Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus InfectionResearch Article Published on 2010-01-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 2B4 cell 2B4 cells Activation aggravate antiviral genes antiviral signaling bronchial bronchial epithelial cell calu-3 cells cellular cloned complementary complex coronavirus detected detrimental dynamic epithelial epithelial cell line event expression found functional growth highlight Host Human identify IFN-stimulated gene IFN-β IFN-λ Immune-mediated Infected Inflammatory cytokine Inflammatory mediators Inflammatory responses Innate interferon interferon regulatory factor ISGs limit lung epithelial cell Lungs nuclear pathology post infection Protein Replication respiratory response resulting SARS pathogenesis SARS-CoV SARS-CoV infection secreting severe Signaling Support target these cell triggered [DOI] 10.1371/journal.pone.0008729 PMC 바로가기 [Article Type] Research Article
Crystal Structure of the C-Terminal Cytoplasmic Domain of Non-Structural Protein 4 from Mouse Hepatitis Virus A59Research Article Published on 2009-07-102022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Amino acid asymmetric unit C-terminal complex conformation conserved coronavirus Coronavirus replication crystal crystal structure cytoplasmic cytosol determined different dissociate disulfide bond domain Endoplasmic reticulum ER membrane expressed feature finding functional hydrophilic infected cells membrane membrane vesicle MHV monomer mouse mutant N- and C-termini non-structural proteins not affect Nsp3 nsp4 opposite physiological recruited reducing Region Replication Ser shown Structure wild-type [DOI] 10.1371/journal.pone.0006217 PMC 바로가기 [Article Type] Research Article
A computational analysis of SARS cysteine proteinase-octapeptide substrate interaction: implication for structure and active site binding mechanismResearch Published on 2009-01-302022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, [키워드] approach binding binding mechanism carried complex computational analysis contribute cysteine drug design electrostatic enzyme Hypothesis involved MD simulation MD simulations molecular molecular docking proteinase Replication Research residue respiratory Result SARS Coronavirus severe shown turn understanding virus α-helix [DOI] 10.1186/1471-2105-10-S1-S48 PMC 바로가기 [Article Type] Research
Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell DeterminantResearch Article Published on 2008-10-242022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] alteration amino acid substitution analysis antigen-specific T cell association Author CD8+ T cell changes in clinical disease complex Complex molecule conformation Consensus Critical CTL cytotoxic determinant Disease progression Diseases elicit Enhancing epitope escape expressed functional Hepatitis histocompatibility HIV immune response immune responses immunodominant Infected Local Major memory MHC class I mice molecular basis motif mouse hepatitis mutated Mutation natural infection occur pathogen peptide performed prevention PROTECT Protective recombinant residue response significantly higher stability Subdominant T cell T cell epitope T cell response tumor immunity Vaccine development viral infection virus virus wildtype [DOI] 10.1371/journal.ppat.1000186 PMC 바로가기 [Article Type] Research Article
Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV ReplicationResearch Article Published on 2008-10-012022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adopted assays biochemical complex coronavirus coronavirus Coronavirus replication detected domain expressing found function in vitro Interaction Involvement mammalian mechanism molecular mechanisms multifunctional Nidovirale non-structural protein Nsp12 nsp14 Nsp3 platform Protein protein-protein interaction Proteins provided regulate reporter RNA genome SARS Coronavirus SARS-CoV sequence shown stimulated to screen Transcription unique Viral protein viruses [DOI] 10.1371/journal.pone.0003299 PMC 바로가기 [Article Type] Research Article
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic ReticulumResearch Article Published on 2008-09-162022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] acute respiratory syndrome alteration Analysis Antiviral applied arising Author biochemical characterized complex connection coronavirus coronavirus cytoplasm cytosol Defense defined dissect double-stranded RNA driven by early stage electron tomography Endoplasmic reticulum endoplasmic reticulum membrane enzyme ER membrane host cell host cell membrane host cell membranes host cells human pathogen implicated in viral induce Infected infected cell interior invagination mechanism mechanisms membrane membrane-bound membranes Microscopy network question raise replicate Replication replication complex replicative protein reported Reticulum reveal RNA RNA genome RNA synthesis RNA virus RNA viruses SARS-coronavirus SARS-CoV Structure subunits Support thought tomography ultrastructure unique Vesicle vesicles viral replication viral RNA synthesis virus Virus-host interactions Web [DOI] 10.1371/journal.pbio.0060226 PMC 바로가기 [Article Type] Research Article
Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 ActivationResearch Article Published on 2008-06-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation ADP-ribosylation Analysis ARF ARF1 association Author cells cellular cellular pathway characteristic complex connection coronavirus coronavirus Coronavirus replication Critical demonstrated dominant-negative downstream Endoplasmic reticulum Express expression Factors GBF1 GTPase GTPases guanine Host Human induce infected cell Infection inhibited inhibiting interfere involved knockdown MDCK cells membrane MHV Microscopy mouse mouse hepatitis mutant nucleotide observation provide Quantitative reduced Replication replication complex required RNA RNA virus secretory pathway significantly siRNA siRNAs structures target vesicles viruses [DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In VitroResearch Article Published on 2008-05-022022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activity acute respiratory syndrome addition Author cause centrifugation characteristic complex complexes connection Critical cytoplasm cytoplasmic Degradation dependent on develop digestion dissect eight enzyme Enzymes Factor fraction functional genomic RNA Host host cell membranes host cells in vitro in vitro activity Infected infected cell life-threatening membrane membrane structure membrane structures membranes non-structural protein NSP Nsps polyproteins precursor produced protease PROTECT protein synthesis released remained replicate Replication required RNA RNA synthesis robust RTC SARS-coronavirus SARS-CoV SARS-CoV-infected cells Structure subgenomic mRNA subgenomic mRNA synthesis subunit susceptible Transcription Treatment viral genome replication Viral RNA viral RNA synthesis virus-induced membrane structure virus-induced membrane structures [DOI] 10.1371/journal.ppat.1000054 PMC 바로가기 [Article Type] Research Article
Analysis of Intraviral Protein-Protein Interactions of the SARS Coronavirus ORFeomeResearch Article Published on 2007-05-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute respiratory syndrome Analysis Characteristics cloned complex coronavirus deleted different displaying expected expression function functional Genome genome-wide analysis growth in vitro interact Interaction interactions mammalian cells non-structural protein Nsp12 nsp13 nsp14 NSP2 Nsp9 open reading frames ORF Orf9b ORFeome pathogenicity performed positive predicted Protein protein interaction Proteins proteome Replication SARS-CoV shown stability tested Vero cells Viral proteins viral replication virus [DOI] 10.1371/journal.pone.0000459 PMC 바로가기 [Article Type] Research Article
Human immunopathogenesis of severe acute respiratory syndrome (SARS)Article Published on 2007-03-192022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Adaptive immune response cellular chemokine Clinical course Complete complex cytokine dysregulated hallmark Host host immune system host immunity host response Human human host hypercytokinemia IFN Immunity immunological Immunopathogenesis immunopathology Impact imperative Infected infectious Inflammatory response Injury Innate immunity interferon mechanism Microarray molecular morbidity Progressive Protective Research response resulting SARS SARS Coronavirus SARS CoV SARS patients severe pathology severe SARS suggested systematic analysis type I [DOI] 10.1016/j.virusres.2007.02.014 PMC 바로가기 [Article Type] Article