Helmet Non-Invasive Ventilation for COVID-19 Patients (Helmet-COVID): study protocol for a multicentre randomised controlled trialCOVID-19 환자를 위한 헬멧 비침습적 인공호흡기(Helmet-COVID): 다기관 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2021-08-262022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 adult intensive & all-cause mortality approvals cohorts conducted COVID-19 COVID-19 pneumonia Critical Critical care Effectiveness enrolled Ethics hypoxaemic respiratory failure institutional review board institutional review boards Intensive intention-to-treat interim analysis multicentre NIV Patient peer-reviewed per-protocol Pneumonia Pragmatic Primary outcome randomised controlled trial reduce mortality registration number Respiratory failure respiratory medicine (see thoracic medicine) Respiratory Support study group Study protocol Thoracic usual care usual care alone Ventilation [DOI] 10.1136/bmjopen-2021-052169 PMC 바로가기 [Article Type] Article
Substantial impact of post-vaccination contacts on cumulative infections during viral epidemics바이러스 전염병 동안 누적 감염에 대한 예방 접종 후 접촉의 실질적인 영향Research Article Published on 2021-08-262022-09-11 Journal: F1000Research [Category] MERS, SARS, 변종, [키워드] Affect Alter analyzed antibiotic Behavior condition Contact Course cumulative decrease defined deterministic model distribution Epidemic Epidemics epidemiological Evolution Exacerbation identify immune Impact individual Infection infections inoculated Intensive less limitation low-dose magnitude Mitigation mutant naïve Novel coronavirus novel coronavirus SARS-CoV-2 Outbreaks parameter populations representing resistant mutants SARS-CoV-2 vaccination Seven Simulation susceptible vaccination Vaccine variant viral epidemics Virus infection; epidemics; vaccination; escape mutants; contact limitation [DOI] 10.12688/f1000research.52341.2 PMC 바로가기 [Article Type] Research Article
Double Trouble: Dengue Followed by COVID-19 Infection Acquired in Two Different Regions: A Doctor’s Case Report and Spatial Distribution of Cases in Presidente Prudente, São Paulo, BrazilCase Report Published on 2021-08-252022-10-29 Journal: Tropical Medicine and Infectious Disease [Category] COVID-19, [키워드] Acquired Analysis Brazil carried Case report Clinical diagnosis Cluster Clusters Community country COVID-19 COVID-19 case COVID-19 cases COVID-19 epidemic COVID-19 infection death Dengue Diseases distribution Endemic epidemiological followed by Health care worker health care workers highlight hospital IMPROVE infections Intensive Intervention Lower management Mild Neighborhoods occurred outbreak Patient presenting public health public health authority reached Region report resulting risk Simultaneous spatiotemporal Surveillance Symptom virus [DOI] 10.3390/tropicalmed6030156 PMC 바로가기 [Article Type] Case Report
Superspreaders drive the largest outbreaks of hospital onset COVID-19 infectionsResearch Article Published on 2021-08-242022-10-31 Journal: eLife [Category] COVID-19, MERS, [키워드] Algorithm applied build Cambridge caused Cluster collected COVID-19 infection COVID-19 pandemic determine develop effective events Factor finding First wave foundation generate Genetic genetic data genetic information genetic material global public health HCWs Health care worker help heterogeneity hospital Hospital wards Hospital-acquired infection hospitals IMPROVE incidence individual individuals infected individuals Infection infection control information Intensive measure NHS nosocomial Nosocomial transmission notable outbreak Patient provide provided recorded reduce reporting symptoms researcher Retrospective analysis Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission sequence sick Spread spreads superspreader swabbing Symptoms the epidemic the SARS-CoV-2 virus These data Transmission transmission of SARS-CoV-2 transmitted Trust university unlikely viral genome sequence Viral transmission virus virus spread vulnerable patient were infected [DOI] 10.7554/eLife.67308 PMC 바로가기 [Article Type] Research Article
A staged approach to address youth unresponsive to initial obesity intervention: a randomized clinical trial Research Published on 2021-08-202022-10-05 Journal: International journal of obesity (2005) [Category] 임상, [키워드] Analysis approach benefit BMI Clinical treatment decrease develop Efficacy examined female greater greater decrease groups Hispanic Houston ILI improvement indicate individual initial Intensive Intervention linear modeling maintain maintenance obesity outcome parental participant pediatric percentile physical protocol Randomized randomized clinical trial Randomized controlled trial receiving recruited Registered Result significantly Treatment Trial [DOI] 10.1038/s41366-021-00940-0 [Article Type] Research
Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units중증 지역사회획득폐렴(MULTI-CAP) 환자의 항생제 노출 기간을 줄이기 위해 광범위 호흡 다중 PCR과 프로칼시토닌을 함께 사용: 프랑스어 집중적으로 수행된 다기관, 병렬 그룹, 공개 라벨, 개별 무작위 시험 케어 유닛Randomized Controlled Trial Published on 2021-08-182022-09-12 Journal: BMJ Open [Category] MERS, 임상, 진단, [키워드] 1:1 adult intensive & adult thoracic medicine Algorithm antibiotic Antibiotics approach approved Bacterial Biomarker clinical clinical criteria clinician Combined combined use Committee community-acquired pneumonia conducted control arm Critical Critical care days alive Declaration of Helsinki Diagnosis diagnostic Diagnostic microbiology drug Ethics excluded French Hypothesis Intensive intensive care intensive care unit intervention arm molecular molecular diagnostics molecular test multicentre Multiplex PCR Open-label parallel-group parenchymal Patient peer-reviewed performed Person Pneumonia primary endpoint procalcitonin protection public health randomisation randomised Randomised trial reduce reducing Registered respiratory infections Safety selection pressure Spread submitted the patient Thoracic Treatment Trial usual care written Informed Consent [DOI] 10.1136/bmjopen-2020-048187 PMC 바로가기 [Article Type] Randomized Controlled Trial
Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?커뮤니티 환경의 살생물제 내성 및 항생제 내성 및 인간에게 직접 전염 위험: COVID-19 동안 커뮤니티 전체 표면 소독의 의도하지 않은 결과?Review Published on 2021-08-152022-09-11 Journal: Environmental pollution (Barking, Essex : 1987) [Category] SARS, 변종, 유전자 메커니즘, [키워드] Ammonium antibiotic Antibiotic resistance antimicrobial antimicrobial resistance Bacteria Bacterial Bacterial pathogens biocide Community compounds consequence Contact Contact surface coronavirus COVID-19 disinfectant drug drug resistance Ethanol Evidence exacerbate feasible fingers gene transfer growth hands highlight horizontal gene Horizontal gene transfer humans hydrogen hydrogen peroxide hypochlorite impacted infection control ingredient Intensive intrinsic Laboratory linkage LIPS mechanism membrane mitigate Mutation Novel coronavirus pandemic Pathogens REALITY Regulatory risk risk factor SARS-CoV-2 scenario sodium sodium hypochlorite suggested these compounds Tolerance transfer upregulation virus spread while [DOI] 10.1016/j.envpol.2021.117074 PMC 바로가기 [Article Type] Review
Cellular and Molecular Effects of SARS-CoV-2 Linking Lung Infection to the Brain폐 감염과 뇌를 연결하는 SARS-CoV-2의 세포 및 분자 효과Review Published on 2021-08-132022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Activation alveolar macrophage antibody anticipated autoantibody Brain caused Central nervous system CNS COVID-19 COVID-19 outbreak Cytokine storm detrimental effect Effect evaluate global pandemic hypoxia immune indirect effect Infection infiltration Intensive irreversible damage lung lung capacity microglia neuroinvasion Neuroinvasive neurological Neurological symptom neurons number of infected raising Research respiratory symptoms SARS-CoV-2 severe COVID-19 Spread the SARS-CoV-2 viral disease [DOI] 10.3389/fimmu.2021.730088 PMC 바로가기 [Article Type] Review
Pooling of Samples for SARS-CoV-2 Detection Using a Rapid Antigen TestTropical Diseases Published on 2021-08-052022-10-31 Journal: Frontiers in Tropical Diseases [Category] COVID-19, [키워드] Antigen coronavirus disease costly COVID-19 detection diagnostic Efficiency evaluated expand Intensive molecular assays nasal swab pandemic polymerase chain pooled testing methodology pooling positive sample Rapid rapid antigen test reduce cost resource RT-PCR Sample SARS-CoV-2 SARS-CoV-2 surveillance Schools significantly specimen Surveillance Test while [DOI] 10.3389/fitd.2021.707865 PMC 바로가기 [Article Type] Tropical Diseases
NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolismTools and Resources Published on 2021-08-032022-10-31 Journal: eLife [Category] COVID-19, [키워드] alleviate Analysis anticancer candidate drug Cell COVID-19 database dataset drug drug clustering drug design drug metabolic fate drug similarity E. coli enzyme Enzyme inhibition evaluate explain golden standard high risk Human human host identify include inhibitory Intensive ligand-based drug discovery malaria mechanism metabolism metabolite nutraceuticals P. falciparum reactive reactivity reduce Research resource Side effects similarity small molecule targets toxicities Toxicity unique [DOI] 10.7554/eLife.65543 PMC 바로가기 [Article Type] Tools and Resources