Tracking the introduction and spread of SARS-CoV-2 in coastal Kenya케냐 해안에서 SARS-CoV-2의 도입 및 확산 추적Article Published on 2021-08-102022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 치료기술, [키워드] accounted B.1 collected country early stage early stages Epidemic Epidemiology European Evidence evidence of Genomic surveillance independent individual initial International introduced Kenya Lineage lineage B.1 lineages Local phylogenetics Phylogenomics Phylogeny prevented Public health response SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes screened sequenced Spread the epidemic Transmission viral infection [DOI] 10.1038/s41467-021-25137-x PMC 바로가기 [Article Type] Article
IL-13 is a driver of COVID-19 severityIL-13은 COVID-19 심각성의 동인입니다Research Article Published on 2021-08-092022-09-10 Journal: JCI Insight [Category] MERS, SARS, 유전자 메커니즘, [키워드] accumulation addition administration block blockade CD44 characteristic contribute COVID-19 COVID-19 severity cytokine Cytokines death disease severity downregulated gene Dupilumab dysregulation elevated Has1 highlighting Hyaluronan IL-13 IL-4 immune dysregulation immune system immunology implication independent Innate immunity less lung Lung disease Lungs mAb mechanical ventilation mechanism mediator mice Mortality mouse model neutralization open pathogenic Patient patient cohorts patients with COVID-19 plasma polysaccharide prevented pulmonary diseases Pulmonary pathology receptor reduced SARS-COV-2 infection SARS-CoV-2–infected mice severe COVID-19 severe disease Signaling Stage Th2 response the disease therapy Treatment understanding Viral Viral load was increased without affecting [DOI] 10.1172/jci.insight.150107 PMC 바로가기 [Article Type] Research Article
Lacticaseibacillus paracasei DG enhances the lactoferrin anti-SARS-CoV-2 response in Caco-2 cellsLacticaseibacillus paracasei DG는 Caco-2 세포에서 락토페린 항-SARS-CoV-2 반응을 향상시킵니다Brief Report Published on 2021-08-072022-09-11 Journal: Gut Microbes [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral immunity Caco-2 Caco-2 cell cell line Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 distress ENhance epithelial epithelial cells exhibit expression expression of gene gastrointestinal tract global pandemic immune immunomodulatory effect immunomodulatory effects in vitro inhibited intestinal intestinal epithelial cells investigated involved lactobacilli lactoferrin lead microorganism microorganisms prevented Probiotics proinflammatory gene proinflammatory genes Prophylactic Protective respiratory respiratory distress SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro shown significantly Strains Symptom triggered [DOI] 10.1080/19490976.2021.1961970 PMC 바로가기 [Article Type] Brief Report
Osteomyelitis variolosa, an issue inherited from the past: case report and systematic reviewReview Published on 2021-08-062022-10-29 Journal: Orphanet Journal of Rare Diseases [Category] COVID-19, [키워드] accounted Arthritis Case report clinician Complication complications contracture cured Diagnosis diagnostic disease Endemic fixation flexion Google Scholar India joint lesion Osteomyelitis Osteomyelitis variolosa Patient patients physician Physicians prevented Quality of life receive Result searched self-limiting disease skeletal smallpox surgical systematic review Treatment triggered variola virus Web of Science [DOI] 10.1186/s13023-021-01985-0 PMC 바로가기 [Article Type] Review
Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas protegens슈도모나스 단백질 겐에서 표현형 및 유전 적 결과의 예측Research Article Published on 2021-08-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation adaptive addition Air-liquid interface Amino acid Bacterial Biological Biology can not Cancer Cellulose changed Climate change colonize condition conditions conserved core dependent on develop Diseases disrupt Evolution expected experiments Factor fitness followed by Forecasting Genetic Genotype growth hot spot identity Infectious diseases lack majority mathematical mathematical model microbe microbes model system model systems MOST motility mutant mutants Mutation mutation rate Mutation rates mutations negative regulation nucleotide outcome outcomes pathway phenotype Phenotypes phenotypic polysaccharide Population predict predictability predicted predicted gene predicted genes Predictive model prevented problems promoter regions Protein provide Pseudomona Pseudomonas Pseudomonas species Pseudomonas specy real time reduced Region resulting sequence tested Variation [DOI] 10.1371/journal.pgen.1009722 PMC 바로가기 [Article Type] Research Article
The Effects of Aβ 1-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2Article Published on 2021-07-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Aβ ACE2 acute respiratory syndrome Alzheimer’s disease Alzheimer’s disease angiotensin-converting enzyme 2 antibody binding Blood C-terminal clearance coronavirus Course COVID-19 Dementia domain Effect elevated Evidence Extracellular high affinity IL-6 Increasing intravenous mechanism prevented progression receptor reducing residue S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein severe coronavirus disease severity spike the SARS-CoV-2 the spike protein trimer viral entry Viral protein [DOI] 10.3390/ijms22158226 PMC 바로가기 [Article Type] Article
COVID-19 vaccines that reduce symptoms but do not block infection need higher coverage and faster rollout to achieve population impactArticle Published on 2021-07-302022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] Applied mathematics assumed asymptomatic infections benefit calibrated Combination Coverage COVID-19 disease COVID-19 vaccine criteria cumulative death decrease Efficacy expected faster greater Hospitalization Infection infections King mathematical Prevent prevented profile reduce reduction reported resulting SARS-COV-2 infection SARS-CoV-2 transmission spring susceptibility Symptom symptomatic disease symptomatic infection Symptoms Transmission vaccination Vaccine viral infection Washington [DOI] 10.1038/s41598-021-94719-y PMC 바로가기 [Article Type] Article
Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation StrategiesReview Published on 2021-07-212022-10-28 Journal: Biomolecules [Category] COVID-19, [키워드] advance alternative platform Antigen Bacterial costly death disease Diseases effective strategy Efficacy Escherichia coli faster Genetic hosts improvement inactivated Inactivated Vaccines Infectious disease mammalian cells offer Pandemics pathogenic Pathogens plant prevented Production protein expression system recombinant antigen recombinant subunit vaccines recombinant vaccine reduce Saccharomyces cerevisiae Strategy subunit subunit vaccines time-consuming Traditional Treatment vaccination Vaccine Vaccine design VLP weaker immune response yeast [DOI] 10.3390/biom11081072 PMC 바로가기 [Article Type] Review
Novel coronavirus 2019-nCoV (COVID-19): early estimation of epidemiological parameters and epidemic size estimatesArticles Published on 2021-07-192022-10-29 Journal: Philosophical Transactions of the Royal Society B: [Category] COVID-19, SARS, [키워드] 2019-nCoV 95% CI arising ascertainment rate basic reproductive number case ascertainment China coronavirus country COVID-19 pandemic Epidemic epidemiological estimate greater Infection information international travel novel Novel coronavirus pandemic parameter prevented regions SARS-CoV-2 significantly the epidemic Transmission Transmission model Wuhan Wuhan, China [DOI] 10.1098/rstb.2020.0265 PMC 바로가기 [Article Type] Articles
The population attributable fraction of cases due to gatherings and groups with relevance to COVID-19 mitigation strategiesArticles Published on 2021-07-192022-10-29 Journal: Philosophical Transactions of the Royal Society B: [Category] COVID-19, SARS, [키워드] 95% confidence interval accounted asked basic reproduction number caused Contact coronavirus country COVID-19 COVID-19 mitigation COVID-19 pandemic Epidemic epidemiological events fraction gatherings group individual outbreak PAF pandemic population attributable fraction (PAF) prevented reported SARS-CoV-2 social contact Transmission used data [DOI] 10.1098/rstb.2020.0273 PMC 바로가기 [Article Type] Articles