Potential Anionic Substances Binding to Platelet Factor 4 in Vaccine-Induced Thrombotic Thrombocytopenia of ChAdOx1-S Vaccine for SARS-CoV-2Immunology Published on 2022-01-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Adenovirus Analysis anionic anionic substances antibodies Antigen association autoantibody ChAdOx1-S ChAdOx1-S vaccine characterized component DNA Express expressed Factor FIVE glycoprotein PF4 Potential Protein Proteins recent SARS-CoV-2 substance susceptible individual the S protein the vaccine thrombocytopenia thrombosis thrombotic triggered tween vaccination Vaccine vaccine-induced thrombotic thrombocytopenia (VITT) Venous thrombosis [DOI] 10.3389/fimmu.2021.782335 PMC 바로가기 [Article Type] Immunology
Syncytin, envelope protein of human endogenous retrovirus (HERV): no longer ‘fossil’ in human genomeReview Published on 2022-01-122022-10-28 Journal: Animal Cells and Systems [Category] COVID-19, [키워드] acute respiratory syndrome arising Cancer caused coding coronavirus COVID-19 COVID-19 disease developmental Diseases Env envelope protein Evolution exogenous retrovirus expressed HERV HERVs Human Human genome Infection mental symptoms molecular Neurodegenerative disease Neurological diseases Pathologies Placenta Proteins reported retroviral retrovirus SARS-CoV-2 similarity syncytin the spike protein transcript Viral particles [DOI] 10.1080/19768354.2021.2019109 PMC 바로가기 [Article Type] Review
SBSA: an online service for somatic binding sequence annotationSBSA: 체세포 결합 시퀀스 주석을 위한 온라인 서비스Article Published on 2022-01-112022-09-11 Journal: Nucleic Acids Research [Category] 변종, 유전자 메커니즘, [키워드] alteration approach binding Cancer cells candidate cause demonstrated efficient ETS1 Genome genomic variant genomic variants help hypotheses identify joint mechanism miRNA molecular Mutation nucleotide offer online tool Organisms polymorphism promoter region Proteins reference genome RNA sequence sequences single nucleotide Single nucleotide polymorphism Somatic somatic mutation subjects Support TERT TFS therapeutic transcription factor transcription factors variants [DOI] 10.1093/nar/gkab877 PMC 바로가기 [Article Type] Article
The 2022 Nucleic Acids Research database issue and the online molecular biology database collectionAcademicSubjects/SCI00010 Published on 2022-01-072022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, SARS, [키워드] acid article Atla Biology CAZy Collection ConsensusPathDB COVID-19 database described Genomics Human include issue Major manuscript metabolism microbial Molecular biology New notable nucleic acid post-translational modifications Protein Proteins resource resources SARS-CoV-2 Structure target UCSC Genome Browser viral genome website [DOI] 10.1093/nar/gkab1195 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials2022년 약리학에 대한 IUPHAR/BPS 가이드: COVID-19, 말라리아 및 항균제에 대한 약리학 큐레이팅AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] 말라리아, 치료제, [키워드] adverse effect adverse effects Antibiotic resistance block viral entry Community content coronavirus Coverage COVID-19 COVID-19 pandemic database drug target expansion global health guide Health Host include Infection Ligand ligands malaria Medicine Medicines molecular interaction nine partnership patients with COVID-19 Pharmacology Proteins reduce Release Research SARS-CoV-2 Support target targets Viral viral entry [DOI] 10.1093/nar/gkab1010 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Prediction of the effects of the top 10 nonsynonymous variants from 30229 SARS-CoV-2 strains on their proteins30229 SARS-CoV-2 균주의 상위 10개 동의어가 아닌 변이체가 단백질에 미치는 영향 예측Article Published on 2022-01-062022-09-11 Journal: F1000Research [Category] SARS, 변종, [키워드] addition affecting Amino acid amino acid residue Analysis analyzed bioinformatics cause co-mutation computational studies Computational study consequence COVID-19 D614G Deleterious Effect Frequency functions highest Impact in vitro in vivo Multiple studies Mutation N protein N501Y nine nonsynonymous mutation nonsynonymous mutation. Nonsynonymous mutations nonsynonymous variant Nsp12 nsp5 ORF1 ORF1a ORF1b ORF3 ORF3a outbreak P323L pathogen prediction Protein protein structure Proteins Q57H reported S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequences SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 strain SARS-CoV-2 virus stability