Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variantsIgM의 비강 전달은 SARS-CoV-2 변종으로부터 광범위한 보호를 제공합니다.Article Published on 2021-07-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] (alpha (Beta Administered administration Alpha antibody antibody-based therapy B.1.1.7 B.1.351 B.1.351 variants Beta body weight Brazil COVID-19 Critical domain dose effective Efficacy Emergency use ENhance epitope exhibit Gamma IgG IgG antibodies IgG antibody IgM Immunoglobulin Immunoglobulin G immunoglobulin M IMPROVE intranasal intranasally mice mutants neutralize Neutralizing neutralizing antibody offer overcome P.1 parental Prophylactic raised reduce resistance rodents safety profile SARS-CoV-2 SARS-CoV-2 variant single dose South therapeutic therapeutic efficacy Therapeutic treatment variant virus [DOI] 10.1038/s41586-021-03673-2 PMC 바로가기 [Article Type] Article
Does hydroxychloroquine still have any role in the COVID-19 pandemic?하이드록시클로로퀸이 COVID-19 전염병에서 여전히 어떤 역할을 합니까?Article Published on 2021-07-012022-09-11 Journal: Expert opinion on pharmacotherapy [Category] SARS, 신약개발, 치료제, [키워드] adoption Antiviral antiviral activity antiviral drug antiviral drugs Area benefit candidate Cardiotoxicity Chloroquine clinical trial clinical trials complex conditions controlled trials COVID-19 COVID-19 pandemic Dexamethasone dosage drug drugs Evidence experiment expert hospitalized patient hospitalized patients Hydroxychloroquine IL-6 IL-6 receptor antagonists immunomodulator immunomodulators in vitro data in vivo Infection Interpretation malaria pharmacokinetics prevention Randomized controlled trial RCT RCTs rheumatological safety profile SARS-CoV-2 severe COVID-19 Support therapeutic Tolerability Treatment widespread [DOI] 10.1080/14656566.2021.1898589 PMC 바로가기 [Article Type] Article
Safety and effectiveness concerns of lopinavir/ritonavir in COVID-19 affected patients: a retrospective seriesCOVID-19 영향을 받는 환자에서 로피나비르/리토나비르의 안전성 및 유효성 문제: 후향적 시리즈Article Published on 2021-07-012022-09-11 Journal: Clinical toxicology (Philadelphia, Pa.) [Category] SARS, 치료제, [키워드] addition affected Antiviral Case series case sery cholestasis Combination Concentration coronavirus disease COVID-19 COVID-19 patient COVID-19 patients dyslipidemia EC50 Effect Effectiveness electrolyte imbalance Elevation exceeded Gastrointestinal symptom gastrointestinal symptoms greater HIV HIV patients Human immunodeficiency virus hyponatremia immunodeficiency virus In-vitro liver enzyme Lopinavir Lopinavir/ritonavir LPV Novel coronavirus novel coronavirus disease occur overdose Patient raise raising reached retrospective Ritonavir Safety safety profile SARS-CoV-2 side Side effect Side effects therapeutic threshold thresholds Toxicity Treatment Triglyceride [DOI] 10.1080/15563650.2020.1842882 PMC 바로가기 [Article Type] Article
Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious DiseasesImmunology Published on 2021-06-092022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] animal model antibody antiparasitic drug application benefit chicken chicken immunoglobulin conserved Diseases Efficacy Health homolog Human human immunoglobulin IgG IgY Immunoglobulin immunoglobulin Y infections Infectious disease pathogen Potential safety profile shown Treatment Vaccine variety viral (or virus) [DOI] 10.3389/fimmu.2021.696003 PMC 바로가기 [Article Type] Immunology
Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide EvidenceMedicine Published on 2021-06-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] aggregate approach arising benefit contribute convalescent plasma Convalescent plasma therapy coronavirus disease Course COVID-19 COVID-19 patient demonstrated Efficacy Evidence greater health emergency healthcare IMPROVE Infectious disease Kaplan–Meier Kaplan–Meier survival plot Kaplan–Meier survival plots Kaplan–Meier analysis meta-analytical mosaic Outbreaks passive antibody transfer Patient patient mortality patient survival patients hospitalized performed plasma prevent disease progression provided Qualitative Randomized controlled trial RCT RCTs reported required safety profile SARS-CoV-2 supportive therapies survival the disease transfused treat viral clearance [DOI] 10.3389/fmed.2021.684151 PMC 바로가기 [Article Type] Medicine
