motif – Page 21 – Communicable Diseases Research

A proposed molecular mechanism for pathogenesis of severe RNA-viral pulmonary infections

Research Article

Published on 2021-01-062022-10-31
Journal: F1000Research [Category] COVID-19, MERS, SARS,

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

경도 높은 처리량 TCR 레퍼토리 프로파일링은 가벼운 COVID-19 감염 후 T 세포 기억 형성의 역학을 보여줍니다

Short Report

Published on 2021-01-052022-09-10
Journal: eLife [Category] 치료기술,

[키워드] adaptive antibodies antiviral immune response caused CD4 CD8 changes in characteristic clonal expansion clone coronavirus COVID-19 COVID-19 infection COVID-19 patients cross-reactive cross-reactivity dataset Diversity donors fraction global pandemic Human immune memory immune response infected cell infected cells Infection killing longitudinal majority memory memory formation memory T memory T cell memory T cells Mild mild case motif Occurrence Participation Phenotypes RepSeq resulting reveal SARS-CoV-2 SARS-CoV-2 coronavirus Sequencing T cell T cells T-cell T-cell receptor T-cell Response TCR TCR sequence TCR sequences the SARS-CoV-2 virus-specific antibodies
[DOI] 10.7554/eLife.63502 PMC 바로가기 [Article Type] Short Report

Spatial and temporal roles of SARS-CoV PL pro -A snapshot

SARS-CoV PL pro -A 스냅샷의 공간적 및 시간적 역할

Review

Published on 2021-01-012022-09-11
Journal: FASEB journal : official publication of the Federa [Category] 치료법,

[키워드] 3CL pro accessory protein accessory proteins Antiviral appear autocleavage C-terminus can not cleave cleaved CoV replication cysteine cysteine protease dilemma domain E3 ubiquitin ligase envelope Factor inhibit inhibitor innate immune response Interaction interferon interferon-stimulated gene ISG15 its target protein its target proteins IκBα membrane motif NF-κB nonstructural protein nsp1 Nsp3 Nsps Nucleocapsid proteins p53 Papain Papain-like protease PLPro polyprotein polyproteins pp1a pp1ab promote protease Protein provide RCHY1 released Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 infections stimulator STING TNF ubiquitin unique Viral Zinc
[DOI] 10.1096/fj.202002271 PMC 바로가기 [Article Type] Review

In silico discovery of antigenic proteins and epitopes of SARS-CoV-2 for the development of a vaccine or a diagnostic approach for COVID-19

COVID-19에 대한 백신 또는 진단 접근법 개발을 위한 SARS-CoV-2 항원 단백질 및 에피토프의 in silico 발견

Article

Published on 2020-12-282022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 변종, 치료기술, 치료법,

[키워드] accessory proteins addition aliphatic index alleles Analysis Antigen antigenic protein antigenic proteins antigens approach assays best Beta can be used cleaved Computational biology and bioinformatics COVID-19 develop diagnostic eight ENCODE envelope epitope Epitopes Features Genome GRAVY GRAVY value highly antigenic immunology in silico Approach membrane protein Membrane proteins MHC-I Microbiology moderate molecular weight motif non-allergic non-structural protein non-structural proteins nucleocapsid protein ORF7a ORF8 peptide polyprotein predicted Protein Proteins SARS-CoV-2 serodiagnostic signal peptide Spike protein structural protein structural proteins surface protein surface proteins transmembrane Vaccine vaccine candidate vaccine candidates variant protein variant proteins was selected Wuhan isolate
[DOI] 10.1038/s41598-020-79645-9 PMC 바로가기 [Article Type] Article

Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding Mortality

Review Article

Published on 2020-12-242022-10-28
Journal: Analytical Cellular Pathology (Amsterdam) [Category] COVID-19, Fulltext, MERS, SARS,

[키워드] affected age BCG vaccination CD4 CD8 Cell contribute COVID-19 Cytotoxic T cell Ethnic groups expressed Factor favor Footprint genetic architecture Health HLA HLA ligand human leukocyte antigen immune response gene Immunity India infected cell infected cells Infection infection rates KIR KIR-HLA landscape Mortality motif natural killer NK cell function Other outbreak overexpressed pandemic polymorphism preventive measure receptor SARS-CoV-2 shown significantly significantly lower survival T cell T cells target the SARS-CoV-2 therapeutic intervention triggering Vaccination strategies virus-infected cell
[DOI] 10.1155/2020/6692739 PMC 바로가기 [Article Type] Review Article

