Antigen-Specific CD4 + T-Cell Activation in Primary Antibody Deficiency After BNT162b2 mRNA COVID-19 VaccinationBNT162b2 mRNA COVID-19 백신 접종 후 1차 항체 결핍에서 항원 특이적 CD4 + T-세포 활성화Immunology Published on 2022-02-142022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Activation activation induced marker assay antibody BNT162b2 BNT162b2 mRNA CD134 CD25 CD4 cells circulating circulating follicular T helper cells common variable immunodeficiency COVID-19 COVID-19 vaccination CVID CXCR5-negative CD4+ memory T cells deficiency Detection limit ELISA examined flow cytometry follicular form functional antibody response healthy control identify IgA antibody IgG IgG antibodies IgG response immune response immunodeficiency Immunoglobulin Inconclusive marker memory cell memory T cell memory T cells of BNT162b2 Patient patients with CVID peptides previous study primary antibody primary immunoglobulin isotype deficiency SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein second dose selective stimulated surrogate virus neutralization assay T cell T cell subset the patient vaccination Vaccine vaccine antigen Virus neutralization were measured [DOI] 10.3389/fimmu.2022.827048 PMC 바로가기 [Article Type] Immunology
Pango lineage designation and assignment using SARS-CoV-2 spike gene nucleotide sequencesSARS-COV-2 스파이크 유전자 뉴클레오티드 서열을 사용한 판고 계통 지정 및 할당Research Article Published on 2022-02-112022-09-10 Journal: BMC Genomics [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] Analysis assigned classification Complete COVID-19 pandemic Disease surveillance facilitate foundation genetic diversity Genomic surveillance Health policy information Lineage lineages Mutation nucleotide nucleotide sequence outbreak Pango Precision public health Result SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 lineage SARS-CoV-2 spike sequence spike spike gene supplementary material These data variants variants of concern virus genomes [DOI] 10.1186/s12864-022-08358-2 PMC 바로가기 [Article Type] Research Article
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individualsSARS-CoV-2에 대한 타액 IgG는 혈청 전환을 나타내며 mRNA 백신 접종 면역 저하된 개인의 혈청 중화와 상관 관계가 있습니다Article Published on 2022-02-112022-09-12 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome ALF Allogeneic Analysis Anti-SARS-CoV-2 S antibody Antigen AUC Cancer CAR-T caused center CLL CLL patient comparable coronavirus correlated Council COVID-19 disease dose Elecsy entire cohort foundation group healthy control HIV Human immunodeficiency virus IgG IgG response IgG titer immunocompromised individual immunodeficiency Immunoglobulin immunosuppressants indicate individual Infection Innovation Knut leukemia Medical Research Council mRNA BNT162b2 mRNA BNT162b2 vaccine multiplex neutralizing capacity parameter participated Patient PID Positive predictive value PPV predictive power Primary Immunodeficiency primary site Prospective clinical trial reactivity receiver operating characteristic receptor Region response responses revaccination Saliva salivary SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike antigen Seroconversion serum Serum Neutralization solid organ transplantation SOT spike IgG Stem cell transplantation Stockholm County susceptible Swedish T cell therapy transplantation vaccination vaccine response Vaccine-induced immunity were measured [DOI] 10.1016/j.medj.2022.01.001 PMC 바로가기 [Article Type] Article
Cellular Responses to Membrane and Nucleocapsid Viral Proteins Are Also Boosted After SARS-CoV-2 Spike mRNA Vaccination in Individuals With Either Past Infection or Cross-ReactivityMicrobiology Published on 2022-02-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] asymptomatic infection benefit booster CD8 Cell Cellular immune response cellular response Clinical efficacy COVID-19 cross-reactivity epitope first dose General population highlight individual individuals Infection membrane mRNA mRNA vaccine N proteins nucleocapsid performed priming Protein response SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 spike shown spike spike- T-cell T-cell analysis T-cell Response tested the vaccine Viral variants [DOI] 10.3389/fmicb.2021.812729 PMC 바로가기 [Article Type] Microbiology
Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitroCoronaviruses Published on 2022-02-102022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] Acidic acute respiratory syndrome Affect antiviral activity Antiviral compound approach B.1.1.7 B.1.351 B.1.617.2 Beta blocked cathepsin L caused Cell clinical virus isolates Compound Concentration coronavirus Coronavirus disease 2019 COVID-19 cysteine protease Delta effective endocytosis Endosomal acidification enzymatic activity expressing furin furin protease global pandemic hACE2 HIV human Angiotensin-converting enzyme human lung in vitro inhibit intestinal cell MCL-1 mechanisms membrane fusion Obatoclax prevented Protein pseudotype reducing reporter S protein Safe SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike SARS-CoV-2 variant set off suggested the SARS-CoV-2 Treatment unmet need virion virus virus entry [DOI] 10.1080/22221751.2022.2026739 PMC 바로가기 [Article Type] Coronaviruses
