Coronavirus disease (COVID-19) outbreak and phase 1 trials: should we consider a specific patient management?Research article Published on 2020-09-012022-10-05 Journal: European journal of cancer (Oxford, England : 1990 [Category] SARS, 임상, [키워드] Care clinical trial COVID-19 disease Drug development Drug efficacy enrolled Healthcare system Intensive key factor management outbreak pandemic Patient patient selection patients Patients with cancer Perspective Phase 1 phase 1 trial raised Research risk SARS-CoV-2 Toxicity trials [DOI] 10.1016/j.ejca.2020.07.009 [Article Type] Research article
Managing oncology clinical trials during COVID-19 pandemicResearch article Published on 2020-09-012022-10-05 Journal: Contemporary Clinical Trials Communications [Category] 임상, [키워드] clinical trial COVID-19 COVID-19 pandemic Critical drug Follow-up food Health help management managing oncology Oncology clinical trials participant Patient patient safety recommendation Research Trial [DOI] 10.1016/j.conctc.2020.100637 [Article Type] Research article
Debate on Bacille Calmette-Guérin vaccination against COVID-19: Is it worth performing clinical trials?Correspondence Published on 2020-09-012022-10-05 Journal: Biosafety and Health [Category] 임상, [키워드] approved drug bacille Calmette-Guérin BCG BCG vaccination caused Clinical improvement clinical trial COVID-19 death debate Effect Effectiveness evaluate Immunity individual Infectious disease no significant effect non-specific Non-specific effect Pandemics provide Randomized controlled trial RCT reduction in respiratory infection Respiratory pathogens Sample size severe coronavirus disease specific treatment therapy Transmission vaccination Vaccine [DOI] 10.1016/j.bsheal.2020.07.001 [Article Type] Correspondence
Immunoregulation with mTOR inhibitors to prevent COVID-19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicinesCOVID-19 중증도를 예방하기 위한 mTOR 억제제를 사용한 면역 조절: 백신 및 특정 항바이러스제를 넘어선 새로운 개입 전략Article Published on 2020-09-012022-09-12 Journal: Journal of medical virology [Category] 진단, [키워드] Activation acute respiratory syndrome ADE Antibody-dependent enhancement antiviral medicine Characteristics clinical trial coronavirus Coronavirus disease 2019 COVID-19 CoVs Critical Critically ill patient cross-reactive cross-reactive antibody cytokine Cytokine storm Cytokine storms death develop drug early stage effective global public health high-risk patient highly pathogenic human coronavirus Immunity inhibited inhibitor Intervention mammalian memory B cell more difficult Mortality mortality rate mTOR inhibitor mTOR inhibitors Occurrence Prevent prevented Rapamycin reduce reducing severe symptom severity severity of COVID-19 the disease Vaccine virus [DOI] 10.1002/jmv.26009 PMC 바로가기 [Article Type] Article
Inclusion of pregnant women in clinical trials of COVID-19 therapies: what have we learned?Correspondence Published on 2020-09-012022-10-05 Journal: British journal of anaesthesia [Category] SARS, 임상, [키워드] clinical trial COVID-19 Drug development Pregnancy pregnant women randomised controlled trial [DOI] 10.1016/j.bja.2020.05.020 [Article Type] Correspondence
The SARS-CoV-2 pandemic impact on rhinology research: A survey of the American Rhinologic SocietySARS-CoV-2 대유행이 비과학 연구에 미치는 영향: 미국 비뇨기과학회 조사Article Published on 2020-09-012022-09-11 Journal: American journal of otolaryngology [Category] SARS, 비임상, [키워드] approval basic Basic science breath Care cell line change changes in clinical Clinical research clinical trial clinical trials Community coronavirus COVID COVID-19 COVID-19 pandemic cross-sectional cross-sectional study employment Enrollment evaluated faster globe healthcare hospital identify impacted in vitro study Laboratory lifted maintaining majority mitigate MOST pandemic participant Research resident Resident education response rate response rate) rhinology Safe SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 virus Society Spread Support the SARS-CoV-2 virus Trial universities virus [DOI] 10.1016/j.amjoto.2020.102617 PMC 바로가기 [Article Type] Article
How a Psychopharmacology Clinical Trial Site in the Seattle Area Managed Clinical Trials and Patient Care During the COVID-19 PandemicShort communication Published on 2020-09-012022-10-05 Journal: The American journal of geriatric psychiatry : official journal of the [Category] SARS, 임상, [키워드] addition Area Blood oxygen saturation Care center clinical clinical trial clinical trials Control coronavirus COVID-19 COVID-19 pandemic Dementia Elderly patient greater Health higher risk individual Isolation objective Patient patients physician potential risk Psychopharmacology Pulse oximeter pulse oximetry recommendation recommendations remained Research Result Seattle Site Symptoms temperature transfer trials [DOI] 10.1016/j.jagp.2020.06.012 [Article Type] Short communication
Prediction of respiratory decompensation in Covid-19 patients using machine learning: The READY trialResearch article Published on 2020-09-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 임상, [키워드] Algorithm Care clinical trial COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients COVID-19 positive patients decompensation demonstrated diagnostic enrolled evaluated False positive FIVE health system help initial intubation Invasive mechanical ventilation machine machine learning mechanical ventilation multicenter Odds ratio offer Patient patients physician predict prediction Prevent Prognosis resources Result score scoring system sensitivity significantly higher specificity Trial United State Ventilation [DOI] 10.1016/j.compbiomed.2020.103949 [Article Type] Research article
COVID-19: Review on latest available drugs and therapies against SARS-CoV-2. Coagulation and inflammation cross-talkingReview article Published on 2020-09-012022-10-05 Journal: Virus research [Category] SARS, 비임상, 치료제, [키워드] amplification Anakinra Baricitinib clinical trial Coagulation Coagulopathy coronavirus Corticosteroid COVID-19 Cytokine storm Dexamethasone drug drugs eculizumab emapalumab heparin Human implicated include Infection Inflammation inflammatory phase Lopinavir/ritonavir mild infection Remdesivir response responsible review ruxolitinib SARS-CoV-1 SARS-CoV-2 Severe case severe cases suggested therapeutic option Therapies therapy Tocilizumab Treatment [DOI] 10.1016/j.virusres.2020.198070 [Article Type] Review article
Does hereditary angioedema make COVID-19 worse?Review article Published on 2020-09-012022-10-05 Journal: The World Allergy Organization Journal [Category] 변종, [키워드] Abnormalities ACE2 acute respiratory syndrome aggravate angiotensin-converting enzyme 2 Asymptomatic carrier attack cells clinical trial Comorbidity complement complement system Contact contact system coronavirus coronavirus disease COVID-19 COVID-19 progression cytokine release deplete Disease activity favor HAE hematologic Hereditary angioedema host cell Hypothesis induce Inflammation inhibitor Interaction Lung injury mechanism medication metabolism mutations outcomes pandemic Pathogenesis pathophysiologic Patient performed Prophylactic Prophylaxis receptor risk SARS-CoV-2 SARS-COV-2 infection Spread T helper therapeutic strategy Treatment turn [DOI] 10.1016/j.waojou.2020.100454 [Article Type] Review article