Vaccine design

[키워드] 2003 acute respiratory syndrome addition Administered Antisera bat bats Bearing candidate vaccine caused Cell cellular immune responses center characterized chimeric China Cluster coding Complete Consequences Control coronavirus cross death death rate death rates develop died different disease effective Efficacy eight elicit Epidemic etiological agent examined expressing finding flu found future infection Gene genetic material genetics glycoprotein group Guidance Heterologous heterologous challenge homologous homologous or heterologous homologous strain challenge Human human airway epithelial humans identify immune response immunized immunopathology infect Infected Infection information injected lung mice much higher neutralization nucleocapsid Older Outbreaks Particle pathological change pathology peaked phylogenetic analyses populations PROTECT Protein Proteins provide provided recombinant related virus related viruses replicated researcher reservoirs resource robust rodents S glycoprotein SARS Coronavirus SARS infection SARS virus SARS-CoV SARS-CoV N SARS-CoV S SARS-CoV S protein SARS-CoV vaccine SARS-CoV virus senescent severe severe pneumonia spike spike glycoprotein Spread strain Strains tested the disease the vaccine thought vaccination Vaccine vaccine candidate Vaccine design Vaccine development Vaccines variant Venezuelan equine encephalitis virus virus virus strain was used Web West Nile Virus World Health Organization zoonosis zoonotic
[DOI] 10.1371/journal.pmed.0030525 PMC 바로가기 [Article Type] Research Article