A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection바이러스 유래 마이크로 RNA는 SARS-CoV-2 감염 시 면역 반응 유전자를 표적으로 한다Article Published on 2021-12-162022-09-10 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3′UTR Argonaute conserved COVID‐19 COVID‐19 patients COVID‐19 cultured cells Dicer enzyme evade expression help Host Host immune response host immune responses host miRNA human cell identify immune response immune response gene immune response genes immune responses infected cell infected cells innate immune response interfere interferon interferon response isoform Microbiology, Virology & Host Pathogen Interaction microRNA miRNA miRNAs Nasopharyngeal swab nasopharyngeal swabs Patient predominant Proteins repress represse RNA Biology SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 sequence small RNA Small RNAs target transcript Viral viral genome viral miRNA [DOI] 10.15252/embr.202154341 PMC 바로가기 [Article Type] Article
First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in SpainSARS-COV-2 델타 (B.1.617.2) 스페인의 임상 징후를 가진 개에서의 우려 변형의 첫 번째 탐지Case Reports Published on 2021-12-162022-09-01 Journal: Viruses [Category] Fulltext, SARS, 변종, 조류인플루엔자, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal B.1.617.2 caused clinical Clinical sign Clinical signs collected concern coronavirus COVID-19 Delta delta variant detection digestive dog indicated Infection Infectious disease Mild Neutralizing antibodies neutralizing antibody oropharyngeal swab pandemic pets predominant reported reservoir reservoirs respiratory reverse zoonosis SARS-CoV-2 SARS-CoV-2 variants Sequencing seroconverted severe acute respiratory syndrome Coronavirus SIGN Spain susceptibility Transmission variant variants of concern Viral Viral load VoC whole-genome sequencing [DOI] 10.3390/v13122526 PMC 바로가기 [Article Type] Case Reports
mUzima Mobile Electronic Health Record (EHR) System: Development and Implementation at ScaleOriginal Paper Published on 2021-12-142022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] approach atlas Cancer Care chronic disease Cohort Community conditions country COVID-19 developing countries development Digital digital divide Digital health domains EHR EHR system electrical electronic medical records element Evidence evidenced exacerbate extension feature Features global health Health health information highlight HIV implementation IMPROVE Intervention Kenya management media meet Mobile Mobile health objective patient data predominant principle provided Record Result robust scale scaled Support supported the WHO Uganda was used WHO WHO’ World Health Organization [DOI] 10.2196/26381 PMC 바로가기 [Article Type] Original Paper
Immunoinformatics Analysis of SARS-CoV-2 ORF1ab Polyproteins to Identify Promiscuous and Highly Conserved T-Cell Epitopes to Formulate Vaccine for Indonesia and the World PopulationArticle Published on 2021-12-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Algorithms allele Antigen caused class conserved contribute Coverage COVID-19 pandemic criteria CTL cytotoxic T-cells docking epitope epitope mapping FIVE helper T-cells HLA HLA-A*24:07 HTL human leukocyte antigen IFNγ immunoinformatics in vitro study Indonesia Infection leukocyte linkers Microbiome multi-epitope peptide-based vaccine ORF1ab peptide peptides physicochemical characteristics Population predominant Protective reducing reflected Region responses SARS-CoV-2 shown stimulate Symptom T-cell T-cell epitopes T-cell Response the vaccine TLR4 toll-like receptor 4 vaccine construct Vaccine design variant β-defensin [DOI] 10.3390/vaccines9121459 PMC 바로가기 [Article Type] Article
No evidence of SARS-CoV-2 in hospitalized patients with severe acute respiratory syndrome in five Italian hospitals from 1 st November 2019 to 29 th February 2020Research Article Published on 2021-12-072022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] acute respiratory illness acute respiratory syndrome affected ARI China CDC circulation Clinical characteristics collected conducted coronavirus disease country COVID-19 detect determine development enrolled epidemiological Epidemiology evaluate Evidence FIVE Healthcare system highest highlight hospital hospitalized patient identify identifying incidence rate Influenza influenza A virus influenza B influenza viruses information Italian Italy majority mapping the spread material molecular multiplex no evidence of Novel coronavirus objective Oropharyngeal pandemic Patient Phase I positive predominant prevalent regions Registered reported respiratory Result retrospective Sample SARS-CoV-2 SARS-COV-2 infection shown Study protocol Swab tested virus viruses [DOI] 10.1371/journal.pone.0260947 PMC 바로가기 [Article Type] Research Article