The pulmonary route as a way to drug repositioning in COVID-19 therapyReview article Published on 2021-06-012022-10-05 Journal: Journal of Drug Delivery Science and Technology [Category] 신약개발, 치료제, [키워드] addition administration Affect affecting approach caused clinical clinical trial clinically common drug Comorbidity conducted coronavirus COVID-19 Direct drug drug candidate Drug repurposing effective facilitate greater in silico Interaction literature review lung New coronavirus objective outbreak pandemic public health pulmonary drug delivery Pulmonary formulations Replication respiratory tract Result safety profile SARS-CoV-2 Science the disease therapy Treatment viral infection Web of Science [DOI] 10.1016/j.jddst.2021.102430 [Article Type] Review article
Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infectionClinical Trial Published on 2021-06-012022-10-05 Journal: Pathogens and global health [Category] 임상, [키워드] addition Admission age Antibiotics Anticoagulant approved Brazil caused Chloroquine coronavirus Corticosteroid COVID-19 death diabetes double-blind drug drugs Effectiveness Efficacy Endpoint form groups HCQ Hospital admission hospitalized patient Hydroxychloroquine ICU ICU admission incidence independent independent risk factor invasive ventilation IRB Ivermectin male manifestation Mortality no difference not reduce obesity objective Older pandemic participant Patient patients patients hospitalized performed Phase 2 Phase 2 study Physicians predictor pulmonary involvement Randomized randomized study reference Result safety profile SARS-COV-2 infection Serious Adverse Event supplemental oxygen tested three group [DOI] 10.1080/20477724.2021.1890887 PMC 바로가기 [Article Type] Clinical Trial
Brief review of the mRNA vaccines COVID-19mRNA 백신 COVID-19에 대한 간략한 검토Review Published on 2021-06-012022-09-11 Journal: Inflammopharmacology [Category] SARS, 변종, [키워드] COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines defined DNA vaccine effective Health highlight Immunity immunization strategies inactivated indicated mRNA mRNA vaccine mRNA vaccines organ damage Pharmacology Preventive medicine Protein subunit representing safety profile SARS-CoV-2 variants serious complication therapeutic agent therapeutic agents treat vaccination Vaccine Viral vector virus [DOI] 10.1007/s10787-021-00811-0 PMC 바로가기 [Article Type] Review
Thrombotic Thrombocytopenia after COVID-19 Vaccination: In Search of the Underlying MechanismReview Published on 2021-05-272022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adenoviral vector adverse effect adverse effects adverse event antibody associations AZD1222 benefit cause clinical trials COVID-19 COVID-19 vaccination COVID-19 vaccine cross-reactivity Europe European country Evidence expression hypothese immune response Interaction measure mechanism mRNA vaccines multifactorial pandemic PF4 Platelet Platelets Protein reaction Reactions Regulatory reported Research safety profile SARS-CoV-2 spike protein Spike protein subsequent The United States thrombocytopenia thromboembolic thrombosis thrombotic thrombotic event transmission of SARS-CoV-2 Vaccine Vaccine hesitancy Vaccines vector vaccines [DOI] 10.3390/vaccines9060559 PMC 바로가기 [Article Type] Review
High-dose vitamin-C induced prolonged factitious hyperglycemia in a peritoneal dialysis patient: a case reportCase Report Published on 2021-05-212022-10-30 Journal: Journal of Medical Case Reports [Category] Coronavirus, SARS, [키워드] administration adverse event ascorbic acid Case report Coma coronavirus disease COVID-19 End-stage renal disease enrolled event Glucose High-dose High-dose vitamin C highlight hyperglycemia hypoglycemia iatrogenic increasingly infections insulin intensive care intravenous Laboratory Patient patients treated Peritoneal dialysis persistence point-of-care populations protocol amendment randomized placebo-controlled trial reported safety profile Sepsis Septic shock short-lived study drug Support therapy triggered unblinding Vitamin C [DOI] 10.1186/s13256-021-02869-4 PMC 바로가기 [Article Type] Case Report