Tacrolimus exposure windows responsible for Listeria monocytogenes infection susceptibilityArticle Published on 2021-06-022024-09-04 Journal: Transplant infectious disease : an official journa [Category] 대상포진, [키워드] Adaptive immunity Immune suppression Intracelluar bacteria opportunistic infection T cell [DOI] 10.1111/tid.13655 PMC 바로가기 [Article Type] Article
Lung-resident memory B cells protect against bacterial pneumonia폐 거주 기억 B 세포는 세균성 폐렴으로부터 보호합니다.Research Article Published on 2021-06-012023-08-30 Journal: The Journal of Clinical Investigation [Category] E형 간염, 폐렴구균 감염증, [키워드] Adaptive immunity Bacterial infections immunology Pulmonology [DOI] 10.1172/JCI141810 PMC 바로가기 [Article Type] Research Article
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A 2 G2DResearch Article Published on 2021-06-012023-06-15 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] Adaptive immunity antigen-presenting cells T cells Virology [DOI] 10.1172/JCI147201 PMC 바로가기 [Article Type] Research Article
Histone deficiency and accelerated replication stress in T cell agingResearch Article Published on 2021-06-012023-06-16 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] Adaptive immunity aging cell cycle cellular senescence [DOI] 10.1172/JCI143632 PMC 바로가기 [Article Type] Research Article
Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirusResearch Article Published on 2021-05-242022-10-30 Journal: JCI Insight [Category] COVID-19, [키워드] acute respiratory syndrome Adaptive immunity binding Cellular immune response Clinical symptoms controls coronavirus Coronaviruses disease DNA vaccine dose effective exhibited full-length human-to-human transmission immunized Infectious disease Intradermal intramuscular lung macaque MERS-CoV MERS-CoV infection Middle East morbidity and mortality neutralizing antibody PROTECT Protein reduced regimen reservoirs respiratory syndrome coronavirus rhesus macaque rhesus macaques SARS-CoV SARS-CoV-2 severity Support Transmission vaccination Vaccine Vaccines zoonotic [DOI] 10.1172/jci.insight.146082 PMC 바로가기 [Article Type] Research Article
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike proteinArticle Published on 2021-05-212023-06-18 Journal: Nature Medicine [Category] Fulltext, SARS, [키워드] Adaptive immunity antibodies coronavirus COVID-19 Human monoclonal SARS-CoV SARS-CoV-2 [DOI] 10.1038/s41591-020-0998-x PMC 바로가기 [Article Type] Article
Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvantsArticle Published on 2021-05-212024-09-02 Journal: NPJ Vaccines [Category] 대상포진, [키워드] Adaptive immunity immunology Medical research Translational research Vaccines [DOI] 10.1038/s41541-021-00337-0 PMC 바로가기 [Article Type] Article
Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seqLIBRA-seq를 통한 회복기 COVID-19 환자의 SARS-CoV-2 특이적 기억 B 세포의 신속한 분리 및 면역 프로파일링Article Published on 2021-05-172022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, [키워드] activated Adaptive immunity analyzed antibody Antigen B cell response BCR binding affinity CD11c Cell convalescent COVID-19 patient convalescent COVID-19 patients convalescent individuals Critical Diversity domain ELISA assay exhibited FIVE Frequency heterogeneity immune profiling immune responses Immunoglobulin in vitro Infectious diseases Isolation memory memory B memory B cell memory B cells Neutralizing activity nucleoprotein performed plasma B cell plasma B cells proportion provide pseudotyped Rapid RBD SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 virus Sequencing single-cell level Single-cell RNA sequencing specificity Spectrum transcriptional VDJ Via [DOI] 10.1038/s41392-021-00610-7 PMC 바로가기 [Article Type] Article
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice자가 증폭 RNA 및 아데노바이러스 COVID 백신을 사용한 이종 백신 요법은 생쥐에서 강력한 면역 반응을 유도합니다Article Published on 2021-05-172022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] Adaptive immunity Antibody Response Antibody responses boost CD4 T cells Cellular immune response ChAdOx1 clinical trial clinical trials comparable COVID COVID-19 Cytotoxic T cell Cytotoxic T cells demonstrated disease Efficacy example Heterologous heterologous prime-boost heterologous vaccination regimen heterologous vaccination regimens homologous immune response immunogenicity induce Infectious diseases mice Neutralising titre regimen regimens RNA RNA vaccine robust SARS-CoV-2 Single-dose T cells Th1 titre titres vaccination Vaccine Vaccines vectored vaccine viral vectors [DOI] 10.1038/s41467-021-23173-1 PMC 바로가기 [Article Type] Article
Immunological Aspects of SARS-CoV-2 Infection and the Putative Beneficial Role of Vitamin-DReview Published on 2021-05-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression activating Activation acute respiratory syndrome adaptive Adaptive immunity Alveolar Type II amplification angiotensin-converting enzyme 2 antibody Antigen antimicrobial peptide aspect attenuate autophagy B cells Bioavailability caused CD4 Cell cells circulating combating complex Concentration coronavirus Coronavirus disease 2019 Coronavirus-2 correlated COVID-19 criteria cytokine release Cytokine storm Cytokine storms defend Degradation determine dosage Effectiveness ENhance enzyme epithelial cell Evidence expression Future Health immune response Immunity incidence increase individuals with COVID-19 infect Inflammation inhibit inhibiting Innate immunity Interaction Local lysosomal macrophages mechanism meet Multiple nuclear observation Organ failure Particle Population pro-inflammatory cytokine progression promote RAS receptors renin–angiotensin–aldosterone system required responsible role SARS-CoV-2 SARS-CoV-2 viral particles secretion serum severe acute respiratory syndrome coronavirus 2 severity of COVID-19 shown Signaling Spike protein suppresse T cell T cells T helper tissue Toll-like receptor virus Vitamin D Vitamin D supplementation [DOI] 10.3390/ijms22105251 PMC 바로가기 [Article Type] Review