Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies Research Published on 2022-03-232022-10-05 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome administration analyzed antibody antibody treatment coronavirus country delta variant elevated immunocompromised individual individual individuals Infection inhibited mAbs monoclonal antibody Mutation neutralization neutralized Neutralizing activity Neutralizing titer nine not neutralize noticeable difference omicron Patient Prevent receiving recipient recipients reduced SARS-CoV-2 sensitivity sera therapeutic treated [DOI] 10.1038/s41591-022-01792-5 [Article Type] Research
Sensitive and specific serological ELISA for the detection of SARS-CoV-2 infectionsSARS-CoV-2 감염 검출을 위한 민감하고 특이적인 혈청학적 ELISAArticle Published on 2022-03-192022-09-11 Journal: Virology Journal [Category] SARS, 치료기술, 치료법, [키워드] 113 patient 113 patients 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody levels Antibody titer Antibody titers approved Asymptomatic collected coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 cytomegalovirus develop early phase ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Enzyme-linked immunosorbent assay (ELISA) epidemiological data Epstein Barr virus Escherichia coli Hepatitis herpes simplex herpes simplex virus hospitalized COVID-19 patient hospitalized COVID-19 patients human serum identify IgG antibodies IgG immune response immune response immunodeficiency Infection Mild N-protein nucleocapsid protein Nucleocapsid protein (N-protein) number of infected pandemic Pathogens Patient PCR positive PCR test produced Protein provided purified remained RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2 specific antibodies SARS-CoV-2 spike sensitive sensitivity sera serological serological assays serological test serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe symptom severe symptoms specific IgG antibody specificity symptom onset symptomatic infections tested the SARS-CoV-2 triggered Vaccine virus [DOI] 10.1186/s12985-022-01768-4 PMC 바로가기 [Article Type] Article
High seroprevalence of anti-SARS-CoV-2 antibodies among Ethiopian healthcare workers에티오피아 의료 종사자들 사이에서 항 SARS-CoV-2 항체의 높은 혈청 유병률Article Published on 2022-03-162022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 치료기술, [키워드] 95% CI adjusted odds ratio African analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies Antibody testing AOR association asymptomatic infection blood sample Blood samples Care Clinical data close contact collected combating Community Contact contact with COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic Demographic and clinical data Descriptive statistics determine develop ELISA enzyme enzyme-linked immunosorbent assay estimate Ethiopia Ethiopian exposure to Factors females FIVE General population guide had no Harar Health Health care Health care system health system healthcare worker Healthcare workers higher risk highest highlight hospitals house IgG Infection information Logistic regression lowest measure multivariate logistic regression no symptoms onset of symptom pandemic patients with SARS-CoV-2 potential risk Prevalence provided Public Hospital Ratio RBD Receptor binding domain Region SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 seroprevalence sensitivity sera serology seropositive Seropositivity Seroprevalence serum sample serum samples specificity sub-Saharan Africa Symptom Symptoms Transmission virus were used with COVID-19 [DOI] 10.1186/s12879-022-07247-z PMC 바로가기 [Article Type] Article
Multiple SARS-CoV-2 Variants Exhibit Variable Target Cell Infectivity and Ability to Evade Antibody Neutralization다양한 SARS-CoV-2 변이체가 다양한 표적 세포 감염성과 항체 중화 회피 능력을 나타냄Article Published on 2022-03-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] Ability addition antigenicity B.1.617.2 BBIBP-CorV BBIBP-CorV vaccine binding affinity blocked changed CoronaVac CoronaVac vaccine coronavirus disease Coronavirus disease 2019 COVID-19 D614G elicited Evolution of SARS-CoV-2 exacerbated host cell host cells Immune escape immune evasion in viral infect Infection Infectivity inhibit inhibitors less mAb mAbs monoclonal antibody Multiple Mutation Neutralizing Neutralizing antibodies neutralizing antibody pandemic polyclonal antibodies polyclonal antibody Protease inhibitor protease inhibitors Protein proteolytic provide pseudovirus receptor S protein SARS-coronavirus SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera significantly stomatitis susceptible cell target the S protein therapeutic vaccination variable variant variants variants of concern vesicular stomatitis vesicular stomatitis virus Viral viral entry viral infection viral infectivity virus infection VoC was used were assessed [DOI] 10.3389/fimmu.2022.836232 PMC 바로가기 [Article Type] Article
A Novel Quantitative Multi-Component Serological Assay for SARS-CoV-2 Vaccine EvaluationSARS-CoV-2 백신 평가를 위한 새로운 정량적 다성분 혈청학적 분석Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료법, [키워드] Accuracy Algorithm Analysis anti-SARS-CoV-2 array assays carried clinical trials conditions COVID-19 exposure times fluorescent generate house humoral Humoral response IgA IgG IgM Immunoglobulin immunoglobulins International international standard linear linearity methodology Microarray naïve normalized novel Nucleocapsid proteins positive Precision q-RT-PCR qRT-PCR quantitation Quantitative Receptor binding domain Result SARS-CoV-2 SARS-CoV-2 patients SARS-CoV-2 spike SARS-CoV-2 vaccines sera seroconverted serum Specific specificity the microarray the SARS-CoV-2 the WHO unique Vaccine [DOI] 10.1021/acs.analchem.1c05264 PMC 바로가기 [Article Type] Article
Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of ConcernCOVID-19 회복기의 면역 반응에 대한 종단적 추적은 우려의 다른 SARS-CoV-2 변종에 대한 오미크론 및 시차 손상에 대한 중화 활성의 부재를 나타냅니다Article Published on 2022-03-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] activity Against Alpha alpha and delta variants analyzed antibodies association B cell B cells Beta cellular immunity cellular response Cellular responses changes in clearance Cohort concern Correlation analysis COVID-19 decrease Delta Delta variants Evaluating flow cytometry Gamma humoral humoral and cellular immunity humoral immune response IgG antibody IgG titer immune Immunity indicate indicated individual investigated lack long-lasting longitudinal memory memory B cell memory B cells neutralization capacity neutralization test Neutralizing antibodies neutralizing antibody omicron Omicron variants Other Patient patients persistence Perturbation phenotype Prospective Study protection Protective response SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 variant SARS-CoV-2 variants sera spike Spike-specific memory B cells surrogate virus neutralization test the disease variant variants variants of concern Viral virus neutralization test was measured Wuhan strain [DOI] 10.3389/fimmu.2022.863039 PMC 바로가기 [Article Type] Article
Antiviral metabolite 3′-deoxy-3′,4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19항바이러스 대사 산물 3'-deoxy-3',4'-didehydro-cytidine은 혈청에서 검출 가능하며 COVID-19를 포함한 급성 바이러스 감염 식별Article Published on 2022-03-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI acute infection acute viral infection Admission an area Antiviral AUC Bacterial Bacterial infection Bacterial infections Biomarker characteristic CMPK2 Cohort correlated COVID-19 Critical cytidine ddhC detectable Diagnosis diagnostic diagnostics emergency department enzyme Enzymes examined FIVE Gene Expression healthy controls High-resolution highlight identify implicated in viral in vivo independent inflammatory conditions interferon Liquid chromatography management marker mass spectrometry metabolite metabolome metabolomics NIHR pandemic Patient precursor Profiling receiver operating characteristic receiver operating characteristic curve responsible sera serum significantly small molecule Support transcripts validation cohort viperin Viral viral infection viral infections [DOI] 10.1016/j.medj.2022.01.009 PMC 바로가기 [Article Type] Article
Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern전염병 초기에 COVID-19 환자의 혈청은 우려의 변이에 대한 교차 중화의 제한된 증거를 보여줍니다Article Published on 2022-03-102022-09-11 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibody Antibody Response Antibody responses Beta chemokine chemokines clinical symptom Clinical symptoms Cohort cohort of patient Concentration coronavirus COVID-19 patient Critical critical state cross-neutralization cytokine Cytokines Delta detectable determine Evidence evidence of examined highlight Human human serum Immune status infected with SARS-CoV-2 Infection mechanism Mild mild to moderate moderate moderate infections moderate to severe Neutralizing antibodies neutralizing antibody pandemic pathogen Patient plasma Re-infection Recovered COVID-19 patients respiratory SARS-CoV-2 sera serum serum and plasma severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severe cases severe disease Severity of infection significantly increased variants variants of concern variety [DOI] 10.1038/s41598-022-07960-4 PMC 바로가기 [Article Type] Article
Novel Synthetic Lipopeptides as Potential Mucosal Adjuvants Enhanced SARS-CoV-2 rRBD-Induced Immune ResponseSARS-CoV-2 rRBD 유도 면역 반응을 향상시키는 잠재적 점막 보조제로서의 새로운 합성 리포펩티드Article Published on 2022-03-092022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activity adjuvant adjuvants Affect agonist agonists Bacterial BALF candidate vaccine charged residue COVID-19 vaccine CSK cytotoxicity Effect enhanced evaluated exhibited Figuring IgA IgG immune response immunized in vitro induce investigated lipopeptide lipoprotein mimicking mucosal N-terminal nasal novel OVA peptide Potential promote RBD residue response rRBD SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 rRBD sequence sera serum significantly increased significantly lower Structure Structure-activity relationship suggested Support support vector machine SVM synthetic the SARS-CoV-2 TLR2 Vaccine vaccine adjuvant [DOI] 10.3389/fimmu.2022.833418 PMC 바로가기 [Article Type] Article
Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the comirnaty COVID-19 vaccine in nursing home residents요양원 거주자의 Comirnaty Covid-19 백신에 의해 유발 된 SARS-COV-2 변이체에 대한 중화 항체Article Published on 2022-03-082022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] antibody Beta Beta variant breadth co-morbidities co-morbidity concurrence COVID-19 vaccine Delta delta variant elicited Epsilon Fold change followed by frailty Gamma groups had no humoral immune responses immune responses immunology immunosenescence individual lowest morbidities naïve neutralize nursing home Older age participant reduction in SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant sera serum severe COVID-19 Spike protein the SARS-CoV-2 Vaccines variant variants variants of concern Virology VOCs Wuhan-Hu-1 [DOI] 10.1038/s41598-022-07849-2 PMC 바로가기 [Article Type] Article