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The Landscape of COVID-19 Research in the United States: a Cross-sectional Study of Randomized Trials Registered on ClinicalTrials.Gov

미국의 COVID-19 연구 환경: ClinicalTrials.Gov에 등록된 무작위 시험의 횡단면 연구

Article

Published on 2022-01-012022-09-11
Journal: Journal of General Internal Medicine [Category] SARS, 임상, 치료기술,

[키워드] antiviral medication Antiviral medications antivirals capita Characteristics Chloroquine chloroquine/hydroxychloroquine clinical endpoint clinical trial clinical trials Composite conducted Controlled trial COVID-19 cross-sectional cross-sectional study deaths Descriptive statistics detect diagnosed with COVID-19 distribution effective evaluate excluded followed by Geographic distribution greater highest highlighting Hydroxychloroquine identify immunomodulator Intervention IQR landscape less lowest measure monoclonal antibodies monoclonal antibody Mortality National ongoing trials pandemic participant pathogen people with COVID-19 Phase 3 power Prevent Primary outcome Randomized Randomized controlled trial Randomized controlled trials randomized trial randomized trials reduction in mortality Registered Relative risk resulting risk reduction Sample size SARS-CoV-2 setting severity single trial single-center small molecule Statistical power the median the United State Treatment treatments for COVID-19 Trial trials United States Vaccine Variability Ventilation
[DOI] 10.1007/s11606-021-07167-9 PMC 바로가기 [Article Type] Article

Application of the ARIMA Model to Predict Under-Reporting of New Cases of Hansen’s Disease during the COVID-19 Pandemic in a Municipality of the Amazon Region

COVID-19 팬데믹 동안 아마존 지역의 한 자치단체에서 한센병 신규 사례의 과소 보고를 예측하기 위한 ARIMA 모델의 적용

Article

Published on 2021-12-312022-10-29
Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, 한센병,

Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays

Article

Published on 2021-12-312022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] activities activity acute respiratory syndrome ADME African Analysis B.1.1.7 B.1.351 B.1.617.2 bind Candidates Compound concern coronavirus COVID-19 Cytopathic effect delta variant demonstrated distribution facilitate fusion fusion inhibitor half-maximal inhibitory concentration in vivo India inhibited inhibitor inhibitors inhibitory lowest Major MERS-CoV metabolism Middle East Middle East respiratory syndrome (MERS) oral bioavailability pan-coronavirus potent Potential prefusion prevented respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome (SARS) small molecule South SPR surface plasmon resonance trimer variant variants of concern VOCs
[DOI] 10.3390/v14010069 PMC 바로가기 [Article Type] Article

COVID-19 Vaccines Cost-Effectiveness Analysis: A Scenario for Iran

Article

Published on 2021-12-292022-10-28
Journal: Vaccines [Category] COVID-19,

The role of resilience and coping among Italian healthcare workers during the COVID-19 pandemic

Observational Study

Published on 2021-12-232022-10-05
Journal: La Medicina del lavoro [Category] SARS, 임상,

Confidence and Hesitancy During the Early Roll-out of COVID-19 Vaccines Among Black, Hispanic, and Undocumented Immigrant Communities: a Review

Article

Published on 2021-12-232022-10-30
Journal: Journal of Urban Health : Bulletin of the New York [Category] COVID-19, COVID19(2023년), MERS, SARS,

Immediate and Longer-Term Changes in the Mental Health and Well-being of Older Adults in England During the COVID-19 Pandemic

Research

Published on 2021-12-222022-10-30
Journal: JAMA Psychiatry [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] 95% CI accompanied age Ageing analyzed Anxiety anxiety symptom assessment Autonomy change changed changes changes in clinically cohort study Control COVID-19 COVID-19 pandemic Depression depressive symptom deteriorate Deterioration England English Evidence exposure finding Generalized greater group Health Immediate Importance increases in individual inequality initial introduced later phase less lockdown loneliness longitudinal longitudinal cohort study Los Angeles lowest measure Mental mental health mental health service National objective Older pandemic participant Participants pleasure Point poor quality Prevalence progressed provided psychological Impact Psychological intervention psychosocial stressor Quality of life regression models Relevance repeated Result Self-realization setting Sex significantly Sociodemographic characteristics Support tested the mean University of California Well-being white women
[DOI] 10.1001/jamapsychiatry.2021.3749 PMC 바로가기 [Article Type] Research

A Single Dose SARS-CoV-2 Replicon RNA Vaccine Induces Cellular and Humoral Immune Responses in Simian Immunodeficiency Virus Infected and Uninfected Pigtail Macaques

단일 용량 SARS-CoV-2 레플리콘 RNA 백신은 유인원 면역결핍 바이러스에 감염된 피그테일 원숭이와 감염되지 않은 피그테일 원숭이에서 세포 및 체액 면역 반응을 유도합니다

Immunology

Published on 2021-12-212022-09-12
Journal: Frontiers in Immunology [Category] 진단,

[키워드] Antiretroviral therapy binding CD4 count cellular competent COVID-19 COVID-19 mRNA vaccine COVID-19 vaccine Critical death effective elicited evaluated Evidence expressing highest HIV hospitalizations immune Immunity immunization Immunocompromised immunocompromised individuals immunogenic induce less lowest macaque macaques naïve neutralizing antibody nonhuman primate Pigtail populations Protein provide raise reducing replicon replicon RNA resource response RNA RNA vaccine Safe SARS-CoV-2 SARS-CoV-2 infections Simian single dose SIV spike suppressed T-cell Response Th1 Vaccine vaccine immunogenicity viral burden with HIV
[DOI] 10.3389/fimmu.2021.800723 PMC 바로가기 [Article Type] Immunology

Microfluidic Chip with Two-Stage Isothermal Amplification Method for Highly Sensitive Parallel Detection of SARS-CoV-2 and Measles Virus

Article

Published on 2021-12-192022-10-30
Journal: Micromachines [Category] COVID-19,

Reinforcement learning assisted oxygen therapy for COVID-19 patients under intensive care

Research

Published on 2021-12-172022-10-27
Journal: BMC Medical Informatics and Decision Making [Category] COVID-19,

[키워드] Algorithm averaged Care Characteristics Clinical practice coronavirus disease 19 COVID-19 COVID-19 pandemic COVID-19 patient Critically ill patient cross Electronic health record Health Health status identify IMPROVE independent intensive care intensive care treatment learning lowest management Markov decision process Mortality mortality rate New York outcome oxygen oxygen flow oxygen flow rate Oxygen therapy Patient patients public health reduce reduce mortality rate reduction reduction in reinforcement reinforcement learning resources Result retrospective cohort Standard of care supplemental oxygen supplementary material training data trajectory Treatment university validation cohort with COVID-19
[DOI] 10.1186/s12911-021-01712-6 PMC 바로가기 [Article Type] Research