Type III interferons disrupt the lung epithelial barrier upon viral recognition
Report
[키워드] aberrant immune response
acute respiratory syndrome
airway
Antiviral
antiviral immunity
bacterial superinfections
cause
characterized
Clinical practice
contribute
coronavirus
coronavirus disease
COVID-19
COVID-19 patient
Critical
critical COVID-19 patient
dendritic cell
disrupt
driving
elicit
Endemic
engage
ENhance
epithelial
Evidence
expressed
expression
functions
IFN
IFN signaling
IFN-stimulated gene
IFN-α
IFN-β
IFN-λ
IFNs
Immune cell
immunopathology
increase
indicate
induce
Infection
influenza infection
Influenza virus
inhibiting
interfere
ISGs
Local
Lower respiratory tract
lung
lung epithelial
lung epithelium
Major
mice
morbidity
Mortality
Mounting
mucosal surface
Necrosis
p53
parameter
Pathogenesis
pathophysiological
Patient
Peripheral blood
produced
proinflammatory
proliferation
respiratory viral infections
response
responses
RNA viruses
SARS-CoV-2
Science
secreted
Severe case
severity
susceptibility
therapeutic
thought
Transcription
Trigger
turn
Type
type I
Type I IFN
Type III IFN
type III interferon
viral burden
viral infections
viral respiratory disease
viral respiratory infections
Viral RNA
viruses
[DOI] 10.1126/science.abc3545 PMC 바로가기 [Article Type] Report
[DOI] 10.1126/science.abc3545 PMC 바로가기 [Article Type] Report