Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Research Article
[키워드] 50% effective concentration
absence
acute respiratory syndrome
animal model
Antiviral
Antiviral agents
antiviral resistance
approved
attenuate
Combined
Concentration
conserved
coronavirus
CoV
CoV infection
CoVs
decrease
development
effective
Efficacy
ExoN proofreading
Exoribonuclease
expand
GS-5734
human infections
humans
impair
in vitro
include
Infection
infections
inhibit
interfere
Mediated
MERS-CoV
MHV
Middle East
murine hepatitis virus
mutant
Mutation
nontoxic
Nsp12
nsp14 exoribonuclease
nucleoside
nucleoside analogs
nucleotide prodrug
overcome
pandemic
parent nucleoside
passage
Pathogenesis
phenotype
polymerase
Proofreading
PROTECT
Remdesivir
reported
residue
respiratory syndrome coronavirus
RNA polymerases
SARS-CoV
selected
severe disease
significantly more
Substitution
therapeutic
treat
viral fitness
virulence
virus
wild-type
zoonotic CoV
[DOI] 10.1128/mBio.00221-18 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mBio.00221-18 PMC 바로가기 [Article Type] Research Article