Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant혈통 A SARS-CoV-2 변이체를 사용한 이전 에어로졸 감염은 햄스터를 질병으로부터 보호하지만 B.1.351 SARS-CoV-2 변이체에 의한 재감염은 보호하지 않습니다.Research Article Published on 2021-06-262022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] aerosol aerosol exposure anamnestic response B.1.351 caused circulation Contact direct contact disease exposure to fomite hamster hamsters HCoV HCoV-19 Heterologous humoral induce Infection Infection route infection with SARS-CoV-2 Infectious virus initial intranasal Lineage lose weight low dose Lungs majority mild infection naïve neutralization neutralize Neutralizing onward transmission pathology Prevent PROTECT protective immunity provide Pulmonary pathology Reinfection remained Replication SARS-CoV-2 SARS-CoV-2 variant seroconverted Syrian hamster These data titre titres Transmission triggered variants variants of concern virus VoC VOCs WA1 weight weight loss [DOI] 10.1080/22221751.2021.1943539 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lungAlum-3M-052가 보강된 SARS-CoV-2 RBD 삼량체 단백질은 폐의 SARS-CoV-2 감염 및 면역 병리로부터 보호합니다Article Published on 2021-06-112022-09-12 Journal: Nature Communications [Category] MERS, SARS, 진단, [키워드] alum Antibody Response Antibody titer Antigen cause changes in disease dose efficient ENhance function immune induce Infection inhibit innate cell Live virus long-lasting Longevity lung Lung pathology mice monomer Neutralizing antibodies Neutralizing antibody response Neutralizing antibody titer non-human primate non-human primates pathology potency PROTECT protective immunity Protein Protein vaccines provide RBD Receptor binding domain Receptor-binding domain rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD trimer SARS-CoV-2 spike Spike protein the antibody response the RBD the receptor-binding domain the spike protein TLR7 TLR7/8 trimer trimeric vaccination Vaccine viral infection [DOI] 10.1038/s41467-021-23942-y PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus 2 escape mutants and protective immunity from natural infections or immunizations중증급성호흡기증후군 코로나바이러스 2 탈출 돌연변이 및 자연 감염 또는 예방접종으로부터의 보호 면역Review Published on 2021-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] SARS, 변종, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus coronavirus disease Coronavirus disease 2019 disease escape escape mutant escape mutants Immunity immunization natural infection protective immunity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Vaccine [DOI] 10.1016/j.cmi.2021.03.011 PMC 바로가기 [Article Type] Review
Insights into SARS-CoV-2 Persistence and Its RelevanceReview Published on 2021-05-292022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute infections acute respiratory syndrome Asymptomatic Basic science Care coronavirus coronavirus disease Coronaviruses COVID-19 disease pathogenesis effective effort Evolution globe highlight Host hotspot Immune status insight Isolation literature review Long COVID mechanism mild SARS-CoV-2 infection pandemic PASC persistence protective immunity public health Public health response rehabilitation Reinfection Relevance Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Spread Survivors the SARS-CoV-2 understanding viral persistence viral replication viral shedding [DOI] 10.3390/v13061025 PMC 바로가기 [Article Type] Review
DNA vaccination induced protective immunity against SARS CoV-2 infection in hamsterssResearch Article Published on 2021-05-272022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome analyses analyzed antibody antigen-specific antibody approach binding blocked cloned collected coronavirus COVID-19 COVID-19 epidemic COVID-19 pandemic COVID-19 vaccine demonstrated DNA DNA vaccine Efficacy Electroporation elicited entry receptor expression expression vectors global public health hamster hamsters Health HEK293T cells humoral immune response immunization in vivo inactivated induce Infection levels of antibody long-lasting mammalian cell neutralizing antibody Neutralizing antibody titer outbreak pandemic Protective protective effect protective immunity Protein respond SARS CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 vaccine sera serum antibody Side effects spike gene Spike protein Spike protein expression suggested T cell response Th1 Th1-biased immune response the receptor-binding domain the SARS-CoV-2 transient expression vaccination Vaccine virus [DOI] 10.1371/journal.pntd.0009374 PMC 바로가기 [Article Type] Research Article
Maintenance of neutralizing antibodies over ten months in convalescent SARS‐CoV‐2 afflicted patients회복기 SARS-CoV-2 환자에서 중화항체를 10개월 이상 유지Original Article Published on 2021-05-272022-09-01 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analysed Antibody titre approaches chemiluminescent immunoassay convalescent convalescent individual convalescent individuals data interpretation develop Evidence finding humoral immune response IgG antibodies immune responses Immunity immunofluorescence assay individual Infection investigated lack maintain maintenance Neutralization assay neutralization test Neutralizing antibodies neutralizing antibody Patient persistence positive correlation Primary infection Protective protective immunity SARS‐CoV‐2 SARS‐CoV‐2 Severity of infection specific antibodies [DOI] 10.1111/tbed.14130 PMC 바로가기 [Article Type] Original Article
