Clinical outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) variant and BA.1/BA.1.1 or BA.2 subvariant infection in Southern California Research Published on 2022-06-082022-10-05 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] acute respiratory syndrome Admission B.1.1.529 B.1.617.2 change clinical Clinical outcome coronavirus COVID-19 death Delta delta variant dominant explained hazard ratio healthcare Healthcare system Hospital admission Hospitalization immune protection individual Infection infections intensive care Lower mechanical ventilation occurred omicron outcome progression public health reduced reduced risk risk SARS-CoV-2 SARS-CoV-2 lineage severity Surveillance symptomatic vaccinated against COVID-19 variant [DOI] 10.1038/s41591-022-01887-z [Article Type] Research
Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine재조합 식물 기반 면역증강제 코로나19 백신의 효능 및 안전성Clinical Trial Published on 2022-06-022022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adverse event age Analysis AS03 assigned baseline candidate vaccine caused conducted coronavirus coronavirus disease Coronavirus disease 2019 CoVLP CoVLP+AS03 determine disease dose effective Efficacy Factor FIVE incidence injection intention-to-treat intention-to-treat population Intramuscular injection Local median age Median viral load Medicago Mild moderate occurred participant Participants participated Particle performed Phase 3 Placebo placebo group placebo-controlled trial plant plants polymerase post-hoc analysis prefusion produced Randomized receive recombinant respiratory Safety SARS-CoV-2 sequenced Sequencing seronegative severe acute respiratory syndrome Coronavirus Severe case Spectrum spike glycoprotein symptomatic symptomatic COVID-19 symptomatic infection System systemic adverse event systemic adverse events the median the placebo group the vaccine Trial two group two groups Vaccine vaccine efficacy vaccine group variant variants Viral Viral load viral sample Volunteer [DOI] 10.1056/NEJMoa2201300 PMC 바로가기 [Article Type] Clinical Trial
Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar Research Published on 2022-06-022022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] BNT162b2 booster dose case-control study comparable conducted COVID-19 hospitalization death declined declining dose Duration Effectiveness highest Infection infections moderate mRNA COVID-19 vaccine mRNA vaccine mRNA-1273 vaccine omicron SARS-CoV-2 second dose short-lived symptomatic [DOI] 10.1038/s41467-022-30895-3 [Article Type] Research
Efficacy and Safety of the RBD-Dimer-Based Covid-19 Vaccine ZF2001 in Adults성인에서 RBD-이량체 기반 코비드-19 백신 ZF2001의 효능 및 안전성Clinical Trial Published on 2022-06-022022-09-25 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome Adults adverse event Adverse reaction age aluminum Analysis assigned China Clinical Center clinical trials conducted coronavirus coronavirus disease Cutoff death deaths dimeric dose double-blind effective Efficacy efficacy analysis efficacy end point Follow-up hydroxide immunogenic incidence Indonesia large cohort Major MOST occurred Occurrence participant Participants phase 3 trial Placebo placebo-controlled primary end point primary end-point Randomized Randomly receive regimen reported Safe Safety safety analysis Science Serious Adverse Event shown Side-effect symptomatic technology the placebo group the receptor-binding domain Trial two groups vaccination Vaccine was performed ZF2001 [DOI] 10.1056/NEJMoa2202261 PMC 바로가기 [Article Type] Clinical Trial
A global report on the dynamics of COVID-19 with quarantine and hospitalization: A fractional order model with non-local kernelResearch article Published on 2022-06-012022-10-05 Journal: Computational biology and chemistry [Category] 유전자 메커니즘, [키워드] ABC America Americas Analysis Asia Asymptomatic Atangana-Baleanu (ABC) Fractional Derivative basic reproduction number calculated classical COVID-19 decrease Disease Free Equilibrium eight Endemic Endemic Equilibrium Europe high risk Hospitalized individuals infected individual Infection infection rate mathematical MATLAB parameter parameters predicted quarantine rate of infection reduce reported shown Spread susceptible symptomatic Treatment Variation was obtained [DOI] 10.1016/j.compbiolchem.2022.107645 [Article Type] Research article
Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer therapies항암치료를 받는 환자의 코로나19 백신접종에 대한 항체 및 T세포 반응Article Published on 2022-06-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료제, [키워드] active treatment adrenal crisis Adrenal insufficiency Affect Anti-CD20 antibodies Anti-CD20 antibody Anti-viral antibodies antibody antibody formation Antibody titer Antibody titers Anticancer therapy B cells B-cell B.1.617.2 blockade Cancer CD4 CD8 Cell cellular Chemoimmunotherapy Chemotherapy Corticosteroids COVID-19 COVID-19 infection COVID-19 infections COVID-19 vaccination COVID-19 vaccinations COVID-19 vaccine trials cross-reactive cytokine detectable develop dose doses effector cells Endocrine expressed follicular generate healthy donor healthy donors helper cells Humoral response hypoadrenalism Hypothesis IgG