Patient health records and whole viral genomes from an early SARS-CoV-2 outbreak in a Quebec hospital reveal features associated with favorable outcomesResearch Article Published on 2021-12-022022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis association clinical feature clinical outcomes COVID-19 data-driven early stage feature genomic headache Health hospital hospitals Lineage Local Mutation myalgia Nanopore Nasopharyngeal swab occurred outbreak outcome outcomes pandemic pangolin Patient performed positive sample predominant Protein Quebec, Canada reduction replicates SARS-CoV-2 Sequencing significantly sore throat subclade Symptom the Spike Transmission viral genome whole genome [DOI] 10.1371/journal.pone.0260714 PMC 바로가기 [Article Type] Research Article
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein천연물 화합물은 보존된 Nsp9 SARS-CoV-2 단백질에 결합하여 시험관 내 코로나바이러스 복제를 억제합니다Article Published on 2021-12-012022-09-11 Journal: The Journal of Biological Chemistry [Category] SARS, 치료제, [키워드] affinities antiviral activity Antiviral compound approach assays bind binding C-terminal cellular complex Compound conserved Coronaviral crystal structure cytotoxic domain dose facilitate in vitro Infection inhibit kaurane MERS-CoV molecular Nsp12 Nsp9 oridonin predominant preliminary finding Protein purified reduce reducing Replication replication transcription complex. SARS-CoV-2 SARS-CoV-2 protein substrate Transcription viral titer [DOI] 10.1016/j.jbc.2021.101362 PMC 바로가기 [Article Type] Article
Prevalence, co-infection and seasonality of fecal enteropathogens from diarrheic cats in the Republic of Korea (2016–2019): a retrospective studyResearch Published on 2021-12-012022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] accounted addition age Bacterial infection Campylobacter caused Clinical characteristics Clinical features Clostridium Co-infection collected common clinical symptom coronavirus diarrhea distribution fecal feline Foetus Infection infection rate infections investigated pathogen Patient peaked positive predominant Prevalence Real-time PCR required Result Retrospective study viral infection [DOI] 10.1186/s12917-021-03075-6 PMC 바로가기 [Article Type] Research
Introduction and rapid dissemination of SARS-CoV-2 Gamma Variant of Concern in Venezuela베네수엘라에서 우려의 SARS-CoV-2 감마 변종 도입 및 급속 확산Article Published on 2021-12-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 치료기술, [키워드] accumulated addition adopted antibody approach association Complete concern country COVID-19 dissemination dominant variant E484K E484K mutation East fragment of Frequency Gamma Genome sequencing genomic Genomic surveillance GISAID identify isolate less lineages MONITOR Mutation mutations neutralization New coronavirus predominant Protein Rapid Rapid screening Reinfection representing responsible robust SARS-CoV-2 sequence sequenced sequences shown Spike protein Surveillance the Spike Transmissibility variant variants variants of concern Venezuela viral genome Viral variants virus VoC VOCs WHO [DOI] 10.1016/j.meegid.2021.105147 PMC 바로가기 [Article Type] Article
Heart Failure Probability and Early Outcomes of Critically Ill Patients With COVID-19: A Prospective, Multicenter StudyCardiovascular Medicine Published on 2021-11-262022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 95% CI age albumin all-cause mortality analyzed applied assist bootstrap C-index cardiac function clinical suspicion coronavirus disease COVID-19 Critically ill patient enrolled failure Follow-up heart heart failure highlighting Ill IMPROVE In-hospital death laboratory-confirmed lymphocyte Mortality mortality rate multicenter multicenter study multivariate logistic regression nomogram NT-proBNP operator outcome Patient patients died predict Predictive predominant Primary outcome Probability Prognosis Prospective Prospective Study risk factor risk stratification screened significantly higher the patient total bilirubin unlikely with COVID-19 zone [DOI] 10.3389/fcvm.2021.738814 PMC 바로가기 [Article Type] Cardiovascular Medicine