Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies
로피나비르에 대한 임신초기 노출(다루나비르 아님)은 탈락막화를 손상시킵니다: HIV 양성 임신에서 출산 결과가 좋지 않을 수 있는 잠재적 기전
Article
[키워드] Activation
Administered
Affect
age
alteration
Analysis
Angiogenesis
animal model
Antiretroviral therapy
approval
Biomarker
Biomarkers
biopsy
birth outcomes
breath
cART
cause
caution
Cell
Cell culture
cells
chance
clinical implications
clinical trial
clinical trials
clinically
co-culture
Combination
complement
Complement activation
conception
contributing to
correlation
COVID-19
COVID-19 pandemic
Culture
culture system
current
darunavir
decidualization
decrease
drug candidate
Drug safety
dysregulation
early pregnancies
early pregnancy
early stage
early stages
Effects
Efficacy
ELISA
evaluate
evaluated
event
Evidence
evidence of
Ex vivo
experimental models
expression
Factor
Factors
female
first trimester
flow cytometry
for inclusion
foundation
funding
gestational age
Health care
Health care worker
health care workers
healthy
highest
highlight
HIV
HIV infection
HIV protease inhibitor
HIV protease inhibitors
immune cell population
immune cell populations
immune dysregulation
Immunohistochemical analysis
immunohistochemistry
impair
impairment
implication
in vitro
in vivo
include
Inflammation
initiated
lack
leads
Lopinavir
Luminex assay
Lye
matter
maturation
mechanism
media
mice
Migration
modify
mouse
natural killer
Natural killer cells
offered
once daily
outcome
outcomes
Participation
placental
placentation
potential mechanism
pregnancies
Pregnancy
pregnant women
prophylactically
protease
PROTECT
quantified
reduced
regimen
regulate
reported
reproductive
resource
Respiratory disease
sacrifice
Safe
selective
specific effect
specific effects
spiral
spiral artery
spiral artery remodeling
STAT3
Stephen
Support
supported
TANK
termination of pregnancy
therapeutic potential
Think tank
tissue
transcription factor
Transgender
Treatment
Trial
trophoblast
trophoblasts
uterine
uterine natural killer cells.
Vascular
viability
was measured
was obtained
was used
water
were used
with HIV
women
[DOI] 10.1093/humrep/deaa151 PMC 바로가기 [Article Type] Article
[DOI] 10.1093/humrep/deaa151 PMC 바로가기 [Article Type] Article