Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein자주 볼 수있는 SARS-COV-2 ORF3A 횡단 단백질의 노출 된 N 및 C 말단 영역을 인식하는 단일 클론 인간 항체Communication Published on 2021-11-022022-09-01 Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단, [키워드] activities activity Analysis anti-ORF3a mAbs antibody antigens apoptosis induction autophagy binding affinities binding affinity C terminal calcium cellular complex conformation COVID-19 infections cytosolic diagnostic Disruption disturbance domain enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes evaluate evaluated Extracellular fluorescent fluorescent microscopy full-length generate homeostasis Human infected cell infected cells inflammasome activation involved linear Microscopy modulate monoclonal antibody N Terminal naïve ORF3a ORF3a protein pathophysiological peptide peptides performed prognostic biomarker Prognostic biomarkers Protein Proteins protocols recombinant antibodies Region SARS-CoV-2 SARS-CoV-2 infected cells selected surface plasmon surface plasmon resonance terminal therapeutic potential transfected cell transmembrane transmembrane protein viroporin western blot [DOI] 10.3390/v13112201 PMC 바로가기 [Article Type] Communication
Identification of nut protein-derived peptides against SARS-CoV-2 spike protein and main proteaseSARS-CoV-2 스파이크 단백질 및 메인 프로테아제에 대한 견과류 단백질 유래 펩타이드 동정Article Published on 2021-11-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료제, [키워드] addition Amino acid amino acid residue amino acid residues assist binding affinities binding affinity binding site coronavirus coronavirus disease COVID-19 COVID-19 patients develop domain effective Entry inhibitor entry inhibitors evaluated exhibited identification in silico inhibitor inhibitor N3 inhibitory M pro molecular docking molecular dynamics Molecular dynamics simulation Novel coronavirus novel coronavirus disease Nut proteins outbreak pandemic peanuts peptide peptides proportions protease Protein RBD reached SARS-CoV-2 SARS-COV-2 M(pro) SARS-CoV-2 main protease SARS-CoV-2 spike protein SARS-CoV-2 Spike RBD SARS-CoV-2 spike RBD. screened Spike protein target the SARS-CoV-2 the spike protein Treatment [DOI] 10.1016/j.compbiomed.2021.104937 PMC 바로가기 [Article Type] Article
Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy항-CD20 요법을 받는 다발성 경화증 환자의 SARS-CoV-2 백신에 대한 체액 및 T 세포 면역 반응 불일치Article Published on 2021-11-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 진단, 치료기술, [키워드] anti-CD20 anti-CD20 therapy array CD20 Cell Community COVID COVID-19 COVID-19 infection determine disease Donor donors generosity Genscript glycoprotein humoral Humoral immunity humoral immunity, multiple sclerosis, anti-CD20 therapies. Humoral response humoral responses IFN-γ IgG immune response immune responses immunoassay impair increase in incubated individual interferon gamma Johns Hopkins Johns Hopkins University linear models Mabtech Medicine mRNA vaccines multiple sclerosis participant PBMC PBMCs peptide peptides Plate receptor reduced Research robust SARS-CoV-2 SARS-CoV-2 vaccination School serum SFC Society Spectrum sphingosine sphingosine-1-phosphate spike glycoprotein subset supported T cell T cell response T cell responses T cells tested Therapies therapy translate [DOI] 10.1016/j.ebiom.2021.103636 PMC 바로가기 [Article Type] Article
Does immune recognition of SARS-CoV2 epitopes vary between different ethnic groups?SARS-CoV2 에피토프의 면역 인식은 인종 그룹마다 다릅니다.Article Published on 2021-11-012022-09-11 Journal: Virus research [Category] SARS, 유전자 메커니즘, [키워드] Affect affecting Alter distribution Effect Efficacy effort elicit epitope Epitope-based vaccine Epitopes Ethnic groups Ethnic variations European Europeans expected Factor HLA HLA allele HLA alleles HLA system Human human leukocyte antigen humans identify immune immune response immunogenic Immunological response impacted less leukocyte manifestation mechanism MHC MHC alleles Mutation pandemic peptide peptides Population populations probe question Recognition recognize Research response Result SARS-CoV2 SARS-CoV2 infection South Asian susceptibility T-cell T-cell Response turn unlikely viral genomes viral infection virus while [DOI] 10.1016/j.virusres.2021.198579 PMC 바로가기 [Article Type] Article
Mass spectrometric identification of immunogenic SARS-CoV-2 epitopes and cognate TCRs면역원성 SARS-CoV-2 에피토프 및 동족 TCR의 질량 분석 식별420 Published on 2021-11-012022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach best binding affinities caused cell lines cells cellular immune responses conserved coronavirus COVID-19 COVID-19 infection Critical defined effective elicit epitope Epitopes Evidence expressing glycoprotein histocompatibility complex humoral Humoral response humoral responses immune immune protection immune responses immunogenic immunogenicity In silico method in vitro increasingly Infection infectious kill killing major histocompatibility complex malignant disease malignant diseases mass spectrometric mass spectrometry membrane membrane glycoprotein MGP MHC MHC peptide nsp13 peptide peptides predict processed Protein recognize recognizing Region reported respiratory robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2 peptide SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance specificity T cell T cell epitope T cell epitopes T cell response T cell responses T cells tandem Tandem mass spectrometry target cells TCR TCR-T the disease the SARS-CoV-2 therapy to define Treatment variants [DOI] 10.1073/pnas.2111815118 PMC 바로가기 [Article Type] 420
Vasoactive Peptides: Role in COVID-19 Pathogenesis and Potential Use as Biomarkers and Therapeutic Targets혈관 활성 펩티드: COVID-19 발병의 역할 및 바이오마커 및 치료 표적으로서의 잠재적 사용Review Published on 2021-11-012022-09-11 Journal: Archives of medical research [Category] MERS, SARS, 바이오마커, 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Ang II angiotensin Angiotensin II Biomarker Biomarkers bradykinin calcitonin calcitonin gene-related peptide cause coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient develop Effect Endothelin Endothelin-1 ET-1 global health Health Healthcare system intestinal management observation outbreak pathological conditions Patient peptide peptides physiological Potential potential therapeutic target potential therapeutic targets prognostic indicator respiratory Respiratory complications role SARS-CoV-2 severe acute respiratory syndrome Coronavirus substance P target the disease therapeutic target therapeutic targets Vasoactive vasoactive intestinal peptide Vasoactive peptides. VIP [DOI] 10.1016/j.arcmed.2021.05.007 PMC 바로가기 [Article Type] Review
Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronavirusesSARS-CoV-2에 대한 기존 T 세포 매개 교차 반응성은 고유한 인간 코로나바이러스에 대한 사전 노출만으로는 설명할 수 없습니다Article Published on 2021-11-012022-09-12 Journal: Infection, genetics and evolution : journal of mol [Category] MERS, SARS, 진단, [키워드] Antigen can not common cold core genes Coronaviridae Coronaviridae family coronavirus cross-reactive cross-reactivity dataset endemic human coronavirus epitope Epitopes expected explain explained exposure to family Coronaviridae Genetic had no HCoVs Highlights homology individual Pearson peptide peptides Phylogenetic Phylogeny pre-existing immunity profiles proportion Protein proteome random reconstructed reported SARS-CoV-2 sequence sequence homology similarity suggested T-cell T-cell epitope T-cell-mediated immunity tested the Coronaviridae [DOI] 10.1016/j.meegid.2021.105075 PMC 바로가기 [Article Type] Article
Gamma Delta T Cells and Their Involvement in COVID-19 Virus InfectionsImmunology Published on 2021-10-292022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation affected Antigen appear Cancer therapy caused children classical COVID-19 COVID-19 patient decrease Delta disease Express Gamma gamma-delta T cell human cells immune response immunize in vitro infected cell infected cells Infection Inflammation innate immune system involved Involvement kill lockdowns lymphopenia MHC microbe oncology outbreak Patient peptides present antigen Research respond SARS-CoV-2 subset Symptom T cell T cell subset T cells T-cells the disease Vaccine viral antigens viral infection virus while [DOI] 10.3389/fimmu.2021.741218 PMC 바로가기 [Article Type] Immunology
Ezrin Peptide Therapy from HIV to COVID: Inhibition of Inflammation and Amplification of Adaptive Anti-Viral ImmunityHIV에서 COVID로의 Ezrin Peptide Therapy: 염증 억제 및 적응형 항바이러스 면역의 증폭Review Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activate adaptive adjuvant adjuvants Administered amino acids Anti-viral immunity antibody antibody titres B cell candidiasis chronic diarrhea Clinical studies clinical study Colon COVID Cytokines derivative diarrhea disappearance disease domain duodenum dysregulation effective ENhance enhancer enhancers Enterocolitis expression ezrin ezrin peptides FIVE gp120 HCV herpes herpes zoster HIV HIV-infected patients homologous HPV Human human respiratory viruses IL-6 immune responses Immunity Inflammation inflammatory complications Inflammatory cytokines Influenza Inhaled inhibition inhibitor inhibitors innate immune response innate immune responses mice Microbiome middle Mild-to-moderate mucosal Mutation normalization opportunistic infection opportunistic Infections outbreak peptide peptides Placebo Prevent produced Protein randomised receptor Registered replicated respiratory respiratory viruses resulting Russia SARS-CoV-2 SARS-COV-2 infection shown stomach synthetic synthetic peptides T cell therapy tissue repair treat Treatment ulceration vaccination Viral viral respiratory virus virus infection viruses Volunteer [DOI] 10.3390/ijms222111688 PMC 바로가기 [Article Type] Review
Whey-Derived Peptides at the Heart of the COVID-19 PandemicCOVID-19 팬데믹의 중심에 있는 유청 유래 펩타이드Article Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] ACE ACE inhibitor ACE inhibitors ACE inhibitory activity ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach association blood pressure blood pressure homeostasis Captopril cells component coronavirus COVID-19 COVID-19 pandemic drugs dual enzyme exhibiting heart human ACE2 hypertension inhibit inhibitory inhibitory action inhibitory activity IPP Lisinopril molecular docking molecular interaction peptide peptide sequences peptides Previous studies produced RAS RAS inhibitor RAS inhibitors receptor reduced risk renin–angiotensin system renin–angiotensin system reported respiratory SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus shown synthetic drugs therapeutic Treatment treatment of COVID-19 were assessed whey peptides [DOI] 10.3390/ijms222111662 PMC 바로가기 [Article Type] Article