Protocol: Leveraging a demographic and health surveillance system for Covid-19 Surveillance in rural KwaZulu-NatalStudy Protocol Published on 2020-08-252022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] affecting Care Cohort collected data conducted coronavirus disease COVID-19 Critical Disease surveillance effort Epidemic Epidemics Epidemiology Health Health and Demographic Surveillance System HIV individual Intervention lack Local NPI outbreak pandemic Population positive Prevalence protocol Questionnaires resources risk Screening South Africa structures Support Surveillance the epidemic Tuberculosis unique [DOI] 10.12688/wellcomeopenres.15949.2 PMC 바로가기 [Article Type] Study Protocol
Impact of Shenfu injection on a composite of organ dysfunction development in critically ill patients with coronavirus disease 2019 (COVID-19): A structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-08-242022-10-29 Journal: Trials [Category] COVID-19, MERS, [키워드] 1:1 28-day mortality 48 hours adopted allergic allergy allocation concealment alveolar baseline bleeding blinded Blinding block randomization both group breastfeeding women caused China Chinese clinical clinical trial conducted control group coronavirus disease COVID-19 criteria Critical Critically ill patient death defined determine Diagnosis dissemination distribution element enrolled enrolment event exacerbated expected HIV hospital hospital cost ICU immunosuppressive drug Impact incidence include increase in injection intensive care Length lung malignant tumor management guideline multicenter National Health Commission number objective Obstructive Open-label organ organ dysfunction Organ failure outcome parallel group participant Patient patient recruitment patients patients with COVID-19 Pneumonia pregnant primary endpoint protocol provided pulmonary interstitial fibrosis random randomised randomised controlled trial randomization Randomized Randomized controlled trial Randomly receive recruit recruited researchers Sample size SAS sealed secondary endpoint Sepsis Seven severe malnutrition severity Shenfu injection shown SOFA SOFA score statistical status study group Study protocol supportive therapy the patient Total treat Treatment Two-arm underlying disease usual care vasoactive drug Volume website [DOI] 10.1186/s13063-020-04677-5 PMC 바로가기 [Article Type] Letter
Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trialsLetter Published on 2020-08-242022-10-29 Journal: Trials [Category] Coronavirus, MERS, [키워드] administration Analysis ARMS asked assessment Characteristics Chinese clinical trial Comparator group comparison Corticosteroid COVID-19 Critically ill patient defined Dexamethasone disease severity dissemination dose Effect element eligible EudraCT Evidence greater group heterogeneity High dose Hydrocortisone information Interaction Intervention intervention effect intervention group investigator ISRCTN less low dose meta-analyses Meta-analysis meta-regression Methylprednisolone Mortality Network meta-analysis objective Odds ratio Open-label outcome p-values participant Patient per day Placebo placebo-controlled primary analysis Prospective protocol provided quantified random-effect randomised controlled trial randomization Randomized Randomized controlled trials randomized trial Research Risk of bias RoB 2 secondary Serious Adverse Events Standard of care steroid Study protocol subgroup subgroups systematic review the WHO therapeutic dose therapy Treatment Trial trials usual care website WHO [DOI] 10.1186/s13063-020-04641-3 PMC 바로가기 [Article Type] Letter
Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico MethodArticle Published on 2020-08-232022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] applied approach approved candidate caused COVID-19 database drug Drug repurposing drug target global public health in silico inhibitor inhibitors Interaction ISM main protease Mpro molecular docking novel outbreak protocol repurposing SARS-CoV-2 SARS-CoV-2 main protease small molecule transmission rate Vaccine viral replication Virtual screening was used [DOI] 10.3390/molecules25173830 PMC 바로가기 [Article Type] Article
A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization매우 특이적이고 민감한 혈청학적 분석은 중화와 상관관계가 있는 COVID-19 환자의 SARS-CoV-2 항체 수준을 감지합니다Original Paper Published on 2020-08-212022-09-10 Journal: Infection [Category] MERS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition anti-SARS-CoV-2 antibody antibodies antibody Antibody test antigens Assay validation controls coronavirus correlated correlation COVID-19 COVID-19 patient cross-react described detect develop domain ectodomain ELISA enzyme IgA IgG immunosorbent Infection infection rate infection rates infections monitoring national health system neutralization objective pandemic parameter Patient protective immunity protocol public health measure public health measures R 2 RBD RBD ELISA RBD-based ELISA Receptor binding domain respiratory response Result robust S protein SARS-CoV-2 SARS-CoV-2 antibody seasonal coronaviruses sensitivity sera Seroconversion Serological assay serology Seroprevalence serum severe acute respiratory syndrome Coronavirus specificity Spike protein supplementary material symptom onset the RBD threshold thresholds vaccination Virus neutralization were measured [DOI] 10.1007/s15010-020-01503-7 PMC 바로가기 [Article Type] Original Paper
