Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entryResearch Published on 2009-12-242022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] assays cell entry cell-cell fusion cells characteristic Critical cysteine cysteines described domain glycine hydrophobic investigated lysine membrane fusion motif Particle pseudotyped Receptor binding residue Result SARS Coronavirus SARS CoV SARS-CoV Spike protein target cells the S protein transmembrane domain viral membrane virus [DOI] 10.1186/1743-422X-6-230 PMC 바로가기 [Article Type] Research
Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In VitroResearch Article Published on 2009-11-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 16HBE ACE2 ACE2 binding Activation acute respiratory syndrome against SARS-CoV airway Amino acid analysis arginine residue bronchial bronchial epithelial cell cell entry Chromatography cleavage cleaved coronavirus demonstrated dependent on different Efficacy Efficiency exhibited expand expressing expression Extracellular finding full-length glycoprotein host cell HPLC Human implication in vitro investigated lack liquid mechanism molecular basis mutant not affect performance potential therapeutic agent protease Proteases Protein R667 R797 Receptor binding regulate Respiratory system S-protein SARS-CoV SARS-CoV infection Sequencing shown spike susceptibility susceptible Treatment trimer trypsin viral entry viral envelope virus virus entry [DOI] 10.1371/journal.pone.0007870 PMC 바로가기 [Article Type] Research Article
Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibilityArticle Published on 2008-05-272023-05-31 Journal: Proceedings of the National Academy of Sciences of [Category] Fulltext, 조류인플루엔자, [키워드] animal model hemagglutinin Receptor binding Transmission [DOI] 10.1073/pnas.0801259105 PMC 바로가기
Conformational Reorganization of the SARS Coronavirus Spike Following Receptor Binding: Implications for Membrane FusionResearch Article Published on 2007-10-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 ACE2 binding Analysis angiotensin-converting enzyme 2 Cell culture change conformational change Cryo-electron microscopy domain fusion in viral initial Isolation membrane fusion molecular morphology occur produced Protein Proteins provide purified receptor Receptor binding reorganization SARS Coronavirus SARS-CoV shown spike subsequent transmembrane domains viral spike virion [DOI] 10.1371/journal.pone.0001082 PMC 바로가기 [Article Type] Research Article
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike proteinArticle Published on 2006-04-172022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] affected Anti-viral antiviral activity Asia Atypical cell cytotoxicity Class I viral fusion protein Concentration concentrations coronavirus CoV domain dose-dependent Effect Europe fusion peptide fusion protein glycoprotein heptad repeat hydrophobicity IC50 identify inhibited inhibition inhibitor membrane membrane fusion MHV murine hepatitis virus N-terminus North America peptide Peptide inhibitor Pneumonia provide recent Receptor binding Region regions responsible S2 subunit SARS-CoV severe Severe acute respiratory syndrome-associated coronavirus six-helix bundle tested the S protein viral infectivity viral spike viral spike protein was used white [DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article