accelerate – Page 22 – Communicable Diseases Research

Combined drug repurposing and virtual screening strategies with molecular dynamics simulation identified potent inhibitors for SARS-CoV-2 main protease (3CLpro)

분자 역학 시뮬레이션과 결합 된 약물 재검사 및 가상 스크리닝 전략 SARS-COV-2 주요 프로테아제 (3CLPRO)에 대한 강력한 억제제를 확인했습니다.

Article

Published on 2021-08-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발,

Collaborative Platform Trials to Fight COVID-19: Methodological and Regulatory Considerations for a Better Societal Outcome

COVID-19 퇴치를 위한 협업 플랫폼 시도: 더 나은 사회적 결과를 위한 방법론 및 규제 고려 사항

Review

Published on 2021-08-012022-09-11
Journal: Clinical Pharmacology and Therapeutics [Category] 신약개발, 임상, 치료제,

A look into the future of the COVID-19 pandemic in Europe: an expert consultation

Viewpoint

Published on 2021-07-302022-10-04
Journal: The Lancet Regional Health - Europe [Category] 변종,

Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease

Review

Published on 2021-07-302022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] accelerate ACE2 Activation acute respiratory syndrome addition Altered AMP-activated protein kinase (AMPK) AMPK angiotensin-converting enzyme (ACE) angiotensin-converting enzyme 2 Cell cell type cell types cells cellular homeostasis circular RNAs coronavirus Coronavirus Disease (COVID)-19 COVID-19 associated nephropathy COVID-19 patients COVID-19 severity Cytokine storm diabete diabetes Diabetic diabetic kidney disease dipeptidyl peptidase (DPP)-4 disrupt endothelial cells endothelial-to-mesenchymal transition endotheliopathy epithelial cells epithelial-to-mesenchymal transition expression facilitate fibrosis homeostasis Infection Injury interact kidney Kidney disease Kidney diseases lncRNAs Macrophage macrophages MAS1 mechanism microRNA MicroRNAs Neutrophils organ Organ failure pathogenic Platelets protective role Protein Proteins provided reaction receptor Replication resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Signaling stability standard care Support target therapy thrombus formation viral entry
[DOI] 10.3390/ph14080751 PMC 바로가기 [Article Type] Review

Vitamin D, infections and immunity

비타민 D, 감염 및 면역

Review

Published on 2021-07-292022-09-10
Journal: Reviews in Endocrine & Metabolic Disorders [Category] 유전자 메커니즘,

[키워드] β-defensin 2 25-hydroxyvitamin D accelerate Analysis Antibacterial antimicrobial peptide antimicrobial peptides Antiviral antiviral responses arising autophagy benefit best CAMP caries cascades Cathelicidin characterized condition COVID-19 COVID-19 crisis COVID-19 pandemic Critical CYP27B1 deficiency Dental caries disease severity Diseases downstream dysregulation epidemiological Evidence expression expression of gene greater handling Health identify Immune cell immune cells immune responses Immunity in some induce Infection Infectious diseases Inflammation Inflammatory bowel disease inflammatory bowel diseases innate immune innate immune response innate immune responses innate immune system intestinal flora intracellular pathogens knowledge Laboratory Local macrophages mechanism microbial Mortality NOD2 pathogen Pathogens Pattern recognition Pattern recognition receptors peptide peptides Poor promote provide reduce respiratory respiratory tract severity Signaling signaling cascade signaling cascades skeletal stimulate Strong susceptibility therapeutic intervention therapeutic interventions therapeutic potential Tuberculosis turn upstream Vaccines Viral viral infections Vitamin D vitamin D deficiency Vitamin D status Vitamin D supplementation
[DOI] 10.1007/s11154-021-09679-5 PMC 바로가기 [Article Type] Review