antibody titer immune Immunocompromised immunogenic immunogenicity immunogenicity, vaccine Immunotherapy intracellular cytokine staining Lymphocytes mRNA vaccine Multiple myeloma Myeloma n=36 no differences oncology patients Participants Patient Patients with cancer PD-1 peptide peptides Phase 3 profile Prophylactic RBD reactivity receiving Receptor binding domain Safe seronegative seronegative patient Side effect solid tumors spike Spike protein steroid Steroids Stress symptomatic T cell T cell response T cell responses T cells T follicular helper cells T-lymphocytes targeted therapy the SARS-CoV-2 therapy Treatment treatment groups tumors Two patient two patients vaccination Vaccinations Vaccine variant spike was measured were assessed were excluded wild-type WT spike [DOI] 10.1136/jitc-2022-004766 PMC 바로가기 [Article Type] Article
Low risk of nosocomial severe acute respiratory syndrome-coronavirus-2 infection in patients with liver disease admitted to a hepatology unit at an academic hospital: A single-center experience학술 병원의 간과 병동에 입원 한 간 질환 환자의 병원 내 중증 급성 호흡기 증후군 - 코로나 바이러스 -2 감염의 낮은 위험 : 단일 센터 경험Article Published on 2022-06-012022-09-12 Journal: Indian journal of gastroenterology : official jour [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Admission anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibodies clinical evaluation determine diagnostic enrolled evaluated Hepatocellular carcinoma history hospital Hospital admission Hospital admissions IgG IgM IgM antibody immune dysfunction Immunoglobulin Immunoglobulin G immunoglobulin M Immunosuppression increased risk Infection liver Liver cirrhosis Liver disease Liver transplantation Nasopharyngeal swab nosocomial Nosocomial infection occurred one patient Patient performed polymerase chain positive reverse transcriptase Reverse transcriptase polymerase chain reaction risk RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination serum single-center study period Support symptomatic symptomatic SARS-CoV-2 infection tested the patient therapeutic transmission of SARS-CoV-2 vaccination [DOI] 10.1007/s12664-022-01241-8 PMC 바로가기 [Article Type] Article
Factors Associated with Post-Acute Sequelae of SARS-CoV-2 (PASC) After Diagnosis of Symptomatic COVID-19 in the Inpatient and Outpatient Setting in a Diverse CohortObservational Study Published on 2022-06-012022-10-04 Journal: Journal of General Internal Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI acute COVID-19 Anosmia association baseline BMI Clinical characteristics clinical factor clinical symptom Cohort conducted COVID-19 COVID-19 infection death demographic development diabete evaluate Factor fatigue Follow-up functional greater hospital discharge Hospitalized hospitalized patient incidence index Infection information Inpatient laboratory-confirmed Medicaid Odds ratio Older age older patients Organ transplant Outpatient outpatients PASC Patient Population Prospective questionnaire risk factor risk of death SARS-CoV-2 setting Shortness of breath subset survivor Symptom symptomatic USA vulnerability while with COVID-19 [DOI] 10.1007/s11606-022-07523-3 PMC 바로가기 [Article Type] Observational Study
Prolonged viral shedding identified from external splints and intranasal packings in immediately cured COVID-19 patients with nasal fractures: A retrospective study코 골절로 즉시 치료된 COVID-19 환자의 외부 부목과 비강 내 패킹에서 확인된 장기간의 바이러스 배출: 후향적 연구Article Published on 2022-06-012022-09-11 Journal: Journal of stomatology, oral and maxillofacial sur [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% confidence interval age association Asymptomatic Cohort COVID COVID-19 COVID-19 patient COVID-19 patients cured Fracture Gender Hospital stay humans Infection intranasal level 1 Linear regression model Multiple multiple linear regression models nasal Nasal fracture Odds ratio operative Other outcome parameter Patient patients Pearson Prolonged prolonged viral shedding Re-infection reached repair retrospective cohort study Retrospective study Sample size SARS-CoV-2 separated severity statistical significance surgical surgical site symptomatic Transmission trauma treated Treatment variable viral shedding [DOI] 10.1016/j.jormas.2022.04.003 PMC 바로가기 [Article Type] Article
Effect of ArtemiC in patients with COVID-19: A Phase II prospective studyClinical Trial Published on 2022-06-012022-10-04 Journal: Journal of Cellular and Molecular Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] adverse event Anti-inflammatory anti-SARS-CoV-2 ArtemiC Artemisinin blood test COVID-19 COVID-19 patient COVID-19 patients curcumin. Cytokine storm Day Decline Deterioration double-blinded Effect effective Efficacy and safety evaluated Fever hospital discharge Hospitalized Intensive lineages new SARS-CoV-2 NEWS2 oxygen supplementation Patient patients with COVID-19 PCR pharmacological phase Physical examination Placebo placebo-controlled Prospective Study Randomized receive reported SARS-CoV-2 standard care symptomatic those with comorbidities unmet need vaccination efficacy vital sign Vitamin Vitamin C was performed [DOI] 10.1111/jcmm.17337 PMC 바로가기 [Article Type] Clinical Trial