A Feasible Alternative Strategy Targeting Furin Disrupts SARS-CoV-2 Infection Cycle푸린을 표적으로 하는 실행 가능한 대안 전략은 SARS-CoV-2 감염 주기를 방해합니다Research Article Published on 2022-02-092022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 Activation addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody Response applicability approach binding blockade Cell cellular entry chain cleavage competing coronavirus COVID-19 Critical cycle described disease pathology DNA domain effective Efficacy epitope flexible linker furin Health Hospitalization Host host cell host cells host protease human lung cell human lung cells IgG1 Immunological memory in viral independent Infection infection cycle infections interfere lung cells membrane fusion Mortality occur overcome peptide plug processing producing protease Proteases proteolytic activation Proteolytic processing public health threat remained remains uncertain residue RNA SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viral particles scenario secretory pathway solution spike glycoprotein Spike protein Strategy subsequent targeted therapy targeting the spike protein Transmission Vaccine Viral viral entry Viral transmission virus virus-producing cell virus-producing cells viruses [DOI] 10.1128/spectrum.02364-21 PMC 바로가기 [Article Type] Research Article
Robust validation and performance comparison of immunogenicity assays assessing IgG and neutralizing antibodies to SARS-CoV-2SARS-COV-2에 대한 IgG 및 중화 항체를 평가하는 면역 원성 분석의 강력한 검증 및 성능 비교Research Article Published on 2022-02-072022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 spike protein antibody Antibody titer Antibody titers approach Benchmarking calibrated convalescent coronavirus coronavirus disease Coronavirus disease 2019 correlation criteria cross-reactivity demonstrated domain donors ECL functional functional immune response human serum IgG immune response immune responses immunogenicity immunogenicity assay immunogenicity assays immunogenicity data Immunoglobulin Immunoglobulin G International international units Meso Scale Discovery microneutralization MNT MSD multiplex Neutralizing activity Neutralizing antibodies neutralizing antibody nucleocapsid outcome Precision Protein Quantitative RBD RBD protein RBD proteins reference standard regimens Reporting respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike SARS-CoV-2 vaccination scale seasonal coronaviruses selectivity sera serologic severe acute respiratory syndrome Coronavirus specificity spike and RBD proteins Spike protein tested the WHO vaccinated individuals vaccination Vaccine Vaccines virus were assessed [DOI] 10.1371/journal.pone.0262922 PMC 바로가기 [Article Type] Research Article
In Silico Molecular Characterization of Human TMPRSS2 Protease Polymorphic Variants and Associated SARS-CoV-2 SusceptibilityArticle Published on 2022-02-032022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] 2019 coronavirus disease acute respiratory syndrome addition Alter Analysis analyzed Camostat mesylate cell entry characterization complex coronavirus COVID-19 develop docking drug examined global pandemic glycoprotein Health care system high affinity host susceptibility Human Infection inhibitors Interaction interactions intermolecular interaction investigated molecular molecular docking nafamostat pandemic Polymorphic Polymorphisms predicted protease inhibitors Protective proteolytic cleavage reported responsible S glycoprotein SARS-CoV-2 SARS-CoV-2 spike serine protease serine protease inhibitors Spike protein Spread Structural analysis susceptibility the SARS-CoV-2 TMPRSS2 transmembrane serine protease treating COVID-19 patients Type variant variants Variation [DOI] 10.3390/life12020231 PMC 바로가기 [Article Type] Article
Molecular dynamic simulation analysis of SARS-CoV-2 spike mutations and evaluation of ACE2 from pets and wild animals for infection riskSARS-CoV-2 스파이크 돌연변이의 분자 역학 시뮬레이션 분석 및 감염 위험에 대한 애완 동물 및 야생 동물의 ACE2 평가Article Published on 2022-02-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor ACE2 receptor recognition Analysis animal Animal host binding binding ability binding affinity caused contagious coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical glycoprotein health emergency Host human ACE2 humans infection risk interact Interaction intermediate host life Missense mutation Missense mutations modeling mole molecular dynamics molecular dynamics simulations Molecular modeling Mus mutant Mutation mutations PALM Pandemics pangolin question RBD RBD region Receptor-binding domain reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 transmission spike gene spike glycoprotein Spike mutant Spike protein Stress susceptibility the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 the spike protein transmission of SARS-CoV-2 transmitted viral spike virus vole wild animal wild animals [DOI] 10.1016/j.compbiolchem.2021.107613 PMC 바로가기 [Article Type] Article
Occurrence of a substitution or deletion of SARS-CoV-2 spike amino acid 677 in various lineages in Marseille, France프랑스 마르세유의 다양한 계통에서 SARS-CoV-2 스파이크 아미노산 677의 치환 또는 결실의 발생Article Published on 2022-02-012022-09-11 Journal: Virus Genes [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Amino acid amino acids change collected convergent evolution COVID-19 database Deletion described E484K eight emergence Evolution example FIVE France Genome genomes incidence independent lineages involved L18F L452R Lineage lineages Marseille MOST N501Y pangolin Patient Q677 Q677H raised respiratory sample Respiratory samples SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants searched sequence Seven Substitution USA variant [DOI] 10.1007/s11262-021-01877-2 PMC 바로가기 [Article Type] Article