2 sputum Transmission treat treated Treatment with COVID-19 worse prognosis [DOI] 10.1016/j.radcr.2021.09.002 PMC 바로가기 [Article Type] Case Report
Mucormycosis and COVID-19: An epidemic within a pandemic in IndiaMucormycosis와 COVID-19: 인도에서 유행하는 전염병Observational Study Published on 2021-10-012022-09-11 Journal: Mycoses [Category] 임상, 치료제, [키워드] age Anti-viral Antibiotics biochemical cause Characteristics clinical Clinical features Clinical presentations collected consecutive patient coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids Course COVID-19 COVID-19 diagnosis COVID-19 illness COVID-19 infection COVID-19 patient COVID-19 patients demography diabete diabetes Diabetes Mellitus diagnosed Diagnosis died disease elapsed Epidemic evaluated Factors glycaemic control high mortality Immunosuppressed increase India Infection invasive ventilation majority mechanical ventilation Medical conditions medication MOST Mucormycosis occur outcome oxygen oxygen supplementation pandemic Patient patients with COVID-19 Pneumonia populations required risk Secondary infection secondary infections subject suffered suspicion systemic corticosteroids the patient Treatment use of corticosteroid vaccine dose were recorded widespread [DOI] 10.1111/myc.13353 PMC 바로가기 [Article Type] Observational Study
COVID-19-associated acute respiratory distress syndrome (CARDS): Current knowledge on pathophysiology and ICU treatment – A narrative reviewReview article Published on 2021-10-012022-10-05 Journal: Best Practice & Research Clinical Anaesthesiology [Category] 치료법, [키워드] Activation acute lung injury acute respiratory distress acute respiratory syndrome addition alveolar ARDS Clinical management Comorbidity coronavirus Corticosteroid COVID-19 Critical care current disease effort endothelial Endotheliitis Health homeostasis ICU ICU care ICU treatment Immune cell immune cells include induce Inflammation intensive care knowledge mechanism medical intervention narrative review Pathomechanism pathophysiological perspective pathophysiology patients pulmonary fibrosis resulting SARS-CoV-2 SARS-CoV-2 pandemic Sepsis syndrome Thromboembolism Treatment treatment approaches vascular thrombosis Ventilation [DOI] 10.1016/j.bpa.2020.12.011 [Article Type] Review article
A Seroprevalence Study of Anti-SARS-CoV-2 Antibodies in Patients with Inflammatory Bowel Disease during the Second Wave of the COVID-19 Pandemic in Italy이탈리아에서 COVID-19 팬데믹의 2차 파동 동안 염증성 장 질환 환자에서 Anti-SARS-CoV-2 항체의 혈청유병성 연구Article Published on 2021-10-012022-09-12 Journal: Medicina [Category] MERS, SARS, 진단, [키워드] aims analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody association Characteristics close contact Colitis collected contact with control group Corticosteroid Corticosteroids COVID-19 Crohn’s disease determine determined by enrolled extension greater groups healthcare worker IBD Inflammatory bowel disease Italy likelihood Mask material mesalazine not significantly different Patient patients phenotype Prevalence receiving risk risk factor SARS-CoV-2 SARS-CoV-2 positive individual SARS-CoV-2 positive individuals second Seropositivity Seroprevalence serum shown significantly therapy Treatment ulcerative colitis was collected Wave [DOI] 10.3390/medicina57101048 PMC 바로가기 [Article Type] Article
COVID-19-related outcomes in immunocompromised patients: A nationwide study in KoreaResearch Article Published on 2021-10-012022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval adjusted adjusted odds ratio Analysis approach baseline baseline characteristics calculated CIs Comorbidities Comorbidity coronavirus disease Corticosteroid COVID-19 COVID-19 patient determine Diagnosis had more higher risk HIV/AIDS identify Immunocompromised Immunocompromised patient immunocompromised status Immunosuppressant in-hospital mortality in-hospital mortality rate increased risk malignancy Mortality multivariable logistic regression Older organ outcome Probability Result risk risk factor severe COVID-19 significantly higher significantly increased Treatment vulnerable patients Weighting with COVID-19 [DOI] 10.1371/journal.pone.0257641 PMC 바로가기 [Article Type] Research Article
Bacterial and fungal ventilator associated pneumonia in critically ill COVID-19 patients during the second wave2차 유행 동안 중환자 COVID-19 환자의 박테리아 및 곰팡이 인공 호흡기 관련 폐렴Article Published on 2021-10-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 치료기술, [키워드] 95% CI 95% confidence interval Acinetobacter admitted to ICU antimicrobial antimicrobial resistance antimicrobial susceptibility Aspergillus Bacteria Bacterial Bacterial infections Candida caused Chest collected coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients Culture diabetes Diabetes Mellitus diagnosed disease element followed by fungal fungi Hypothyroidism ICUs identify intensive care unit intensive care units isolate isolates Klebsiella pneumoniae MDR mechanical ventilation Mucor multi outcomes pandemic Patient PDR Pneumonia pneumoniae positive respiratory Respiratory samples risk factor Risk factors SARS-CoV2 second wave specimen specimens subsequent susceptibility Tocilizumab Treatment VAP ventilator Ventilator associated pneumonia [DOI] 10.1016/j.jiph.2021.08.003 PMC 바로가기 [Article Type] Article
COVID-19 and mucormycosis superinfection: the perfect storm코로나19와 점막염 중복감염: 퍼펙트 스톰Review Published on 2021-10-012022-09-12 Journal: Infection [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome addition approach Case report case sery clinical feature combined use coronavirus Corticosteroid corticosteroids therapy COVID-19 COVID-19 disease severity COVID-19 pandemic COVID-19 patient Critically ill patient develop Diabetes Mellitus Diabetic disease epidemiological Factor fatality Fungal infection immune immunosuppressive agent incidence India infected with SARS-CoV-2 Infection invasive modulating Mucormycosis outcome pandemic Patient Patients with cancer patients with COVID-19 Prevalence recovered patients reported risk SARS-CoV-2 second wave severity of COVID-19 significant increase spore Steroids transplants treated [DOI] 10.1007/s15010-021-01670-1 PMC 바로가기 [Article Type] Review
In silico drug repurposing in COVID-19: A network-based analysisCovid-19의 Silico Drug Reperhing에서 : 네트워크 기반 분석Article Published on 2021-10-012022-08-31 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, 신약개발, 임상, 치료제, [키워드] addition Analysis analyzed antibodies Anticoagulants approach Blood cells bowel Central nervous system clinical clinical setting clinical trial clinical trials compounds conditions Corticosteroid Corticosteroids corticosteroids) COVID-19 COVID-19 patient COVID-19 patients de novo drug Drug discovery Drug repurposing examined faster healthy subjects heparin identify Inflammatory bowel disease inhibitor mandatory patients with COVID-19 priority public health emergency SARS-CoV-2 pandemic SCN5A septic Septic shock Shock transcriptomic data treat vaccination whole blood cell whole blood cells [DOI] 10.1016/j.biopha.2021.111954 PMC 바로가기 [Article Type] Article