The efficacy and safety of fire needle therapy for COVID-19 Protocol for a systematic review and meta-analysis4900 Published on 2020-08-212022-10-30 Journal: Medicine [Category] COVID-19, MERS, [키워드] article Biological CBM China Chinese CNKI coronavirus Coronavirus disease 2019 COVID-19 CRD Data analysis database de-duplication Descriptive analysis effective Efficacy and safety evaluate fire fire needle identify Infrastructure Intervention Medicine Meta-analysis outbreak Patient performed Periodical Pneumonia prevention of COVID-19 protocol Randomized controlled trial reported review Safe searched subgroup analysis systematic systematic review therapeutic interventions therapy therapy for COVID-19 Treatment VIP Web of Science Wuhan, China [DOI] 10.1097/MD.0000000000021873 PMC 바로가기 [Article Type] 4900
Coronavirus discovery by metagenomic sequencing: a tool for pandemic preparednessArticle Published on 2020-08-212022-11-01 Journal: Journal of Clinical Virology [Category] COVID-19, MERS, SARS, [키워드] Amino acid assist bioinformatics capture Centrifuge classification clinical sample clinical samples clinical setting Combination contribute coronavirus Coronaviruses Coverage COVID-19 database detective diagnostic example genome coverage humans identity infect Laboratory MERS-CoV metagenomic metagenomic sequencing metagenomics NGS Novel coronavirus nucleotide pandemic probe protocol Result SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic sequencing depth the SARS-CoV-2 genome virus virus discovery viruses was tested [DOI] 10.1016/j.jcv.2020.104594 PMC 바로가기 [Article Type] Article
Respiratory Syndrome Coronavirus Infections: Possible Mechanisms of Neurological Implications—A Systematic ReviewNeurology Published on 2020-08-212022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] acute respiratory syndrome airway epithelia alveolar animal model Cell culture Central nervous system China CNS conducted Contact coronavirus CoV COVID-19 CoVs database Effect Encephalitis Factor globe healthy healthy individuals highlight immunized implication infecting Infection information knowledge manifestation mechanism molecular neurological manifestation neuronal neurovirulence other coronavirus outcomes pandemic pathogenicity Patient patients PICO prognostic protocol recruitment Regulated cell death reported respiratory respiratory tract Result review SARS-CoV2 Spread subsequent susceptible systematic review Transport virulence virus [DOI] 10.3389/fneur.2020.00864 PMC 바로가기 [Article Type] Neurology
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil – study protocolOriginal Article Published on 2020-08-212022-10-31 Journal: Clinics [Category] COVID-19, MERS, SARS, [키워드] Admission Analysis artificial Brazil Characteristics cohort study collected Comorbidities conducted coronavirus disease COVID-19 COVID-19 patients Cox proportional hazard Critically ill patient demographics electronic medical records epidemiological data Health hospital ICU identify include intensive care intensive care units investigator Kaplan-Meier curve large sample Latin America Mortality outcome pandemic Patient patients with COVID-19 protocol resource risk factor SARS virus Severe acute respiratory syndrome Severity of disease study period Study protocol Support survival university hospital Ventilation ventilator parameter with COVID-19 [DOI] 10.6061/clinics/2020/e2294 PMC 바로가기 [Article Type] Original Article
The Potential Role of Heparin in Patients With COVID-19: Beyond the Anticoagulant Effect. A ReviewPharmacology Published on 2020-08-212022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Activation acute respiratory distress acute respiratory syndrome anticoagulation antiviral drug approved clinical manifestations clinical trial clinical trials coagulation cascade Coagulopathy coronavirus COVID-19 death disease dose Effect effective Efficacy heparin Hospitalized hypercoagulability IMPROVE Infection microthrombus multi-organ failure no symptom organ outcome patients pleiotropic pleiotropic activity Potential progression prophylactic dose protocol reduce responsible resulting review risk role SARS-CoV-2 Septic shock severe pneumonia subjects supported supportive care Symptomatic treatment syndrome the disease to define Treatment unfractionated heparin [DOI] 10.3389/fphar.2020.01307 PMC 바로가기 [Article Type] Pharmacology