Enhanced External Counterpulsation as a Novel Treatment for Post-acute COVID-19 SequelaeInternal Medicine Published on 2021-04-072022-10-31 Journal: Cureus [Category] COVID-19, [키워드] activity acute COVID-19 acute infection acute phase acute respiratory syndrome cardiovascular diseases coronavirus coronavirus disease Counterpulsation COVID-19 eecp Effect enhanced enhanced external counterpulsation External fatigue FIVE Headaches Health knowledge Long COVID mechanism of action novel Pain pandemic PASC Patient patient reported predominant random reported resolved responsible SARS-CoV-2 SARS-COV-2 infection Shortness of breath Symptom the patient therapy Treatment virus [DOI] 10.7759/cureus.14358 PMC 바로가기 [Article Type] Internal Medicine
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severityObservational Study Published on 2021-04-062022-10-04 Journal: Infection [Category] MERS, SARS, 임상, [키워드] acute COVID-19 acute respiratory syndrome analyzed auto-antibody caused CD169 circulating monocyte clinical study coronavirus Coronavirus disease 2019 COVID-19 Defense described disease severity downstream evaluate expressed expression expression level IgG Infection interferon interferon signaling Mild Neutralizing Patient patients with COVID-19 SARS-CoV-2 Severe COVID-19 Infection severe disease SIGLEC1 Type type I interferon type I interferons viral infections [DOI] 10.1007/s15010-021-01606-9 PMC 바로가기 [Article Type] Observational Study
Acute and post-acute phase of COVID-19: Analyzing expression patterns of miRNA-29a-3p, 146a-3p, 155-5p, and let-7b-3p in PBMCComparative Study Published on 2021-04-062022-10-04 Journal: International immunopharmacology [Category] MERS, 바이오마커, [키워드] acute COVID-19 acute respiratory syndrome addition Analysis appear assays Biomarker cellular miRNA characteristic coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 patient COVID-19 patients COVID‐19 demonstrated Diagnosis diagnosis and monitoring disease evaluated expression level expression pattern groups healthy information microRNA miRNA miRNA expression miRNA profile mononuclear cell pathogen PBMC PBMCs Peripheral blood Real-time PCR Result ROC ROC analysis SARS-CoV-2 selected sensitivity significantly significantly higher specificity suggested the disease the healthy was tested [DOI] 10.1016/j.intimp.2021.107641 PMC 바로가기 [Article Type] Comparative Study
Distinct SARS-CoV-2 antibody reactivity patterns in coronavirus convalescent plasma revealed by a coronavirus antigen microarray코로나바이러스 항원 마이크로어레이로 밝혀진 코로나바이러스 회복기 혈장의 뚜렷한 SARS-CoV-2 항체 반응성 패턴Article Published on 2021-04-062022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] acute COVID-19 Adaptive immunity administration analyses Analysis analyzed antibody reactivity Antibody Response Antibody responses Antigen antigens array assays CCP chemiluminescence immunoassay clinical Clinical studies Cluster Clustering analysis collected Computational approaches Concordance convalescent plasma coronavirus COVID-19 case COVID-19 cases COVID-19 convalescent plasma Cutoff disease Donor Emergency use EUA FDA Generalized linear model Hierarchical Hierarchical clustering analysis Humoral immunity identify immunoassay Immunoglobulin IMPROVE Infection intensity MERS Microarray multiplex neutralization Neutralization assay offer plasma plasma sample plasma samples positive Predictive pseudovirus random Random forest reactive reactivity reactivity pattern recombinant proteins reporter Result SARS-1 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV2 serum specimen the SARS-CoV-2 therapeutic efficacy threshold thresholds Total total Ig training set Treatment vaccination vaccine immunogenicity Viral viral particle was used with COVID-19 [DOI] 10.1038/s41598-021-87137-7 PMC 바로가기 [Article Type] Article
Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children – a cross-sectional observational study from southern India.PIMS-TS, COVID-19 및 SARS-CoV2 혈청양성 아동의 혈장 바이오마커 프로파일링 - 인도 남부의 횡단면 관찰 연구.Observational Study Published on 2021-04-022022-08-31 Journal: EBioMedicine [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, [키워드] acute COVID-19 Analysis Biomarker Care CCL11 CCL19 CCL2 CCL20 CCL5 chemokine chemokines Chennai children Children's Hospital clinical phenotype clinical phenotypes conditions controls correlated country COVID-19 COVID-19 infection cross-sectional CRP CXCL10 cytokine Cytokine storm Cytokines elevated finding GM-CSF granzyme granzyme B growth factor Growth factors hospital Hyperinflammatory IFNα IFNβ IFNγ IL-1 IL-10 IL-15 IL-17A IL-1α IL-2 IL-33 IL-6 immune India Infection Inflammatory lymphocyte Lymphocyte count management MIS-C multiplex negative correlation paediatric inflammatory multisystem syndrome Pathogenesis performed PIMS PIMS-TS plasma biomarker positive correlation presenting pro-inflammatory cytokines SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 seropositive significantly sodium sodium levels syndrome TNFα trajectory unique VEGF [DOI] 10.1016/j.ebiom.2021.103317 PMC 바로가기 [Article Type] Observational Study