Coronavirus genomes carry the signatures of their habitats

코로나 바이러스 게놈은 서식지의 서명을 가지고 있습니다

Research Article

Published on 2020-12-222022-08-13
Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] abundance Antiviral antiviral protein antiviral proteins Apolipoprotein B avoidance AVP bind Canis coronavirus CoV CpG Degradation dinucleotide effort enzyme evade Evolution Express facilitate generate Genome HIV-1 Homo Homo sapien Homo sapiens Host immune response host immune responses host immune system host tissue Hypothesis immune responses increase in infect infecting Infection Lupus MERS MHV motif mRNA Mus Mutation notable occur Protein residue SAME AS SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 vaccine selective pressure selective pressures sequence Seven Spread Temporal analysis tested the SARS-CoV-2 tissue tissues understanding variations Viral viral genome viral genomes viral transcript viral transcripts ZAP Zinc zinc finger antiviral protein
[DOI] 10.1371/journal.pone.0244025 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors

SARS-CoV-2 에피토프는 인간 T 세포 수용체의 공개적이고 다양한 레퍼토리에 의해 인식됩니다

Article

Published on 2020-12-152022-09-12
Journal: Immunity [Category] MERS, SARS, 진단,

The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles

Research Article

Published on 2020-12-032022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome biochemical C-terminal Cell composed coronavirus COVID-19 COVID-19 pandemic Critical cytoplasmic tail DMEM, Dulbecco’s modified minimal essential medium E, Envelope Endoplasmic reticulum ERGIC ERGIC, endoplasmic reticulum (ER)–Golgi intermediate compartment glycoprotein Golgi highlight IBV, infectious bronchitis virus IF, immunofluorescence induce infected cell Infectious disease Interaction Like M protein M, membrane maturation membrane membrane protein MERS-CoV, Middle East Respiratory Virus modulate modulating motif N-glycosylation N, nucleoprotein other coronaviruses Particle Particles Prevent promote Protein Proteins purified regulate Regulation required S protein S, spike SARS-CoV SARS-CoV-2 SARS-CoV-2 envelope SARS-CoV-2 viral particles SARS-CoV-2-infected cells SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 secretion secretory pathway structural protein syncytia formation the spike protein transfected cells Viral particles Viral protein virus assembly Virus-like particle VLPs, Virus-like particles vRNP, viral ribonucleoprotein β-coronavirus
[DOI] 10.1074/jbc.RA120.016175 PMC 바로가기 [Article Type] Research Article

Acceptabilité du dépistage néonatal de la drépanocytose au cours de la pandémie au COVID-19 à Kisangani, en République Démocratique du Congo

Observational Study

Published on 2020-12-022022-09-01
Journal: The Pan African Medical Journal [Category] MERS, 임상, 진단,

[키워드] acceptabilité acceptability coronavirus COVID-19 dépistage néonatal Drépanocytose DRC hemotypeSC^TM Kisangani motif neonatal screening RDC Sickle cell disease
[DOI] 10.11604/pamj.2020.37.299.26654 PMC 바로가기 [Article Type] Observational Study

The Global and Local Distribution of RNA Structure throughout the SARS-CoV-2 Genome

Genome Replication and Regulation of Viral Gene Expression

Published on 2020-12-022022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] acute respiratory syndrome affected Analysis analyzed approach base pair content cellular coding region comparison complex coronavirus COVID-19 domain domains element exceptional feature functional Genome genomic genomic RNA global pandemic gRNA HCV hepatitis C virus highest in silico knowledge motif Open reading frame ORF ORFs predict predicted provide Region regions resulting RNA RNA genome RNA structure RNA structures RNA transcripts RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA secondary structure sgRNA stability structural stability Structure structured region targets the disease the SARS-CoV-2 unique viral genome viral genomes viral infection Viral RNA viral RNAs while
[DOI] 10.1128/JVI.02190-20 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression