clinical trial – Page 217 – Communicable Diseases Research

Vaccine Candidates against Coronavirus Infections. Where Does COVID-19 Stand?

Review

Published on 2020-08-072022-10-28
Journal: Viruses [Category] COVID-19, MERS,

Will Hydroxychloroquine Still Be a Game-Changer for COVID-19 by Combining Azithromycin?

Hydroxychloroquine은 여전히 Azithromycin을 결합하여 COVID-19에 대한 게임 체인저가 될 것입니까?

Review

Published on 2020-08-072022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 비임상,

Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past

Immunology

Published on 2020-08-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] acute phase against SARS-CoV antibody production association attack B cell caused classical clinical trial combating complexes component contagious convalescent plasma coronavirus Coronaviruses correlated COVID-19 COVID-19 patients cross-reactivity cytokine cytokine secretion cytolytic develop disease disease severity downregulated drug expression flu Genome sequencing group help highlight HIV HLA Host identify IFNs IL-6 immune response Immunotherapy induce infected individual infected individuals Infection Influenza initiated interferon lesson limitation Local lymphopenia malaria memory memory T cell MERS MERS-CoV MHC MHC allele MHC alleles MHC presentation molecular neutralization neutralizing antibody Novel coronavirus nucleocapsid protein pandemic pathogenicity Plasma transfusion Pneumonia polymorphism populations preventive measures protective response Rapid recovered patient reported researcher Respiratory system response resulting SARS-CoV-2 similarity specific treatment Stage Symptom T cell epitope T cells T-cell TNF-α Treatment treatment strategy Tuberculosis Type Viral antigen viral infection Viremia virus virus particle
[DOI] 10.3389/fimmu.2020.01949 PMC 바로가기 [Article Type] Immunology

Medical research during the COVID-19 pandemic

COVID-19 전염병 동안 의료 연구

Review

Published on 2020-08-062022-09-11
Journal: World J Clin Cases [Category] 비임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 affected approach best breath Care caused clinical clinical experience clinical trial Clinical trial design clinical trials collaboration Complete conduction Contact contact with contagiousness coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 pandemic Critical deaths experimental animal models flexible Follow-up Health Health care hospitals identify implementation in vitro include infections initiated involved Laboratory long term Medical research medical staff medication mental health Modification modifications MOST Novel coronavirus number of deaths pandemic participant Patient physical positive patients professional reason reported Research respiratory retroviral rights running sample sizes SARS-CoV-1 SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specific treatment spread to suggested survivor therapy today Treatment Trial vaccination virus viruses with COVID-19 Wuhan Wuhan, China
[DOI] 10.12998/wjcc.v8.i15.3156 PMC 바로가기 [Article Type] Review

A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19

Remdesivir에 대한 검토: COVID-19 치료를 위한 잠재적인 약제

Review

Published on 2020-08-062022-09-11
Journal: Drug design, development and therapy [Category] 비임상,

[키워드] (RdRp 2019-nCoV active form acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine adenosine triphosphate agent animal model animal models ATP breath cause caused Characteristics clinical trial clinical trials competing coronavirus COVID-19 demonstrated development disease drug Ebola virus effective effective therapy Efficacy epithelial cells Google Scholar GS-5734 Human in vitro In vitro studies in vitro study information inhibit management MERS MERS coronaviruses Novel coronavirus nucleoside nucleoside triphosphate phosphoramidate prodrug RdRP Remdesivir respiratory respiratory epithelial cell respiratory epithelial cells review RNA RNA polymerase RNA-dependent RNA polymerase SARS and MERS coronaviruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus time-consuming treat Treatment treatment of COVID-19 Vaccine Viral viral replication Viral RNA viral RNA-dependent RNA polymerase
[DOI] 10.2147/DDDT.S261154 PMC 바로가기 [Article Type] Review

A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting Leukotrienes

Pharmacology

Published on 2020-08-062022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] activity acute respiratory distress Airway inflammation ARDS Atypical Case report Clinical course clinical trial coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 progression Cytokine storm dead Dexamethasone Disease progression drug drugs targeting global pandemic host responses Hyperinflammatory hypoxic respiratory failure immune Immune cell indicated infecting Inflammatory response knowledge leukotriene leukotrienes lipid mediator Mild mitigate Multiorgan new virus novel offer Organ failure other coronavirus potential mechanism progression receptor Remdesivir response Result SARS-CoV-2 similarity Strategy syndrome targeting thrombotic complication Treatment Vascular vascular leak vascular leakage virus
[DOI] 10.3389/fphar.2020.01214 PMC 바로가기 [Article Type] Pharmacology

Long‐term safety and efficacy of lanreotide autogel in Japanese patients with neuroendocrine tumors: Final results of a phase II open‐label extension study

Original Article

Published on 2020-08-052024-09-04
Journal: Asia-Pacific journal of clinical oncology [Category] 대상포진,

[키워드] clinical trial Japanese lanreotide neuroendocrine tumor Somatostatin
[DOI] 10.1111/ajco.13371 PMC 바로가기 [Article Type] Original Article

Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats

Research Article

Published on 2020-08-052022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

Directly Acting Antivirals for COVID-19: Where Do We Stand?

Microbiology

Published on 2020-08-052022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] Acidic acting Antiviral antivirals approved Case series case sery Characteristics Chinese clinical clinical trial clinical trials conducted coronavirus disease COVID-19 drug Evidence examined Favipiravir genomic identify include influenza infections information inhibitor inhibitors management Novel coronavirus observational studies Other outbreak pandemic pathogenic mechanism polymerase Protease inhibitor randomized controlled study rapid review Registered registry Remdesivir reported required RNA-dependent RNA polymerase SARS-CoV-2 systematic review therapeutic treat umifenovir while Wuhan, China
[DOI] 10.3389/fmicb.2020.01857 PMC 바로가기 [Article Type] Microbiology

Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis

Medicine

Published on 2020-08-042022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] accelerate Accuracy Analysis calculated candidate clinical trial clinical trial registry Cochrane Library collected conducted coronavirus COVID-19 COVID-19 diagnosis COVID-19 patients Diagnosis diagnostic diagnostic tests disease duplicates eligible Escalation gold standard Handbook heterogeneity IMPROVE infected individual Meta-analysis moderate Nasopharyngeal swab NPs offer Positive test proportion quantitative synthesis raw data Registered reliability reported Saliva saliva specimens saliva test SARS-CoV-2 SARS-CoV-2 viral RNA searched sensitivity specificity suggested systematic review virus Web of Science
[DOI] 10.3389/fmed.2020.00465 PMC 바로가기 [Article Type] Medicine