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort studyCOVID-19로 입원한 성인을 위한 ISARIC 4C 악화 모델의 개발 및 검증: 전향적 코호트 연구Multicenter Study Published on 2021-04-012022-09-06 Journal: The Lancet. Respiratory Medicine [Category] Communicable Disease, MERS, SARS, 진단, [키워드] 4C Deterioration model 74 944 participant acute COVID-19 Against benefit Biomarker C-statistic calibration calibration slope calibration-in-the-large candidate clinical Clinical deterioration clinical deterioration outcome Clinical management clinical utility Cohort coronavirus COVID-19 Critical care death Decision making defined Department development discrimination eight England European evaluate Final finding for inclusion foundation funding generalisability greater health protection hospital Hospital admission hospitalised Imperial College London In-hospital internal–external cross-validation ISARIC 4C ISARIC4C London Medical Research Council Melinda Gate Melinda Gates multivariable logistic regression multivariable logistic regression model National Health Service NHS NIHR NIHR HPRU outcome Participants predict predictor Prognosis prognostic prognostic model prospective cohort study protection recruited Region regions required respiratory respiratory infections risk the selected model unit University of Liverpool ventilatory support Wellcome Trust with COVID-19 zoonotic infections [DOI] 10.1016/S2213-2600(20)30559-2 PMC 바로가기 [Article Type] Multicenter Study
Testing olfactory dysfunction in acute and recovered COVID-19 patients: a single center study in ItalyCovid-19 Published on 2021-03-262022-10-30 Journal: Neurological Sciences [Category] COVID-19, MERS, SARS, [키워드] acute COVID-19 acute illness acutely ill patient Anosmia antibody appear association Clinical characteristics cohorts of patient coronavirus disease COVID-19 demographic dysfunction Frequency hospitalized patient Hyposmia investigated Italian population Italy median Molecular diagnosis molecular test nasal olfactory olfactory dysfunction olfactory test Olfactory testing participant Patient positive recovered reported Result SARS-CoV-2 scored significantly higher single center subject subjects supplementary material Symptom Symptoms symptoms onset Testing was performed [DOI] 10.1007/s10072-021-05200-7 PMC 바로가기 [Article Type] Covid-19
Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortalityResearch Published on 2021-03-222022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 30-Day mortality 95% CI acute COVID-19 acute respiratory distress adjusted age ARDS AUC Biomarker calculated changes in clinician Comorbidity Concentration control group COVID-19 COVID-19 convalescent patients COVID-19 disease severity COVID-19 patient COVID-19 patients COVID-19 severity COVID-19 symptoms critically ill patients cut-off determine dialysis disease disease severity elevated ELISA Gender Germany healthy control healthy volunteer High-flow nasal oxygen IMPROVE Increases information Inpatient intensive care unit male management mechanical ventilation Mortality need for oxygen Non-COVID-19 Observational cohort study Odds ratio Organ failure organ support Patient Pneumonia predict prediction primary endpoint qSOFA RAGE receptor Respiratory failure Result risk secondary endpoint serum severe disease severity shown SOFA Soluble RAGE subsequent supplementary material Support syndrome therapy Variation was measured were measured with COVID-19 [DOI] 10.1186/s13613-021-00836-2 PMC 바로가기 [Article Type] Research
Direct and indirect evidence of efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: a rapid systematic reviewCovid-19에서 운동성 불포화도에 대한 급속 운동 검사의 효능과 안전성에 대한 직간접적 증거: 신속한 체계적인 검토Research Published on 2021-03-162022-09-01 Journal: Systematic Reviews [Category] SARS, 진단, [키워드] 1-min sit-to-stand test 40-step test 6-min walk test Accuracy acute COVID-19 AMED applicability calculate CINAHL Clinical practice conditions correlation COVID-19 COVID-19 patients database Desaturation described diagnostic Diagnostic accuracy Direct Efficacy and safety eligible evaluated Evidence exertion Formal Google Guidance heterogeneity Hidden hypoxia hypoxia intensity Interstitial lung disease less lung Lung disease Lung diseases Meta-analysis Methodological quality Negative predictive value Normoxia, Silent hypoxia participant Patient patients Pneumonia positive precluded Predictive Predictive value protocol pulmonary disease pulse oximetry raise Rapid test Rapid tests raw data reference standard Research question Result Scholar searched sensitivity specificity Study design supplementary material systematic review the patient validation study [DOI] 10.1186/s13643-021-01620-w PMC 바로가기 [Article Type] Research
Determining the level of social distancing necessary to avoid future COVID-19 epidemic waves: a modelling study for North East LondonArticle Published on 2021-03-112022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] acute COVID-19 Applied mathematics average calibrated Care Combination Contact COVID-19 COVID-19 case COVID-19 cases COVID-19 epidemic deaths described Determining East effective eight Epidemic epidemic wave Epidemiology Health healthcare hospital discharge hospitalised patient In-hospital death increase in Increasing induce infections Intervention Keeping limit lockdown lockdowns London maintain Mathematical modelling measure Measures nine North Occurrence predict Prevent proportion PROTECT quantified reduction Reproduction number required risk second wave SEIR significantly increased social contact social distancing social distancing measures social interaction suppress symptomatic infection the epidemic transmission of SARS-CoV-2 viral infection was used [DOI] 10.1038/s41598-021-84907-1 PMC 바로가기 [Article Type] Article