Repeated Exposure to Subinfectious Doses of SARS-CoV-2 May Promote T Cell Immunity and Protection against Severe COVID-19SARS-CoV-2의 하위 감염 용량에 대한 반복적인 노출은 T 세포 면역 및 심각한 COVID-19에 대한 보호를 촉진할 수 있습니다Opinion Published on 2021-05-222022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] absence COVID-19 COVID-19 infection COVID-19 infections detrimental disease severity dose environmental exposure Europe European country exposure to facial masking Factor Factors fomites heterogeneous Hospitalization immune immune protection immunization increasingly induce Inflammation Intervention intestinal tract long term low-dose memory T cells Mortality observation pandemic positive protection protective immunity provided reducing respiratory resulting SARS-CoV-2 SARS-CoV-2 dynamics SARS-CoV-2 particles SARS-CoV-2 variants SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells severe COVID-19 short term Spread starting suggested T cell T cell memory T cell responses T cells transmissible variant vaccination Vaccinations Viral viral particle virus widespread [DOI] 10.3390/v13060961 PMC 바로가기 [Article Type] Opinion
Circulating CD4 T Cells Elicited by Endemic Coronaviruses Display Vast Disparities in Abundance and Functional Potential Linked to Antigen Specificity and Age풍토성 코로나바이러스에 의해 유도된 순환하는 CD4 T 세포는 항원 특이성 및 연령과 관련된 풍부함 및 기능적 잠재력에 있어 큰 격차를 나타냅니다.Article Published on 2021-05-202022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료법, [키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age CD4 CD4 T cell CD4 T cells Cell Cell-mediated immunity circulating collected comparable coronavirus cross-reactive disparity display endemic human coronavirus endemic human coronaviruses epitope Epitopes evaluated examined functional granzyme granzyme B HCoV Infection Influenza interferon interferon-γ interleukin interleukin-2 lack long-lasting memory cell Memory cells nucleocapsid Potential protective immunity reactivity recruited recruitment response robust SARS-CoV infection SARS-CoV infections SARS-CoV-2 SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus specificity Spike proteins Stimulation subject subjects T cells thought Vaccinations Viral antigen [DOI] 10.1093/infdis/jiab076 PMC 바로가기 [Article Type] Article
Dynamics of neutralizing antibody responses to SARS-CoV-2 in patients with COVID-19: an observational studyCOVID-19 환자에서 SARS-CoV-2에 대한 중화 항체 반응의 역학: 관찰 연구Clinical Trial Published on 2021-05-182022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 임상, 진단, 치료기술, [키워드] age albumin antibody-based therapy caution China Cohort correlated COVID-19 COVID-19 patient decay declined Dilution disease severity Dynamics enrolled feasibility FRNT half-time infected individual Infection Infectious diseases median time Mild NAb NAbs neutralization neutralization test Neutralizing activity neutralizing antibody Neutralizing antibody response observation onset of symptoms Patient peaked positive positively correlated protective immunity reached remained SARS-CoV-2 Seroconversion serum albumin severity of COVID-19 surrogate virus neutralization test sVNT Vaccine validation study virus neutralization test [DOI] 10.1038/s41392-021-00611-6 PMC 바로가기 [Article Type] Clinical Trial
Estimation of Transmission of COVID-19 in Simulated Nursing Homes With Frequent Testing and Immunity-Based Staffing빈번한 검사와 면역 기반 인력을 갖춘 모의 요양원에서의 COVID-19 전파 추정Research Published on 2021-05-142022-09-10 Journal: JAMA Network Open [Category] 치료제, [키워드] absence agent analyzed Antigen assigned association assumed Care Chain Reaction Cohort Community conducted Contact COVID-19 COVID-19 cohort COVID-19 diagnosis COVID-19 pandemic COVID-19 transmission cumulative cumulative incidence Estimated estimation evaluate exposure feasible Final finding fraction Frequency home immune impacted Importance incidence infected with SARS-CoV-2 Infection Intervention Long-term care measure Nursing nursing home nursing homes objective outbreak participant Personal protective equipment Point polymerase chain polymerase chain reaction populations Prevalence proportion PROTECT protective immunity reduce reduced reducing reduction in Relevance replaced resident Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 transmission screening test screening tests setting Spread Strategy susceptible Testing the mean Transmission transmission of SARS-CoV-2 uninfected vulnerable population with COVID-19 [DOI] 10.1001/jamanetworkopen.2021.10071 PMC 바로가기 [Article Type] Research