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Public Health

Published on 2021-07-282022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

[키워드] accelerate ACE2 ACE2 receptor Affect aggravate airways alveolar cells article ASL blood glucose carbohydrates Cell cell damage cell death cells Combination Complication computational modeling Concentration condition COVID-19 Critical care Cytokine storm database diagnostic disease disease severity dysregulated dysregulation Effect elevated Elevation evade Evidence explain facilitate feasibility Glucose glycemia glycemic control Glycolysis glycosylation hyper-inflammation hyperglycemia Hypothesis immune defense inactivation induce Infection infection process infections Inflammation information innate immune system involved Ketogenic diet knowledge Level lung Lungs machine learning model MOST multi-organ failure multiple mechanism pandemic potential treatments progression proportion provide pulmonary inflammatory response Quantitative reached replicate Replication Research risk role SARS-CoV-2 Severe case severe COVID-19 severity subsequent Symptoms tested the cytokine storm the disease the patient the SARS-CoV-2 Thrombotic events treatment strategy View viral infection Viral load virus weakened
[DOI] 10.3389/fpubh.2021.695139 PMC 바로가기 [Article Type] Public Health

Antiviral Therapeutic Approaches for SARS-CoV-2 Infection: A Systematic Review

Review

Published on 2021-07-282022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] accelerate adverse event Antiviral applied approved Arbidol carried Characteristics Clinical improvement conducted COVID-19 database demographic data drug drugs effective Efficacy Efficacy and safety Evidence Favipiravir FIVE groups help hospitalized patient IMPROVE in vitro study increased risk Intensive Intervention involved lack Lopinavir/ritonavir MERS other disease patients treated patients with COVID-19 Pub reducing mortality Remdesivir review ribavirin Safe Safety SARS-CoV SARS-CoV-2 significant difference Support symptom resolution systematic review Treatment umifenovir viral clearance with COVID-19 WoS
[DOI] 10.3390/ph14080736 PMC 바로가기 [Article Type] Review

An ultra-portable, self-contained point-of-care nucleic acid amplification test for diagnosis of active COVID-19 infection

활성 COVID-19 감염의 진단을위한 매우 포트 가능하고 자체 포함 된 시점 핵산 증폭 테스트

Article

Published on 2021-07-262022-09-01
Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술,

AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter

Update

Published on 2021-07-262022-10-04
Journal: Trials [Category] SARS, 임상,

[키워드] accelerate approved candidate clinical evaluation Cohort COVID-19 COVID-19 pandemic determine Dexamethasone dose drug early phase early stage Efficacy EudraCT evaluated flexible global healthcare healthy help Hospitalised patients identify information ISRCTN knowledge late phase later phase Master protocol National open label patients Phase I/II, Bayesian platform Platform study Platform trial primary endpoint protocol randomised randomised controlled trial recovery recruitment Remdesivir Safe Sample size SARS-CoV-2 SARS-COV-2 infection seamless Study protocol supplementary material Tocilizumab Treatment treatments for COVID-19 Trial trial platform trial protocol University of Oxford WHO
[DOI] 10.1186/s13063-021-05458-4 PMC 바로가기 [Article Type] Update

Application of Big Data and Artificial Intelligence in COVID-19 Prevention, Diagnosis, Treatment and Management Decisions in China

Systems-Level Quality Improvement

Published on 2021-07-242022-10-29
Journal: Journal of medical systems [Category] COVID-19, SARS,

[키워드] accelerate acute respiratory syndrome affected application artificial artificial intelligence automatically big data caused China Clinical features close contact computational analysis contribute coronavirus COVID-19 COVID-19 pandemic decision deep learning Diagnosis Disease progression effective emergency response Epidemic epidemic prevention and control event explain feasible identify IMPROVE Infection Infectious disease information intelligence lack management mechanism outbreak populations prevention problem provide public health Research SARS-CoV-2 shown source of infection Spread Support Surveillance Transmission Treatment Vaccine Vaccine development Vaccines Wuhan, China
[DOI] 10.1007/s10916-021-01757-0 PMC 바로가기 [Article Type] Systems-Level Quality Improvement