Structure the SARS-CoV-2 genome wild type Wuhan Wuhan, China [DOI] 10.12688/f1000research.72904.2 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy ImpairmentMicrobiology Published on 2022-01-062022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome binding cause caused cells co-immunoprecipitation Coronavirus-2 Critical cross cyclosporin A Defense dsRNA early stage energy metabolism expression fluorescent homeostasis host cell increase in inhibited initiated innate immune response Interaction involved knockdown Microscopy Mitochondria mitochondrial mitochondrial accumulation mitochondrial dysfunction mitochondrial membrane mitophagy performed Proteins Quality control reactive oxygen specy recruitment reduced RNA ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selective substrate Tom20 Viral load viral RNA localization virus clearance [DOI] 10.3389/fmicb.2021.780768 PMC 바로가기 [Article Type] Microbiology
Cardiovascular Risk After SARS-CoV-2 Infection Is Mediated by IL18/IL18R1/HIF-1 Signaling Pathway AxisSARS-CoV-2 감염 후 심혈관 위험은 IL18/IL18R1/HIF-1 신호 경로 축에 의해 매개됩니다Immunology Published on 2022-01-052022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] activate activated Activation Algorithm Analysis Aneurysm aneurysms Atherosclerosis axis cardiovascular cardiovascular risk Cell cell types changes in characterized choice Compound COVID-19 COVID-19 infection detect Epigenetic expected functional gene co-expression network HIF-1 HIF-1 signaling pathway HIF1a hypoxia identify IL-18 IL18 IL18R1 Infection Inference Intercellular communication interleukin locus Macrophage macrophages MAP2K1 mechanism Mediated MEK inhibitor Methylation NF-κB nucleus objective pathway Pathways PBMC phenotype phenotypic Potential promote promoted Proteins Proteomic analysis Regulation Regulatory Regulon Result SARS-CoV-2 SARS-COV-2 infection scRNA-seq Signaling signaling pathway smooth muscle therapeutic compound therapeutic target Treatment type I interferon type I interferon pathway vascular smooth muscle vascular smooth muscle cells VIPER was used WGCNA with COVID-19 [DOI] 10.3389/fimmu.2021.780804 PMC 바로가기 [Article Type] Immunology
Hypozincemia in COVID-19 Patients Correlates With Stronger Antibody ResponseCOVID-19 환자의 저아연혈증은 더 강력한 항체 반응과 상관관계가 있습니다Immunology Published on 2022-01-042022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] age anti-inflammatory activity antibody Antibody Response antibody response against Antiviral circulating close contact cofactor Concentration coronavirus coronavirus 2 Coronavirus disease 2019 correlation COVID - 19 COVID-19 COVID-19 patient COVID-19 patients domain enzyme evaluate exhibit healthy subject healthy subjects healthy volunteer IgG Infection IQR levels of antibodies levels of antibody nucleocapsid protein outcome Patient patients with COVID-19 Proteins RBD receptor Receptor-binding domain remained respiratory response Result SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein serum Severe acute respiratory syndrome significantly lower spike Spike protein Stratification subject the healthy the patient the receptor-binding domain were measured Zinc zinc ion zinc supplementation [DOI] 10.3389/fimmu.2021.785599 PMC 바로가기 [Article Type] Immunology
Exploring COVID-19 pathogenesis on command-line: A bioinformatics pipeline for handling and integrating omics data명령줄에서 COVID-19 발병 기전 탐색: omics 데이터를 처리하고 통합하기 위한 생물정보학 파이프라인Article Published on 2022-01-012022-09-11 Journal: Advances in protein chemistry and structural biolo [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Bioconductor bioinformatics cholesterol cholesterol metabolism cohort of patients comprehensive view coronavirus COVID-19 COVID-19 pathogenesis Data integration Differentially expressed genes ECM experiment global public health handling healthy highly pathogenic immune system activity infected individuals infected patients information knowledge leukocyte lung mapped marker mechanism metabolism molecules offer Open Access pathway Pathways plasma proteasomal degradation Protein Proteins proteome proteomics Quantitative raw data regulated robust robustness SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 transcript Transcriptome transcriptomics transcriptomics data transcripts virus Wuhan Wuhan, China [DOI] 10.1016/bs.apcsb.2022.04.002 PMC 바로가기 [Article Type] Article