Antiviral effect – Page 22 – Communicable Diseases Research

In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2

Article

Published on 2020-10-312022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Antiviral and Immunomodulatory Effects of Phytochemicals from Honey against COVID-19: Potential Mechanisms of Action and Future Directions

Review

Published on 2020-10-292022-10-30
Journal: Molecules [Category] COVID-19, MERS, SARS,

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

530

Published on 2020-10-272022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome animal model Antiviral antiviral activity antiviral drug Antiviral effect antiviral efficacy antiviral therapy Antiviral treatment baseline candidate Candidates clinical clinical trial Consensus Contact coronavirus COVID-19 COVID-19 patient COVID-19 patients dose drug effective Efficacy evaluate Evidence exhibit Favipiravir ferrets globe hamster hamsters High dose Human Hydroxychloroquine identify in vivo Infection infectious virus titer lack low dose lung Lung histopathology macaque Mild nontoxic preclinical model Prophylactic Prophylaxis protective effect reduced reduction in Repurposed drug required SARS-CoV-2 Significance significantly small molecule Spread suggested therapeutic toxic effects Transmission Treatment use of hydroxychloroquine viral disease virus virus levels virus transmission Wuhan
[DOI] 10.1073/pnas.2014441117 PMC 바로가기 [Article Type] 530

A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics

실용적인 무작위 통제 시험에서 코로나바이러스 질병 2019 바이러스 동력학에 대한 하이드록시클로로퀸의 효능 부족 보고

Article

Published on 2020-10-202022-08-13
Journal: Nature Communications [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission age Antiviral effect antiviral effects coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dose drug Efficacy eligible FIVE greater Human Hydroxychloroquine hydroxychloroquine therapy Identifier infected with SARS-CoV-2 lack moderately severe COVID-19 Older Oropharyngeal patients hospitalized positive patient Pragmatic Randomized Randomized controlled trial Randomized controlled trials respiratory SARS-CoV-2 SARS-CoV-2 oropharyngeal viral load Seven significantly standard care study inclusion Therapeutics therapy Treatment treatment of COVID-19 use of hydroxychloroquine Viral viral infection viral kinetics Viral load
[DOI] 10.1038/s41467-020-19056-6 PMC 바로가기 [Article Type] Article

Reduction of Coronavirus Burden With Mass Azithromycin Distribution

대량 아지스로마이신 분포로 코로나바이러스 부담 감소

Brief Reports

Published on 2020-10-152022-08-13
Journal: Clinical Infectious Diseases: An Official Publicat [Category] 임상,

[키워드] acute respiratory syndrome Antiviral effect Azithromycin burden children clinical coronavirus distributions Drug administration evaluated mass nasopharyngeal Niger Registration respiratory virome
[DOI] 10.1093/cid/ciaa606 PMC 바로가기 [Article Type] Brief Reports

Development of an antibody-dependent cellular cytotoxicity reporter assay for measuring anti-Middle East Respiratory Syndrome antibody bioactivity

Article

Published on 2020-10-062022-10-29
Journal: Scientific Reports [Category] Coronavirus, MERS,

[키워드] ADCC ADCC activity addition antibodies antibody antibody-dependent cellular cytotoxicity antiviral antibody Antiviral effect Bioactivity Biological techniques cause Cell condition coronavirus demonstrated development Drug discovery East effector cells expressing high accuracy in vivo include infections Live virus MERS MERS-CoV MERS-S Middle East Modification N-glycosylation neutralization activity Neutralization assay NFAT pathogen Precision provide pseudovirus recent reporter reporter gene assay required respiratory robust target cell the spike protein therapeutic Treatment virulent virus clearance
[DOI] 10.1038/s41598-020-73960-x PMC 바로가기 [Article Type] Article

Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro

시험관 내 산화질소에 의한 SARS-CoV-2 복제 완화

Article

Published on 2020-10-012022-09-11
Journal: Redox Biology [Category] SARS, 치료제,

[키워드] 3CL 3CL Protease active site acute respiratory syndrome Antiviral effect Care cells correlated CoV replication COVID-19 cysteine dose effective effort enzyme evaluated expected FRET global public health global public health emergency Health Health care health care systems hypoxia in vitro inhibit SARS-CoV-2 inhibitory effect Mitigation nitric oxide Patient prevented Prophylaxis protease protective effect reducing reduction in released Replication replication of SARS-CoV-2 respiratory S-nitroso-N-acetylpenicillamine SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 protease SARS-CoV-2 replication Severe acute respiratory syndrome SNAP tested treated Treatment Vaccine Viral viral cytopathic effect viral replication
[DOI] 10.1016/j.redox.2020.101734 PMC 바로가기 [Article Type] Article

SARS-CoV-2 clearance in COVID-19 patients with Novaferon treatment: A randomized, open-label, parallel-group trial

Research article

Published on 2020-10-012022-10-05
Journal: International Journal of Infectious Diseases [Category] SARS, 신약개발, 임상, 치료법, 치료제,

[키워드] Aerosolized inhalation anti-SARS-CoV-2 Antiviral antiviral drug Antiviral effect Cell Chinese clearance rate clinical COVID-19 COVID-19 patient COVID-19 patients EC50 Effect enrolled evaluated exhibited group healthy in vitro infected with SARS-CoV-2 inhibited Laboratory Lopinavir/ritonavir median time nine Novaferon number Open-label parallel-group prevented primary endpoint Protein Randomized reduction in registry Result SARS-CoV-2 SARS-CoV-2 clearance SARS-CoV-2 entry secondary endpoint significantly higher the SARS-CoV-2 three groups Treatment Trial viral clearance viral clearance rate viral infection viral replication was determined
[DOI] 10.1016/j.ijid.2020.07.053 [Article Type] Research article

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

Research Article

Published on 2020-09-282022-10-30
Journal: National Science Review [Category] COVID-19,

[키워드] 95% CI absolute difference adverse event adverse events Antiviral effect Chloroquine Chloroquine phosphate combating controls coronavirus COVID-19 COVID-19 pandemic Critical case different dose dose duration of fever Efficacy Efficacy and safety enrolled Evidence geometric mean ratio Guangdong hospital Hospitalization in vitro include median median time multicenter outcome pandemic Patient patients older preliminary evidence primary endpoint proportion prospective observational study provide randomized trial SARS-CoV-2 SARS-COV-2 infection secondary Serious Adverse Event the SARS-CoV-2 therapy treated Treatment undetectable Viral RNA
[DOI] 10.1093/nsr/nwaa113 PMC 바로가기 [Article Type] Research Article

Flavonoids: A complementary approach to conventional therapy of COVID-19?

Article

Published on 2020-09-182022-10-29
Journal: Phytochemistry Reviews [Category] COVID-19,